SUFENTANIL AND NITROUS OXIDE ANAESTHESIA FOR CARDIAC SURGERY
We have investigated the use of sufentanil 3.75–15 μg kg-1 by supplementing anaesthesia with nitrous oxide and midazolam. Thirty patients with ejection fractions exceeding 30% were studied while undergoing scheduled coronary artery vein graft surgery. Even in the lowest dose group (3.75 μg kg-1), ha...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1988-12, Vol.61 (6), p.662-668 |
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| container_end_page | 668 |
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| container_issue | 6 |
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| container_title | British journal of anaesthesia : BJA |
| container_volume | 61 |
| creator | WINDSOR, J.P.W. SHERRY, K. FENECK, R.O. SEBEL, P.S. |
| description | We have investigated the use of sufentanil 3.75–15 μg kg-1 by supplementing anaesthesia with nitrous oxide and midazolam. Thirty patients with ejection fractions exceeding 30% were studied while undergoing scheduled coronary artery vein graft surgery. Even in the lowest dose group (3.75 μg kg-1), haemodynamic responses to surgical and anaesthetic stimuli were sufficiently obtunded that no patient exhibited an increase in heart rate or systolic arterial pressure greater than 20% of the control value. Marked hypotension occurred in some patients during unstimulated periods. Such periods of hypotension were associated with equally marked decreases in systemic vascular resistance. The mean recovery times to spontaneous ventilation after the end of surgery ranged from 6 to 12 h. This is longer than would be expected from other studies using a similar dose of sufentanil. This may be related to the use of benzodiazepines during anaesthesia and to their use after surgery in those patients who became restless. |
| doi_str_mv | 10.1093/bja/61.6.662 |
| format | Article |
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Thirty patients with ejection fractions exceeding 30% were studied while undergoing scheduled coronary artery vein graft surgery. Even in the lowest dose group (3.75 μg kg-1), haemodynamic responses to surgical and anaesthetic stimuli were sufficiently obtunded that no patient exhibited an increase in heart rate or systolic arterial pressure greater than 20% of the control value. Marked hypotension occurred in some patients during unstimulated periods. Such periods of hypotension were associated with equally marked decreases in systemic vascular resistance. The mean recovery times to spontaneous ventilation after the end of surgery ranged from 6 to 12 h. This is longer than would be expected from other studies using a similar dose of sufentanil. This may be related to the use of benzodiazepines during anaesthesia and to their use after surgery in those patients who became restless.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/61.6.662</identifier><identifier>PMID: 2974713</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia Recovery Period ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics - administration & dosage ; Biological and medical sciences ; Coronary Vessels - surgery ; Fentanyl - administration & dosage ; Fentanyl - analogs & derivatives ; Hemodynamics ; Humans ; Medical sciences ; Nitrous Oxide ; Sufentanil ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><ispartof>British journal of anaesthesia : BJA, 1988-12, Vol.61 (6), p.662-668</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-423b83c1db016c666bf5708ec65978c81713b32c88358189fd14b79a7200cb4e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7015806$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2974713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WINDSOR, J.P.W.</creatorcontrib><creatorcontrib>SHERRY, K.</creatorcontrib><creatorcontrib>FENECK, R.O.</creatorcontrib><creatorcontrib>SEBEL, P.S.</creatorcontrib><title>SUFENTANIL AND NITROUS OXIDE ANAESTHESIA FOR CARDIAC SURGERY</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>We have investigated the use of sufentanil 3.75–15 μg kg-1 by supplementing anaesthesia with nitrous oxide and midazolam. Thirty patients with ejection fractions exceeding 30% were studied while undergoing scheduled coronary artery vein graft surgery. Even in the lowest dose group (3.75 μg kg-1), haemodynamic responses to surgical and anaesthetic stimuli were sufficiently obtunded that no patient exhibited an increase in heart rate or systolic arterial pressure greater than 20% of the control value. Marked hypotension occurred in some patients during unstimulated periods. Such periods of hypotension were associated with equally marked decreases in systemic vascular resistance. The mean recovery times to spontaneous ventilation after the end of surgery ranged from 6 to 12 h. This is longer than would be expected from other studies using a similar dose of sufentanil. This may be related to the use of benzodiazepines during anaesthesia and to their use after surgery in those patients who became restless.</description><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia Recovery Period</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Coronary Vessels - surgery</subject><subject>Fentanyl - administration & dosage</subject><subject>Fentanyl - analogs & derivatives</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nitrous Oxide</subject><subject>Sufentanil</subject><subject>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9LwzAUx4MoOqc3r0IP4snOvKZNUvBSts5VxiZtB-olpGkK1f0y2UT_eyMbOwkPHrzvhy-PD0JXgHuAY3Jfvct7Cj3aozQ4Qh0IGfiUMThGHYwx83EMwRk6t_YdY2BBHJ2i0yBmDiMd9FDMhumkTCbZ2EsmA2-Slfl0VnjTl2yQukuSFuUoLbLEG05zr5_kgyzpe8Usf0zz1wt00si51Zf73UWurOyP_PH0MesnY1-FhG_8MCAVJwrqCgNVlNKqiRjmWtEoZlxxcJ9UJFCck4gDj5saworFkgUYqyrUpItud71rs_rcarsRi9YqPZ_LpV5trWA8ikPipovudqAyK2uNbsTatAtpfgRg8SdLOFmCgqDCyXL49b53Wy10fYD3dlx-s8-lVXLeGLlUrT1gDEPEMXWYv8Nau9Hfh1iaD0EZYZEYvbwJzOkQnsdPonQ83fHaOftqtRFWtXqpdN0arTaiXrX___sLOECLug</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>WINDSOR, J.P.W.</creator><creator>SHERRY, K.</creator><creator>FENECK, R.O.</creator><creator>SEBEL, P.S.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>SUFENTANIL AND NITROUS OXIDE ANAESTHESIA FOR CARDIAC SURGERY</title><author>WINDSOR, J.P.W. ; SHERRY, K. ; FENECK, R.O. ; SEBEL, P.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-423b83c1db016c666bf5708ec65978c81713b32c88358189fd14b79a7200cb4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia Recovery Period</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Coronary Vessels - surgery</topic><topic>Fentanyl - administration & dosage</topic><topic>Fentanyl - analogs & derivatives</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nitrous Oxide</topic><topic>Sufentanil</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WINDSOR, J.P.W.</creatorcontrib><creatorcontrib>SHERRY, K.</creatorcontrib><creatorcontrib>FENECK, R.O.</creatorcontrib><creatorcontrib>SEBEL, P.S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WINDSOR, J.P.W.</au><au>SHERRY, K.</au><au>FENECK, R.O.</au><au>SEBEL, P.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SUFENTANIL AND NITROUS OXIDE ANAESTHESIA FOR CARDIAC SURGERY</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>61</volume><issue>6</issue><spage>662</spage><epage>668</epage><pages>662-668</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have investigated the use of sufentanil 3.75–15 μg kg-1 by supplementing anaesthesia with nitrous oxide and midazolam. Thirty patients with ejection fractions exceeding 30% were studied while undergoing scheduled coronary artery vein graft surgery. Even in the lowest dose group (3.75 μg kg-1), haemodynamic responses to surgical and anaesthetic stimuli were sufficiently obtunded that no patient exhibited an increase in heart rate or systolic arterial pressure greater than 20% of the control value. Marked hypotension occurred in some patients during unstimulated periods. Such periods of hypotension were associated with equally marked decreases in systemic vascular resistance. The mean recovery times to spontaneous ventilation after the end of surgery ranged from 6 to 12 h. This is longer than would be expected from other studies using a similar dose of sufentanil. This may be related to the use of benzodiazepines during anaesthesia and to their use after surgery in those patients who became restless.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2974713</pmid><doi>10.1093/bja/61.6.662</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1988-12, Vol.61 (6), p.662-668 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Anesthesia Anesthesia depending on type of surgery Anesthesia Recovery Period Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics - administration & dosage Biological and medical sciences Coronary Vessels - surgery Fentanyl - administration & dosage Fentanyl - analogs & derivatives Hemodynamics Humans Medical sciences Nitrous Oxide Sufentanil Thoracic and cardiovascular surgery. Cardiopulmonary bypass |
| title | SUFENTANIL AND NITROUS OXIDE ANAESTHESIA FOR CARDIAC SURGERY |
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