Heterogenous effects of bryostatin on human myeloid leukemia clonogenicity: Dose and time scheduling dependency

The potent anti-neoplastic actions displayed in vitro by bryostatins have led to the introduction of short-term bryostatin-1 infusions in phase I clinical trials. Because bryostatin (bryo) undergoes a rapid clearance in vivo, we were interested in its scheduling effects on acute myeloid leukemia (AM...

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Veröffentlicht in:	Leukemia research 1996-09, Vol.20 (9), p.743-750
Hauptverfasser:	Van der Hem, Klaas G., Schuurhuis, Gerrit Jan, Dräger, Angelika M., Odding, Joan H., Huijgens, Peter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease acute myeloid leukemia Adult Aged Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Bryostatin Bryostatins Cells, Cultured - drug effects colony forming assay Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Lactones - administration & dosage Lactones - pharmacology Leukemia, Myeloid - blood Leukemia, Myeloid - pathology Macrolides Male Middle Aged Reproducibility of Results Tumor Stem Cell Assay
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