On the feasibility of real-time, in vivo harmonic imaging with proteinaceous microspheres
Harmonic imaging is a new contrast‐specific imaging modality, which utilizes the nonlinear properties of microbubble‐based sonographic contrast agents by transmitting at the fundamental frequency but receiving at the second harmonic frequency. The feasibility of improving the detection of slow, smal...
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| Veröffentlicht in: | Journal of ultrasound in medicine 1996-12, Vol.15 (12), p.853-860 |
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| container_issue | 12 |
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| container_title | Journal of ultrasound in medicine |
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| creator | Forsberg, F Goldberg, B. B Liu, J. B Merton, D. A Rawool, N. M |
| description | Harmonic imaging is a new contrast‐specific imaging modality, which utilizes the nonlinear properties of microbubble‐based sonographic contrast agents by transmitting at the fundamental frequency but receiving at the second harmonic frequency. The feasibility of improving the detection of slow, small‐volume blood flow using real‐time harmonic imaging has been investigated in vivo. Proteinaceous microspheres (FS069) were administrated to four dogs, two woodchucks (with multiple hepatomas), and one rabbit. Three different scanners were used to obtain real‐time images of kidneys and liver (including vessels) in harmonic and conventional gray scale and color flow modes. The duration of contrast enhancement lasted significantly longer in harmonic than in conventional modes (on average 87 s; P = 0.008). Harmonic images were less susceptible to artifacts, such as acoustic shadowing, and a clear increase in the (flow) signal‐to‐noise ratio was observed. These preliminary in vivo results demonstrate the feasibility of performing real‐time, contrast‐enhanced harmonic imaging, but further studies are required to establish clinical efficacy. |
| doi_str_mv | 10.7863/jum.1996.15.12.853 |
| format | Article |
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B ; Liu, J. B ; Merton, D. A ; Rawool, N. M</creator><creatorcontrib>Forsberg, F ; Goldberg, B. B ; Liu, J. B ; Merton, D. A ; Rawool, N. M</creatorcontrib><description>Harmonic imaging is a new contrast‐specific imaging modality, which utilizes the nonlinear properties of microbubble‐based sonographic contrast agents by transmitting at the fundamental frequency but receiving at the second harmonic frequency. The feasibility of improving the detection of slow, small‐volume blood flow using real‐time harmonic imaging has been investigated in vivo. Proteinaceous microspheres (FS069) were administrated to four dogs, two woodchucks (with multiple hepatomas), and one rabbit. Three different scanners were used to obtain real‐time images of kidneys and liver (including vessels) in harmonic and conventional gray scale and color flow modes. The duration of contrast enhancement lasted significantly longer in harmonic than in conventional modes (on average 87 s; P = 0.008). Harmonic images were less susceptible to artifacts, such as acoustic shadowing, and a clear increase in the (flow) signal‐to‐noise ratio was observed. These preliminary in vivo results demonstrate the feasibility of performing real‐time, contrast‐enhanced harmonic imaging, but further studies are required to establish clinical efficacy.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.7863/jum.1996.15.12.853</identifier><identifier>PMID: 8947861</identifier><identifier>CODEN: JUMEDA</identifier><language>eng</language><publisher>Laurel, MD: Am inst Ulrrasound Med</publisher><subject>Animals ; Biological and medical sciences ; Carcinoma, Hepatocellular - diagnostic imaging ; Contrast Media ; Dogs ; Feasibility Studies ; Image Enhancement - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney - diagnostic imaging ; Liver - diagnostic imaging ; Liver Neoplasms - diagnostic imaging ; Marmota ; Medical sciences ; Microspheres ; Miscellaneous. 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B</creatorcontrib><creatorcontrib>Liu, J. B</creatorcontrib><creatorcontrib>Merton, D. A</creatorcontrib><creatorcontrib>Rawool, N. M</creatorcontrib><title>On the feasibility of real-time, in vivo harmonic imaging with proteinaceous microspheres</title><title>Journal of ultrasound in medicine</title><addtitle>J Ultrasound Med</addtitle><description>Harmonic imaging is a new contrast‐specific imaging modality, which utilizes the nonlinear properties of microbubble‐based sonographic contrast agents by transmitting at the fundamental frequency but receiving at the second harmonic frequency. The feasibility of improving the detection of slow, small‐volume blood flow using real‐time harmonic imaging has been investigated in vivo. Proteinaceous microspheres (FS069) were administrated to four dogs, two woodchucks (with multiple hepatomas), and one rabbit. Three different scanners were used to obtain real‐time images of kidneys and liver (including vessels) in harmonic and conventional gray scale and color flow modes. The duration of contrast enhancement lasted significantly longer in harmonic than in conventional modes (on average 87 s; P = 0.008). Harmonic images were less susceptible to artifacts, such as acoustic shadowing, and a clear increase in the (flow) signal‐to‐noise ratio was observed. These preliminary in vivo results demonstrate the feasibility of performing real‐time, contrast‐enhanced harmonic imaging, but further studies are required to establish clinical efficacy.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Contrast Media</subject><subject>Dogs</subject><subject>Feasibility Studies</subject><subject>Image Enhancement - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney - diagnostic imaging</subject><subject>Liver - diagnostic imaging</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Marmota</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Miscellaneous. Technology</subject><subject>Rabbits</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv1DAUhS0EKkPhDyAheYFYkWA7fsQbpKriqaJu6IKVZSfXE1d5DHam0fx7HCYqW1aW7j33-DsHodeUlKqW1Yf741BSrWVJRUlZWYvqCdpRIUihJa2eoh1hqi440-o5epHSPSGMUMUv0EWteXagO_TrdsRzB9iDTcGFPswnPHkcwfbFHAZ4j8OIH8LDhDsbh2kMDQ6D3Ydxj5cwd_gQpxnCaBuYjgkPoYlTOnQQIb1Ez7ztE7za3kt09_nTz-uvxc3tl2_XVzdFw4WqCpkDaAvOVVKztgbetkrW1HnltFIKKi08A9F6T2TNeeW0k8LL1ovGEsdddYnenX0zyu8jpNkMITXQ93ZcmYyqhWaM8SxkZ-HKmCJ4c4g5SzwZSszap8l9mrVPQ4WhzOQ-89Gbzf3oBmgfT7YC8_7ttrepsb2PdmxCepQxQaX6K_t4li2hh9N_fGy-3_1YJ1RQdubYUnZh3y0hgkmD7ftMRc2yLP-A_wA03p9V</recordid><startdate>199612</startdate><enddate>199612</enddate><creator>Forsberg, F</creator><creator>Goldberg, B. B</creator><creator>Liu, J. B</creator><creator>Merton, D. A</creator><creator>Rawool, N. M</creator><general>Am inst Ulrrasound Med</general><general>American Institute of Ultrasound in Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199612</creationdate><title>On the feasibility of real-time, in vivo harmonic imaging with proteinaceous microspheres</title><author>Forsberg, F ; Goldberg, B. B ; Liu, J. B ; Merton, D. A ; Rawool, N. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4573-61999aebb3692d8e4dd7681bf7b9777e395f2e5dff068443b9b65f6df5ca0b4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Contrast Media</topic><topic>Dogs</topic><topic>Feasibility Studies</topic><topic>Image Enhancement - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidney - diagnostic imaging</topic><topic>Liver - diagnostic imaging</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Marmota</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>Miscellaneous. Technology</topic><topic>Rabbits</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forsberg, F</creatorcontrib><creatorcontrib>Goldberg, B. B</creatorcontrib><creatorcontrib>Liu, J. B</creatorcontrib><creatorcontrib>Merton, D. A</creatorcontrib><creatorcontrib>Rawool, N. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forsberg, F</au><au>Goldberg, B. B</au><au>Liu, J. B</au><au>Merton, D. A</au><au>Rawool, N. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the feasibility of real-time, in vivo harmonic imaging with proteinaceous microspheres</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>1996-12</date><risdate>1996</risdate><volume>15</volume><issue>12</issue><spage>853</spage><epage>860</epage><pages>853-860</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><coden>JUMEDA</coden><abstract>Harmonic imaging is a new contrast‐specific imaging modality, which utilizes the nonlinear properties of microbubble‐based sonographic contrast agents by transmitting at the fundamental frequency but receiving at the second harmonic frequency. The feasibility of improving the detection of slow, small‐volume blood flow using real‐time harmonic imaging has been investigated in vivo. Proteinaceous microspheres (FS069) were administrated to four dogs, two woodchucks (with multiple hepatomas), and one rabbit. Three different scanners were used to obtain real‐time images of kidneys and liver (including vessels) in harmonic and conventional gray scale and color flow modes. The duration of contrast enhancement lasted significantly longer in harmonic than in conventional modes (on average 87 s; P = 0.008). Harmonic images were less susceptible to artifacts, such as acoustic shadowing, and a clear increase in the (flow) signal‐to‐noise ratio was observed. These preliminary in vivo results demonstrate the feasibility of performing real‐time, contrast‐enhanced harmonic imaging, but further studies are required to establish clinical efficacy.</abstract><cop>Laurel, MD</cop><pub>Am inst Ulrrasound Med</pub><pmid>8947861</pmid><doi>10.7863/jum.1996.15.12.853</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of ultrasound in medicine, 1996-12, Vol.15 (12), p.853-860 |
| issn | 0278-4297 1550-9613 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Carcinoma, Hepatocellular - diagnostic imaging Contrast Media Dogs Feasibility Studies Image Enhancement - methods Investigative techniques, diagnostic techniques (general aspects) Kidney - diagnostic imaging Liver - diagnostic imaging Liver Neoplasms - diagnostic imaging Marmota Medical sciences Microspheres Miscellaneous. Technology Rabbits Ultrasonic investigative techniques Ultrasonography |
| title | On the feasibility of real-time, in vivo harmonic imaging with proteinaceous microspheres |
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