Azithromycin in the treatment of periodontal disease Effect on microbial flora
Azithromycin is an azalide antibiotic with excellent in vitro activity against a wide variety of oral bacteria. It has a long half‐life, good tissue penetration and is preferentially taken up by phagocytes. We investigated the microbiological efficacy of azithromycin as an adjunct to the non‐surgica...
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| Veröffentlicht in: | Journal of clinical periodontology 1996-11, Vol.23 (11), p.998-1003 |
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| container_title | Journal of clinical periodontology |
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| creator | Sefton, A.M. Maskell, J.P. Beighton, D. Whiley, A. Shain, H. Foyle, D. Smith, S.R. Smales, F.C. Williams, J.D. |
| description | Azithromycin is an azalide antibiotic with excellent in vitro activity against a wide variety of oral bacteria. It has a long half‐life, good tissue penetration and is preferentially taken up by phagocytes. We investigated the microbiological efficacy of azithromycin as an adjunct to the non‐surgical treatment of adult chronic periodontitis: its clinical efficacy is dealt with in a separate paper. 46 patients were treated in a double‐blind placebo controlled trial. Microbiological assessment of the same periodontal pocket (initially >6 mm) was made at weeks 0, 2, 3, 6, 10 and 22. Either azithromycin 500 mg 1×daily for 3 days or placebo was given at week 2. Particular attention was paid to the numbers of black pigmented anaerobes and spirochaetes present since these are the most commonly implicated pathogens in periodontal disease. Pigmented anaerobes were significantly reduced at weeks 3 and 6 in patients who received azithromycin compared to placebo and remained lower, although not significantly so. throughout the study. Counts of spirochaetes were significantly reduced throughout the study in patients who received azithromycin compared to placebo. Our microbiological study suggests that azithromycin may be useful as an adjunct in the treatment of periodontal disease. |
| doi_str_mv | 10.1111/j.1600-051X.1996.tb00527.x |
| format | Article |
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It has a long half‐life, good tissue penetration and is preferentially taken up by phagocytes. We investigated the microbiological efficacy of azithromycin as an adjunct to the non‐surgical treatment of adult chronic periodontitis: its clinical efficacy is dealt with in a separate paper. 46 patients were treated in a double‐blind placebo controlled trial. Microbiological assessment of the same periodontal pocket (initially >6 mm) was made at weeks 0, 2, 3, 6, 10 and 22. Either azithromycin 500 mg 1×daily for 3 days or placebo was given at week 2. Particular attention was paid to the numbers of black pigmented anaerobes and spirochaetes present since these are the most commonly implicated pathogens in periodontal disease. Pigmented anaerobes were significantly reduced at weeks 3 and 6 in patients who received azithromycin compared to placebo and remained lower, although not significantly so. throughout the study. Counts of spirochaetes were significantly reduced throughout the study in patients who received azithromycin compared to placebo. 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It has a long half‐life, good tissue penetration and is preferentially taken up by phagocytes. We investigated the microbiological efficacy of azithromycin as an adjunct to the non‐surgical treatment of adult chronic periodontitis: its clinical efficacy is dealt with in a separate paper. 46 patients were treated in a double‐blind placebo controlled trial. Microbiological assessment of the same periodontal pocket (initially >6 mm) was made at weeks 0, 2, 3, 6, 10 and 22. Either azithromycin 500 mg 1×daily for 3 days or placebo was given at week 2. Particular attention was paid to the numbers of black pigmented anaerobes and spirochaetes present since these are the most commonly implicated pathogens in periodontal disease. Pigmented anaerobes were significantly reduced at weeks 3 and 6 in patients who received azithromycin compared to placebo and remained lower, although not significantly so. throughout the study. Counts of spirochaetes were significantly reduced throughout the study in patients who received azithromycin compared to placebo. Our microbiological study suggests that azithromycin may be useful as an adjunct in the treatment of periodontal disease.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>azithromycin</subject><subject>Azithromycin - pharmacology</subject><subject>Azithromycin - therapeutic use</subject><subject>Bacteria, Anaerobic - drug effects</subject><subject>bacterial pathogens</subject><subject>Colony Count, Microbial</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>periodontal disease</subject><subject>Periodontal Pocket - microbiology</subject><subject>Periodontitis - drug therapy</subject><subject>Periodontitis - microbiology</subject><subject>Spirochaetales - drug effects</subject><subject>Statistics, Nonparametric</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1uEzEUhS1EVULhEZBGLNjN1D8z9pgNqkIaWqrAokB3lsdzrTrMT2o7IunT41Gi7GtZ8uK75_jqQ-gjwQVJ53JdEI5xjivyUBApeREbjCsqit0rNDuh12iGGWY5l0K-QW9DWGNMBGPsHJ3XsiKcihlaXT27-OjHfm_ckKUbHyGLHnTsYYjZaLMNeDe24xB1l7UugA6QLawFk-iQ9c74sXGJ2W70-h06s7oL8P74XqBf14v7-bf87sfyZn51l5tSlHVOOZbUtrSUGLigLVjWGMorAKh1xZqKGF3jxhIQpqTYYGCa0zZFNKtZSdgF-nTo3fjxaQshqt4FA12nBxi3QYm6kpjjOg1-PgymNUPwYNXGu177vSJYTTLVWk3G1GRMTTLVUabapfCH4y_bpof2FD3aS_zLgf9zHexf0Kxu5z8XUk7r5YcGFyLsTg3a_1VcMFGpP6ul-v1wu_x-_XWlBPsPraKVDg</recordid><startdate>199611</startdate><enddate>199611</enddate><creator>Sefton, A.M.</creator><creator>Maskell, J.P.</creator><creator>Beighton, D.</creator><creator>Whiley, A.</creator><creator>Shain, H.</creator><creator>Foyle, D.</creator><creator>Smith, S.R.</creator><creator>Smales, F.C.</creator><creator>Williams, J.D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199611</creationdate><title>Azithromycin in the treatment of periodontal disease Effect on microbial flora</title><author>Sefton, A.M. ; Maskell, J.P. ; Beighton, D. ; Whiley, A. ; Shain, H. ; Foyle, D. ; Smith, S.R. ; Smales, F.C. ; Williams, J.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4748-26092fd2490e672def3bc265eee8a53b51ca80bf1e7c420c0e3a62d2fda383413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>azithromycin</topic><topic>Azithromycin - pharmacology</topic><topic>Azithromycin - therapeutic use</topic><topic>Bacteria, Anaerobic - drug effects</topic><topic>bacterial pathogens</topic><topic>Colony Count, Microbial</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>periodontal disease</topic><topic>Periodontal Pocket - microbiology</topic><topic>Periodontitis - drug therapy</topic><topic>Periodontitis - microbiology</topic><topic>Spirochaetales - drug effects</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sefton, A.M.</creatorcontrib><creatorcontrib>Maskell, J.P.</creatorcontrib><creatorcontrib>Beighton, D.</creatorcontrib><creatorcontrib>Whiley, A.</creatorcontrib><creatorcontrib>Shain, H.</creatorcontrib><creatorcontrib>Foyle, D.</creatorcontrib><creatorcontrib>Smith, S.R.</creatorcontrib><creatorcontrib>Smales, F.C.</creatorcontrib><creatorcontrib>Williams, J.D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sefton, A.M.</au><au>Maskell, J.P.</au><au>Beighton, D.</au><au>Whiley, A.</au><au>Shain, H.</au><au>Foyle, D.</au><au>Smith, S.R.</au><au>Smales, F.C.</au><au>Williams, J.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Azithromycin in the treatment of periodontal disease Effect on microbial flora</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>1996-11</date><risdate>1996</risdate><volume>23</volume><issue>11</issue><spage>998</spage><epage>1003</epage><pages>998-1003</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Azithromycin is an azalide antibiotic with excellent in vitro activity against a wide variety of oral bacteria. 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| ispartof | Journal of clinical periodontology, 1996-11, Vol.23 (11), p.998-1003 |
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| subjects | Adult Analysis of Variance Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use azithromycin Azithromycin - pharmacology Azithromycin - therapeutic use Bacteria, Anaerobic - drug effects bacterial pathogens Colony Count, Microbial Dentistry Double-Blind Method Female Humans Male Microbial Sensitivity Tests periodontal disease Periodontal Pocket - microbiology Periodontitis - drug therapy Periodontitis - microbiology Spirochaetales - drug effects Statistics, Nonparametric |
| title | Azithromycin in the treatment of periodontal disease Effect on microbial flora |
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