EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm
The induction of different cell fates along the dorsoventral axis of the Drosophila embryo requires a graded activity of the EGF receptor tyrosine kinase (DER). Here we have identified primary and secondary target genes of DER, which mediate the determination of discrete ventral cell fates. High lev...
Gespeichert in:
| Veröffentlicht in: | Development (Cambridge) 1996-11, Vol.122 (11), p.3355-3362 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3362 |
|---|---|
| container_issue | 11 |
| container_start_page | 3355 |
| container_title | Development (Cambridge) |
| container_volume | 122 |
| creator | Gabay, L Scholz, H Golembo, M Klaes, A Shilo, B Z Klämbt, C |
| description | The induction of different cell fates along the dorsoventral axis of the Drosophila embryo requires a graded activity of the EGF receptor tyrosine kinase (DER). Here we have identified primary and secondary target genes of DER, which mediate the determination of discrete ventral cell fates. High levels of DER activation in the ventralmost cells trigger expression of the transcription factors encoded by ventral nervous system defective (vnd) and pointed P1 (pntPl). Concomitant with the induction of pntP1, high levels of DER activity lead to inactivation of the Yan protein, a transcriptional repressor of Pointed-target genes. These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan. The simultaneous effects of the DER pathway on pntP1 induction and Yan inactivation may contribute to the definition of the border of the ventralmost cell fates. |
| doi_str_mv | 10.1242/dev.122.11.3355 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78586955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78586955</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-ab20808475ebb9db684c8a8a4dab819e92e8f9bdd3ac0bb2d01f590d8c0367e03</originalsourceid><addsrcrecordid>eNqFkT1rHDEQhkVIcM526lQBVen2LGlXt1Jp_A0Gp0gKV0Ifc3cKu9Ja0p1x559uHXcYXLnSoHnmYYYXoZ-UzCnr2JmDbS3YnNJ523L-Bc1o1_eNpEx-RTMiOWmolPQ7Os75PyGkXfT9EToSklPC2Qy9Xt1c4wQWphITzn4V9ODDCvvgNhYynqIPBRz-Q3FJOmSb_FR8DFgHVyFti9_qUsFHHfCUYgEf6j8ua8CXKeY4rf2gMYwmvcTgLd5CqKIBgy3RQRpP0belHjL8OLwn6N_11d-L2-b-4ebu4vy-sR0TpdGGEUFE13MwRjqzEJ0VWujOaSOoBMlALKVxrtWWGMMcoUsuiRN2dzKQ9gT93nvrkk8byEWNPlsYBh0gbrLqBRcLyfmnIOVCslb2FTzbg7bemRMs1ZT8qNOLokTtwlE1nFowRanahVMnfh3UGzOCe-cPadT-fN9f-9X62SdQxschrnwueSeDIU4fhG9AiZ4F</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15892397</pqid></control><display><type>article</type><title>EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>Gabay, L ; Scholz, H ; Golembo, M ; Klaes, A ; Shilo, B Z ; Klämbt, C</creator><creatorcontrib>Gabay, L ; Scholz, H ; Golembo, M ; Klaes, A ; Shilo, B Z ; Klämbt, C</creatorcontrib><description>The induction of different cell fates along the dorsoventral axis of the Drosophila embryo requires a graded activity of the EGF receptor tyrosine kinase (DER). Here we have identified primary and secondary target genes of DER, which mediate the determination of discrete ventral cell fates. High levels of DER activation in the ventralmost cells trigger expression of the transcription factors encoded by ventral nervous system defective (vnd) and pointed P1 (pntPl). Concomitant with the induction of pntP1, high levels of DER activity lead to inactivation of the Yan protein, a transcriptional repressor of Pointed-target genes. These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan. The simultaneous effects of the DER pathway on pntP1 induction and Yan inactivation may contribute to the definition of the border of the ventralmost cell fates.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.122.11.3355</identifier><identifier>PMID: 8951052</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Animals ; DNA-Binding Proteins - physiology ; Drosophila ; Drosophila melanogaster - embryology ; Drosophila Proteins ; Ectoderm - physiology ; ErbB Receptors - physiology ; Eye Proteins - physiology ; Gene Expression Regulation, Developmental ; In Situ Hybridization ; Morphogenesis ; Nerve Tissue Proteins ; Proto-Oncogene Proteins - physiology ; Receptor Protein-Tyrosine Kinases - physiology ; Repressor Proteins ; Signal Transduction ; Transcription Factors - physiology ; Transcription, Genetic</subject><ispartof>Development (Cambridge), 1996-11, Vol.122 (11), p.3355-3362</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-ab20808475ebb9db684c8a8a4dab819e92e8f9bdd3ac0bb2d01f590d8c0367e03</citedby><cites>FETCH-LOGICAL-c428t-ab20808475ebb9db684c8a8a4dab819e92e8f9bdd3ac0bb2d01f590d8c0367e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3665,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8951052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabay, L</creatorcontrib><creatorcontrib>Scholz, H</creatorcontrib><creatorcontrib>Golembo, M</creatorcontrib><creatorcontrib>Klaes, A</creatorcontrib><creatorcontrib>Shilo, B Z</creatorcontrib><creatorcontrib>Klämbt, C</creatorcontrib><title>EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The induction of different cell fates along the dorsoventral axis of the Drosophila embryo requires a graded activity of the EGF receptor tyrosine kinase (DER). Here we have identified primary and secondary target genes of DER, which mediate the determination of discrete ventral cell fates. High levels of DER activation in the ventralmost cells trigger expression of the transcription factors encoded by ventral nervous system defective (vnd) and pointed P1 (pntPl). Concomitant with the induction of pntP1, high levels of DER activity lead to inactivation of the Yan protein, a transcriptional repressor of Pointed-target genes. These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan. The simultaneous effects of the DER pathway on pntP1 induction and Yan inactivation may contribute to the definition of the border of the ventralmost cell fates.</description><subject>Animals</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila Proteins</subject><subject>Ectoderm - physiology</subject><subject>ErbB Receptors - physiology</subject><subject>Eye Proteins - physiology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>In Situ Hybridization</subject><subject>Morphogenesis</subject><subject>Nerve Tissue Proteins</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Receptor Protein-Tyrosine Kinases - physiology</subject><subject>Repressor Proteins</subject><subject>Signal Transduction</subject><subject>Transcription Factors - physiology</subject><subject>Transcription, Genetic</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1rHDEQhkVIcM526lQBVen2LGlXt1Jp_A0Gp0gKV0Ifc3cKu9Ja0p1x559uHXcYXLnSoHnmYYYXoZ-UzCnr2JmDbS3YnNJ523L-Bc1o1_eNpEx-RTMiOWmolPQ7Os75PyGkXfT9EToSklPC2Qy9Xt1c4wQWphITzn4V9ODDCvvgNhYynqIPBRz-Q3FJOmSb_FR8DFgHVyFti9_qUsFHHfCUYgEf6j8ua8CXKeY4rf2gMYwmvcTgLd5CqKIBgy3RQRpP0belHjL8OLwn6N_11d-L2-b-4ebu4vy-sR0TpdGGEUFE13MwRjqzEJ0VWujOaSOoBMlALKVxrtWWGMMcoUsuiRN2dzKQ9gT93nvrkk8byEWNPlsYBh0gbrLqBRcLyfmnIOVCslb2FTzbg7bemRMs1ZT8qNOLokTtwlE1nFowRanahVMnfh3UGzOCe-cPadT-fN9f-9X62SdQxschrnwueSeDIU4fhG9AiZ4F</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Gabay, L</creator><creator>Scholz, H</creator><creator>Golembo, M</creator><creator>Klaes, A</creator><creator>Shilo, B Z</creator><creator>Klämbt, C</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm</title><author>Gabay, L ; Scholz, H ; Golembo, M ; Klaes, A ; Shilo, B Z ; Klämbt, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-ab20808475ebb9db684c8a8a4dab819e92e8f9bdd3ac0bb2d01f590d8c0367e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila Proteins</topic><topic>Ectoderm - physiology</topic><topic>ErbB Receptors - physiology</topic><topic>Eye Proteins - physiology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>In Situ Hybridization</topic><topic>Morphogenesis</topic><topic>Nerve Tissue Proteins</topic><topic>Proto-Oncogene Proteins - physiology</topic><topic>Receptor Protein-Tyrosine Kinases - physiology</topic><topic>Repressor Proteins</topic><topic>Signal Transduction</topic><topic>Transcription Factors - physiology</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabay, L</creatorcontrib><creatorcontrib>Scholz, H</creatorcontrib><creatorcontrib>Golembo, M</creatorcontrib><creatorcontrib>Klaes, A</creatorcontrib><creatorcontrib>Shilo, B Z</creatorcontrib><creatorcontrib>Klämbt, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabay, L</au><au>Scholz, H</au><au>Golembo, M</au><au>Klaes, A</au><au>Shilo, B Z</au><au>Klämbt, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>122</volume><issue>11</issue><spage>3355</spage><epage>3362</epage><pages>3355-3362</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The induction of different cell fates along the dorsoventral axis of the Drosophila embryo requires a graded activity of the EGF receptor tyrosine kinase (DER). Here we have identified primary and secondary target genes of DER, which mediate the determination of discrete ventral cell fates. High levels of DER activation in the ventralmost cells trigger expression of the transcription factors encoded by ventral nervous system defective (vnd) and pointed P1 (pntPl). Concomitant with the induction of pntP1, high levels of DER activity lead to inactivation of the Yan protein, a transcriptional repressor of Pointed-target genes. These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan. The simultaneous effects of the DER pathway on pntP1 induction and Yan inactivation may contribute to the definition of the border of the ventralmost cell fates.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>8951052</pmid><doi>10.1242/dev.122.11.3355</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1996-11, Vol.122 (11), p.3355-3362 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78586955 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals DNA-Binding Proteins - physiology Drosophila Drosophila melanogaster - embryology Drosophila Proteins Ectoderm - physiology ErbB Receptors - physiology Eye Proteins - physiology Gene Expression Regulation, Developmental In Situ Hybridization Morphogenesis Nerve Tissue Proteins Proto-Oncogene Proteins - physiology Receptor Protein-Tyrosine Kinases - physiology Repressor Proteins Signal Transduction Transcription Factors - physiology Transcription, Genetic |
| title | EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T00%3A25%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EGF%20receptor%20signaling%20induces%20pointed%20P1%20transcription%20and%20inactivates%20Yan%20protein%20in%20the%20Drosophila%20embryonic%20ventral%20ectoderm&rft.jtitle=Development%20(Cambridge)&rft.au=Gabay,%20L&rft.date=1996-11-01&rft.volume=122&rft.issue=11&rft.spage=3355&rft.epage=3362&rft.pages=3355-3362&rft.issn=0950-1991&rft.eissn=1477-9129&rft_id=info:doi/10.1242/dev.122.11.3355&rft_dat=%3Cproquest_cross%3E78586955%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15892397&rft_id=info:pmid/8951052&rfr_iscdi=true |