Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice

In nonobese diabetic (NOD) mice, β–cell reactive T–helper type 1 (Th1) responses develop spontaneously and gradually spread, creating a cascade of responses that ultimately destroys the β–cells. The diversity of the autoreactive T–cell repertoire creates a major obstacle to the development of therap...

Ausführliche Beschreibung