PAF and haematopoiesis XII: macrophage colony-stimulating factor (M-CSF) decreases platelet-activating factor (PAF) acetylhydrolase production in macrophagic J774 cells
Platelet-activating factor (PAF) is a phospholipid mediator with major immunoregulatory activities. Macrophages produce PAF acetylhydrolase activity, which regulates blood PAF concentrations. Macrophage colony-stimulating factor (M-CSF) is involved in the differentiation and functions of cells from...
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| Veröffentlicht in: | Cancer letters 1996-10, Vol.107 (2), p.199-204 |
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| container_title | Cancer letters |
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| creator | Dupuis, F. Dulery, C. Praloran, V. Denizot, Y. |
| description | Platelet-activating factor (PAF) is a phospholipid mediator with major immunoregulatory activities. Macrophages produce PAF acetylhydrolase activity, which regulates blood PAF concentrations. Macrophage colony-stimulating factor (M-CSF) is involved in the differentiation and functions of cells from the monocytic/macrophagic lineage. We found that murine macrophagic J774 cells metabolized PAF with lyso PAF as the major metabolite product. As in mouse plasma, the metabolism of PAF by J774 cells was not inhibited by PMSF, p-BPB, DTNB and quinacrine. M-CSF (100–5000 U/ml) significantly decreased PAF acetylhydrolase activity of the J774 cell without exhibiting a significant effect on cell growth. Elevated concentrations of M-CSF are found in blood and tissues during inflammatory states. It could be suggested that a decreased PAF catabolism by tissue macrophages in response to M-CSF may induce local elevated PAF concentrations, thus amplifying the inflammatory response. |
| doi_str_mv | 10.1016/0304-3835(96)04360-1 |
| format | Article |
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Macrophages produce PAF acetylhydrolase activity, which regulates blood PAF concentrations. Macrophage colony-stimulating factor (M-CSF) is involved in the differentiation and functions of cells from the monocytic/macrophagic lineage. We found that murine macrophagic J774 cells metabolized PAF with lyso PAF as the major metabolite product. As in mouse plasma, the metabolism of PAF by J774 cells was not inhibited by PMSF, p-BPB, DTNB and quinacrine. M-CSF (100–5000 U/ml) significantly decreased PAF acetylhydrolase activity of the J774 cell without exhibiting a significant effect on cell growth. Elevated concentrations of M-CSF are found in blood and tissues during inflammatory states. It could be suggested that a decreased PAF catabolism by tissue macrophages in response to M-CSF may induce local elevated PAF concentrations, thus amplifying the inflammatory response.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(96)04360-1</identifier><identifier>PMID: 8947513</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>1-Alkyl-2-acetylglycerophosphocholine Esterase ; Animals ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Haematopoiesis ; Humans ; J774 cells ; Macrophages - drug effects ; Macrophages - enzymology ; Mice ; Mice, Inbred BALB C ; Molecular and cellular biology ; Phospholipases A - antagonists & inhibitors ; Phospholipases A - metabolism ; Platelet Activating Factor - metabolism ; Platelet-activating factor ; Tumor Cells, Cultured</subject><ispartof>Cancer letters, 1996-10, Vol.107 (2), p.199-204</ispartof><rights>1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c250t-5447d6a07a6aec9d68760863db29a12667ca8f7acf12eba58b01adad259b5e903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304383596043601$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2494336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8947513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dupuis, F.</creatorcontrib><creatorcontrib>Dulery, C.</creatorcontrib><creatorcontrib>Praloran, V.</creatorcontrib><creatorcontrib>Denizot, Y.</creatorcontrib><title>PAF and haematopoiesis XII: macrophage colony-stimulating factor (M-CSF) decreases platelet-activating factor (PAF) acetylhydrolase production in macrophagic J774 cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Platelet-activating factor (PAF) is a phospholipid mediator with major immunoregulatory activities. Macrophages produce PAF acetylhydrolase activity, which regulates blood PAF concentrations. Macrophage colony-stimulating factor (M-CSF) is involved in the differentiation and functions of cells from the monocytic/macrophagic lineage. We found that murine macrophagic J774 cells metabolized PAF with lyso PAF as the major metabolite product. As in mouse plasma, the metabolism of PAF by J774 cells was not inhibited by PMSF, p-BPB, DTNB and quinacrine. M-CSF (100–5000 U/ml) significantly decreased PAF acetylhydrolase activity of the J774 cell without exhibiting a significant effect on cell growth. Elevated concentrations of M-CSF are found in blood and tissues during inflammatory states. It could be suggested that a decreased PAF catabolism by tissue macrophages in response to M-CSF may induce local elevated PAF concentrations, thus amplifying the inflammatory response.</description><subject>1-Alkyl-2-acetylglycerophosphocholine Esterase</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Haematopoiesis</subject><subject>Humans</subject><subject>J774 cells</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - enzymology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular and cellular biology</subject><subject>Phospholipases A - antagonists & inhibitors</subject><subject>Phospholipases A - metabolism</subject><subject>Platelet Activating Factor - metabolism</subject><subject>Platelet-activating factor</subject><subject>Tumor Cells, Cultured</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVGL1DAQx4so53r6DRTyIHL7UE2aNknvQTgWV1dOFFTwLUyT6W2kbWrSHuw38mOassuKLz4Nw_z-M3_-k2XPGX3NKBNvKKdlzhWvrmqxpiUXNGcPshVTsshlrejDbHVGHmdPYvxJKa1KWV1kF6pOlfFV9vvLzZbAYMkesIfJj95hdJH82O2uSQ8m-HEPd0iM7_xwyOPk-rmDyQ13pAUz-UCuPuWbr9s1sWgCQsRIxgRgh1OeAHf_L5zOrQkYnA7d_mCD75KCjMHbObF-IG74e9UZ8lHKkhjsuvg0e9RCF_HZqV5m37fvvm0-5Lef3-82N7e5KSo65VVZSiuAShCAprZCSUGV4LYpamCFENKAaiWYlhXYQKUaysCCLaq6qbCm_DJ7ddybTP2aMU66d3FxAAP6OWqpKlUqzhNYHsHkNsaArR6D6yEcNKN6eZBe0tdL-rpOzfIgzZLsxWn_3PRoz6LTR9L85WkO0UDXBhiMi2esKOuSc5Gwt0cMUxb3DoOOxuFg0LqAZtLWu__7-AOjg64W</recordid><startdate>19961022</startdate><enddate>19961022</enddate><creator>Dupuis, F.</creator><creator>Dulery, C.</creator><creator>Praloran, V.</creator><creator>Denizot, Y.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961022</creationdate><title>PAF and haematopoiesis XII: macrophage colony-stimulating factor (M-CSF) decreases platelet-activating factor (PAF) acetylhydrolase production in macrophagic J774 cells</title><author>Dupuis, F. ; Dulery, C. ; Praloran, V. ; Denizot, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-5447d6a07a6aec9d68760863db29a12667ca8f7acf12eba58b01adad259b5e903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>1-Alkyl-2-acetylglycerophosphocholine Esterase</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Haematopoiesis</topic><topic>Humans</topic><topic>J774 cells</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - enzymology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular and cellular biology</topic><topic>Phospholipases A - antagonists & inhibitors</topic><topic>Phospholipases A - metabolism</topic><topic>Platelet Activating Factor - metabolism</topic><topic>Platelet-activating factor</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dupuis, F.</creatorcontrib><creatorcontrib>Dulery, C.</creatorcontrib><creatorcontrib>Praloran, V.</creatorcontrib><creatorcontrib>Denizot, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dupuis, F.</au><au>Dulery, C.</au><au>Praloran, V.</au><au>Denizot, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PAF and haematopoiesis XII: macrophage colony-stimulating factor (M-CSF) decreases platelet-activating factor (PAF) acetylhydrolase production in macrophagic J774 cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1996-10-22</date><risdate>1996</risdate><volume>107</volume><issue>2</issue><spage>199</spage><epage>204</epage><pages>199-204</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Platelet-activating factor (PAF) is a phospholipid mediator with major immunoregulatory activities. Macrophages produce PAF acetylhydrolase activity, which regulates blood PAF concentrations. Macrophage colony-stimulating factor (M-CSF) is involved in the differentiation and functions of cells from the monocytic/macrophagic lineage. We found that murine macrophagic J774 cells metabolized PAF with lyso PAF as the major metabolite product. As in mouse plasma, the metabolism of PAF by J774 cells was not inhibited by PMSF, p-BPB, DTNB and quinacrine. M-CSF (100–5000 U/ml) significantly decreased PAF acetylhydrolase activity of the J774 cell without exhibiting a significant effect on cell growth. Elevated concentrations of M-CSF are found in blood and tissues during inflammatory states. It could be suggested that a decreased PAF catabolism by tissue macrophages in response to M-CSF may induce local elevated PAF concentrations, thus amplifying the inflammatory response.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8947513</pmid><doi>10.1016/0304-3835(96)04360-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1996-10, Vol.107 (2), p.199-204 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1-Alkyl-2-acetylglycerophosphocholine Esterase Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Female Fundamental and applied biological sciences. Psychology Haematopoiesis Humans J774 cells Macrophages - drug effects Macrophages - enzymology Mice Mice, Inbred BALB C Molecular and cellular biology Phospholipases A - antagonists & inhibitors Phospholipases A - metabolism Platelet Activating Factor - metabolism Platelet-activating factor Tumor Cells, Cultured |
| title | PAF and haematopoiesis XII: macrophage colony-stimulating factor (M-CSF) decreases platelet-activating factor (PAF) acetylhydrolase production in macrophagic J774 cells |
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