Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma
Serum concentrations of hybridoma growth factor/interleukin-6 progressively increased in mice bearing a transplantable methylcholanthrene-induced sarcoma with tumor growth. Elevated HGF/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic ac...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1988-12, Vol.157 (2), p.575-579 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Gelin, Johan Moldawer, Lyle L. Lonnroth, Christina deMan, Peter Svanborg-Eden, Catharina Lowry, Stephen F. Lundholm, Kent G. |
| description | Serum concentrations of hybridoma growth factor/interleukin-6 progressively increased in mice bearing a transplantable methylcholanthrene-induced sarcoma with tumor growth. Elevated HGF/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic acute phase reactant protein, amyloid P. Daily Indomethacin treatment of sarcoma-bearing mice prolonged survival and reduced the magnitude of the serum amyloid P response, but failed to attenuate either tumor growth or serum HGF/interleukin-6 responses. Since previous studies have demonstrated that neither interleukin-1 nor tumor necrosis factor-alpha can be detected in the serum of these sarcoma-bearing mice, and that HGF/interleukin-6 is a principal mediator of the hepatic acute phase response, we conclude that circulating HGF/interleukin-6 may contribute significantly to the host responses which accompany experimentally-introduced cancer. Furthermore, prostanoid inhibition does not appear to regulate the synthesis and release of HGF/interleukin-6 during tumor growth. |
| doi_str_mv | 10.1016/S0006-291X(88)80288-2 |
| format | Article |
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Elevated HGF/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic acute phase reactant protein, amyloid P. Daily Indomethacin treatment of sarcoma-bearing mice prolonged survival and reduced the magnitude of the serum amyloid P response, but failed to attenuate either tumor growth or serum HGF/interleukin-6 responses. Since previous studies have demonstrated that neither interleukin-1 nor tumor necrosis factor-alpha can be detected in the serum of these sarcoma-bearing mice, and that HGF/interleukin-6 is a principal mediator of the hepatic acute phase response, we conclude that circulating HGF/interleukin-6 may contribute significantly to the host responses which accompany experimentally-introduced cancer. Furthermore, prostanoid inhibition does not appear to regulate the synthesis and release of HGF/interleukin-6 during tumor growth.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(88)80288-2</identifier><identifier>PMID: 3264498</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cell physiology ; Fundamental and applied biological sciences. 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Elevated HGF/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic acute phase reactant protein, amyloid P. Daily Indomethacin treatment of sarcoma-bearing mice prolonged survival and reduced the magnitude of the serum amyloid P response, but failed to attenuate either tumor growth or serum HGF/interleukin-6 responses. Since previous studies have demonstrated that neither interleukin-1 nor tumor necrosis factor-alpha can be detected in the serum of these sarcoma-bearing mice, and that HGF/interleukin-6 is a principal mediator of the hepatic acute phase response, we conclude that circulating HGF/interleukin-6 may contribute significantly to the host responses which accompany experimentally-introduced cancer. Furthermore, prostanoid inhibition does not appear to regulate the synthesis and release of HGF/interleukin-6 during tumor growth.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Indomethacin - pharmacology</subject><subject>Interleukin-6</subject><subject>Interleukins - biosynthesis</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Sarcoma, Experimental - metabolism</subject><subject>Serum Amyloid P-Component - blood</subject><subject>Time Factors</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv3CAUhVHVKp2m_QmRWFRVu3DCZQDjVRVFfUmRukgrdYcwvo5pbTMFnGj-fZiHZpsVQvc7h8M9hFwAuwQG6uqOMaYq3sCfj1p_0oxrXfEXZAWsYRUHJl6S1Ql5Td6k9JcxAKGaM3K25kqIRq_Icr3ZoI12dkhDT4dtG30XJkvvY3jMA-2tyyFe-TljHHH55-dKUT_TPCBNGJdpp5p8UbfFxs_31NIJ87Ad3RBGO-ch4oyVn7vFYUeTja64vyWvejsmfHc8z8nvr19-3Xyvbn9--3FzfVs5wVmuJBeScdZB3YDQPSinOEC7xlpo3QvppJLO2Rq06iz0WC5Msl5w1Wrpmnp9Tj4cfDcx_F8wZTP55HAswTAsydRaaqG0fhYECSWEUAWUB9DFkFLE3myin2zcGmBm14vZ92J2Szdam30vhhfdxfGBpZ2wO6mORZT5--PcJmfHfteITydMqbWQ-w99PmBYtvbgMZrkPJbyOh_RZdMF_0yQJ1TwqqU</recordid><startdate>19881215</startdate><enddate>19881215</enddate><creator>Gelin, Johan</creator><creator>Moldawer, Lyle L.</creator><creator>Lonnroth, Christina</creator><creator>deMan, Peter</creator><creator>Svanborg-Eden, Catharina</creator><creator>Lowry, Stephen F.</creator><creator>Lundholm, Kent G.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19881215</creationdate><title>Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma</title><author>Gelin, Johan ; Moldawer, Lyle L. ; Lonnroth, Christina ; deMan, Peter ; Svanborg-Eden, Catharina ; Lowry, Stephen F. ; Lundholm, Kent G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-5245020d179148f16c6211b3e7488f45c565cca7186da1fe5cc050f426b85c973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Indomethacin - pharmacology</topic><topic>Interleukin-6</topic><topic>Interleukins - biosynthesis</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Sarcoma, Experimental - metabolism</topic><topic>Serum Amyloid P-Component - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gelin, Johan</creatorcontrib><creatorcontrib>Moldawer, Lyle L.</creatorcontrib><creatorcontrib>Lonnroth, Christina</creatorcontrib><creatorcontrib>deMan, Peter</creatorcontrib><creatorcontrib>Svanborg-Eden, Catharina</creatorcontrib><creatorcontrib>Lowry, Stephen F.</creatorcontrib><creatorcontrib>Lundholm, Kent G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gelin, Johan</au><au>Moldawer, Lyle L.</au><au>Lonnroth, Christina</au><au>deMan, Peter</au><au>Svanborg-Eden, Catharina</au><au>Lowry, Stephen F.</au><au>Lundholm, Kent G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1988-12-15</date><risdate>1988</risdate><volume>157</volume><issue>2</issue><spage>575</spage><epage>579</epage><pages>575-579</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Serum concentrations of hybridoma growth factor/interleukin-6 progressively increased in mice bearing a transplantable methylcholanthrene-induced sarcoma with tumor growth. Elevated HGF/interleukin-6 concentrations were also positively correlated with increased serum concentrations of the hepatic acute phase reactant protein, amyloid P. Daily Indomethacin treatment of sarcoma-bearing mice prolonged survival and reduced the magnitude of the serum amyloid P response, but failed to attenuate either tumor growth or serum HGF/interleukin-6 responses. Since previous studies have demonstrated that neither interleukin-1 nor tumor necrosis factor-alpha can be detected in the serum of these sarcoma-bearing mice, and that HGF/interleukin-6 is a principal mediator of the hepatic acute phase response, we conclude that circulating HGF/interleukin-6 may contribute significantly to the host responses which accompany experimentally-introduced cancer. Furthermore, prostanoid inhibition does not appear to regulate the synthesis and release of HGF/interleukin-6 during tumor growth.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3264498</pmid><doi>10.1016/S0006-291X(88)80288-2</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell physiology Fundamental and applied biological sciences. Psychology Indomethacin - pharmacology Interleukin-6 Interleukins - biosynthesis Mice Molecular and cellular biology Responses to growth factors, tumor promotors, other factors Sarcoma, Experimental - metabolism Serum Amyloid P-Component - blood Time Factors |
| title | Appearance of hybridoma growth factor/interleukin-6 in the serum of mice bearing a methylcholanthrene-induced sarcoma |
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