Structure of a DNA Duplex Containing a Single 2‘-O-Methyl-β-d-araT:  Combined Use of NMR, Restrained Molecular Dynamics, and Full Relaxation Matrix Refinement

Two-dimensional 1H NMR spectroscopy was used to determine the solution structure of the double-stranded DNA oligonucleotide d(5‘-CGCATATAGCC-3‘):  d(5‘-GGCTAXATGCG-3‘), where X is 1-(2-O-methyl-β-d-arabinofuranosyl)thymine. The structure determination was based on a total relaxation matrix analysis...

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Veröffentlicht in:	Bioconjugate chemistry 1996-11, Vol.7 (6), p.680-688
Hauptverfasser:	Gotfredsen, Charlotte H, Spielmann, H. Peter, Wengel, Jesper, Jacobsen, Jens Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabinonucleosides - chemistry DNA - chemistry Magnetic Resonance Spectroscopy Models, Molecular Nucleic Acid Conformation Software
Online-Zugang:	Volltext
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