The affinities of prostaglandin H2 and thromboxane A2 for their receptor are similar in washed human platelets

Both thromboxane A2 (TXA2) and its precursor prostaglandin H2 (PGH2) are labile and share a common receptor. The affinities of these two compounds for their putative common receptor are unknown. We compared the potencies of TXA2 and PGH2 to aggregate human platelets and bind to the TXA2/PGH2 recepto...

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Veröffentlicht in:	Biochemical and biophysical research communications 1988-12, Vol.157 (2), p.733-739
Hauptverfasser:	MAYEUX, P. R, MORTON, H. E, GILLARD, J, LORD, A, MORINELLI, T. A, BOEHM, A, MAIS, D. E, HALUSHKA, P. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Binding, Competitive Biological and medical sciences Blood Platelets - metabolism Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Lipids Other biological molecules Platelet Aggregation - drug effects Prostaglandin Endoperoxides - metabolism Prostaglandin Endoperoxides, Synthetic - metabolism Prostaglandin H2 Prostaglandins H - metabolism Radioligand Assay Receptors, Prostaglandin - metabolism Receptors, Thromboxane Receptors, Thromboxane A2, Prostaglandin H2 Thromboxane A2 - metabolism
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