Transplantation and gene transfer of the human glucocerebrosidase gene into immunoselected primate CD34+Thy-1+ cells

In an attempt to improve our gene transfer efficiency into hematopoietic stem cells and to evaluate the capacity of immunoselected CD34+Thy-1+(CDw90) cells to reconstitute hematopoiesis following myeloablation, bone marrow (BM) transplantation was performed using autologous, immunoselected CD34+Thy-...

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Veröffentlicht in:	Blood 1996-12, Vol.88 (11), p.4166-4172
Hauptverfasser:	Donahue, R E, Byrne, E R, Thomas, T E, Kirby, M R, Agricola, B A, Sellers, S E, Gaudernack, G, Karisson, S, Lansdorp, P M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - genetics Adenoviruses, Human - isolation & purification Animals Antigens, CD34 - analysis Bone Marrow Cells CD2 Antigens - analysis CD8 Antigens - analysis Defective Viruses - genetics Defective Viruses - isolation & purification DNA, Recombinant - analysis Gene Transfer Techniques Genetic Vectors - genetics Genetic Vectors - isolation & purification Glucosylceramidase - genetics Graft Survival Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - metabolism Humans Immunomagnetic Separation Lymphocyte Subsets - chemistry Lymphocyte Subsets - immunology Lymphocyte Subsets - virology Macaca mulatta Polymerase Chain Reaction Proviruses - genetics Proviruses - isolation & purification Thy-1 Antigens - analysis Transplantation, Autologous
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