Syntheses of Functionalized Indium Porphyrins for Monoclonal Antibody Labeling
The syntheses and characterizations of five differently hydrosoluble monosubstituted aryl porphyrins are reported. Their metallation with indium-111 was achieved and provided tracers with strong specific activities. The covalent coupling between indium-111 porphyrins and BSA served as a model reacti...
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| Veröffentlicht in: | Bioconjugate chemistry 1996-11, Vol.7 (6), p.617-627 |
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| container_end_page | 627 |
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| container_issue | 6 |
| container_start_page | 617 |
| container_title | Bioconjugate chemistry |
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| creator | Bedel-Cloutour, Catherine H Mauclaire, Laurent Saux, Annie Pereyre, Michel |
| description | The syntheses and characterizations of five differently hydrosoluble monosubstituted aryl porphyrins are reported. Their metallation with indium-111 was achieved and provided tracers with strong specific activities. The covalent coupling between indium-111 porphyrins and BSA served as a model reaction for the definition of the best experimental coupling conditions; the transposition to the labeling of anti-CEA monoclonal antibody was realized. The conjugates exhibited an in vitro good mAb-labeling efficiency, as well as a good preservation of immunoreactivity. |
| doi_str_mv | 10.1021/bc960045i |
| format | Article |
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The conjugates exhibited an in vitro good mAb-labeling efficiency, as well as a good preservation of immunoreactivity.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Cattle</subject><subject>Indium Radioisotopes</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Porphyrins - chemistry</subject><subject>Serum Albumin</subject><issn>1043-1802</issn><issn>1520-4812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhoMoflQP_gBhLwoeVpPdZJMepVhbbLXQeg7JZlaj26Qmu2D99W5p6cnTDLzPvAMPQpcE3xGckXtd9guMKbMH6JSwDKdUkOyw2zHNUyJwdoLOYvzEGPeJyI7RsegzTAU-RS_ztWs-IEJMfJUMW1c21jtV218wydgZ2y6TmQ-rj3WwLiaVD8nUO1_WGyh5cI3V3qyTidJQW_d-jo4qVUe42M0eehs-LgajdPL6NB48TFKVU9GkhDIqjFbUQFkxzfOCgmB9MBVmmaoI52VBCQeijQYmsCYGsxwKwjOuC6PzHrrZ9q6C_24hNnJpYwl1rRz4NkouuitOeQfebsEy-BgDVHIV7FKFtSRYbtzJvbuOvdqVtnoJZk_uZHV5us1tbOBnH6vwJQuecyYXs7l8no6GZJKN5Ia_3vKqjPLTt6FTFv_5-wd654UD</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Bedel-Cloutour, Catherine H</creator><creator>Mauclaire, Laurent</creator><creator>Saux, Annie</creator><creator>Pereyre, Michel</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Syntheses of Functionalized Indium Porphyrins for Monoclonal Antibody Labeling</title><author>Bedel-Cloutour, Catherine H ; Mauclaire, Laurent ; Saux, Annie ; Pereyre, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-14548dba4decf5b7364e859edf052af177c6417e1bdbe580b1d053e61727b6db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Cattle</topic><topic>Indium Radioisotopes</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Porphyrins - chemistry</topic><topic>Serum Albumin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bedel-Cloutour, Catherine H</creatorcontrib><creatorcontrib>Mauclaire, Laurent</creatorcontrib><creatorcontrib>Saux, Annie</creatorcontrib><creatorcontrib>Pereyre, Michel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioconjugate chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bedel-Cloutour, Catherine H</au><au>Mauclaire, Laurent</au><au>Saux, Annie</au><au>Pereyre, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syntheses of Functionalized Indium Porphyrins for Monoclonal Antibody Labeling</atitle><jtitle>Bioconjugate chemistry</jtitle><addtitle>Bioconjugate Chem</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>7</volume><issue>6</issue><spage>617</spage><epage>627</epage><pages>617-627</pages><issn>1043-1802</issn><eissn>1520-4812</eissn><abstract>The syntheses and characterizations of five differently hydrosoluble monosubstituted aryl porphyrins are reported. 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| ispartof | Bioconjugate chemistry, 1996-11, Vol.7 (6), p.617-627 |
| issn | 1043-1802 1520-4812 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78580747 |
| source | MEDLINE; ACS Publications |
| subjects | Animals Antibodies, Monoclonal Cattle Indium Radioisotopes Magnetic Resonance Spectroscopy Porphyrins - chemistry Serum Albumin |
| title | Syntheses of Functionalized Indium Porphyrins for Monoclonal Antibody Labeling |
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