Early clinical experience in reversing benzodiazepine sedation with flumazenil after short procedures
Flumazenil (Flu) (Ro 15-1788, Anexate ®) is a newly synthetized specific benzodiazepine (BZD) antagonist which was recently introduced for clinical study. The drug was intravenously injected, in titrated doses, to patients undergoing diagnostic or therapeutic procedures in order to reverse the sedat...
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| Veröffentlicht in: | Resuscitation 1988, Vol.16, p.S49-S56 |
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| container_title | Resuscitation |
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| creator | Geller, E. Niv, D. Nevo, Y. Leykin, Y. Sorkin, P. Rudick, V. |
| description | Flumazenil (Flu) (Ro 15-1788, Anexate
®) is a newly synthetized specific benzodiazepine (BZD) antagonist which was recently introduced for clinical study. The drug was intravenously injected, in titrated doses, to patients undergoing diagnostic or therapeutic procedures in order to reverse the sedative effects of BZDs. A total of 63 patients undergoing hand surgery under i.v. regional block, lower abdominal surgery under epidural anesthesia, cardiac catheterization, intracardiac catheter ablation, cardioversion, gastroscopy and bronchoscopy were studied. Flu in a dose ranging from 0.1 to 0.42 mg effectively reversed BZD-induced sedation in all patients 1–2 min following i.v. injection. Patients were fully awake and oriented yet calm and in good mood. Flu was well tolerated even in the high risk cardiac patients, with no significant changes in vital signs nor any sign of local irritation at the site of Flu injection. No significant resedation was observed. Thus Flu was very useful in reversing BZD-induced sedation or unconsciousness in a variety of clinical situations: |
| doi_str_mv | 10.1016/0300-9572(88)90005-6 |
| format | Article |
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®) is a newly synthetized specific benzodiazepine (BZD) antagonist which was recently introduced for clinical study. The drug was intravenously injected, in titrated doses, to patients undergoing diagnostic or therapeutic procedures in order to reverse the sedative effects of BZDs. A total of 63 patients undergoing hand surgery under i.v. regional block, lower abdominal surgery under epidural anesthesia, cardiac catheterization, intracardiac catheter ablation, cardioversion, gastroscopy and bronchoscopy were studied. Flu in a dose ranging from 0.1 to 0.42 mg effectively reversed BZD-induced sedation in all patients 1–2 min following i.v. injection. Patients were fully awake and oriented yet calm and in good mood. Flu was well tolerated even in the high risk cardiac patients, with no significant changes in vital signs nor any sign of local irritation at the site of Flu injection. No significant resedation was observed. Thus Flu was very useful in reversing BZD-induced sedation or unconsciousness in a variety of clinical situations:</description><subject>Aged</subject><subject>Anti-Anxiety Agents - antagonists & inhibitors</subject><subject>Benzodiazepine antagonist</subject><subject>Bronchoscopy</subject><subject>Cardiac Catheterization</subject><subject>Double-Blind Method</subject><subject>Electric Countershock</subject><subject>Female</subject><subject>Flumazenil</subject><subject>Flumazenil - therapeutic use</subject><subject>Gastroscopy</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Postoperative Period</subject><subject>Random Allocation</subject><subject>Reversal of sedation</subject><issn>0300-9572</issn><issn>1873-1570</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLxDAUx4Mo47h8A4WcRA_VtGmWXgSRcQHBi57Dm_RVI21ak3ZcPr2dhTl6eof_xvsRcpKyy5Sl8opxxpJCqOxc64uCMSYSuUOmqVY8SYViu2S6teyTgxg_Rg8XhZqQSVawXGoxJTiDUP9QWzvvLNQUvzsMDr1F6jwNuMAQnX-jc_S_bengFzvnkUYsoXetp1-uf6dVPTSj4l1Noeox0Pjehp52obVYDgHjEdmroI54vLmH5PVu9nL7kDw93z_e3jwlNlNZn1hQTHDM8pyr8QGe5XPNy5xJyaEAtKnEKtMcJFgAVLkSElTFKiiLVMyt5ofkbN07Tn8OGHvTuGixrsFjO0SjtNAs12w05mujDW2MASvTBddA-DEpM0u6ZonOLNEZrc2KrpFj7HTTP8wbLLehDc5Rv17rOD65cBhMtCuYpQtoe1O27v-BP86NizM</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Geller, E.</creator><creator>Niv, D.</creator><creator>Nevo, Y.</creator><creator>Leykin, Y.</creator><creator>Sorkin, P.</creator><creator>Rudick, V.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Early clinical experience in reversing benzodiazepine sedation with flumazenil after short procedures</title><author>Geller, E. ; Niv, D. ; Nevo, Y. ; Leykin, Y. ; Sorkin, P. ; Rudick, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-ca7053e24437570324b83d40663a9aec16ef283a6acaae74756a7f0fad915bc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Aged</topic><topic>Anti-Anxiety Agents - antagonists & inhibitors</topic><topic>Benzodiazepine antagonist</topic><topic>Bronchoscopy</topic><topic>Cardiac Catheterization</topic><topic>Double-Blind Method</topic><topic>Electric Countershock</topic><topic>Female</topic><topic>Flumazenil</topic><topic>Flumazenil - therapeutic use</topic><topic>Gastroscopy</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Postoperative Period</topic><topic>Random Allocation</topic><topic>Reversal of sedation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geller, E.</creatorcontrib><creatorcontrib>Niv, D.</creatorcontrib><creatorcontrib>Nevo, Y.</creatorcontrib><creatorcontrib>Leykin, Y.</creatorcontrib><creatorcontrib>Sorkin, P.</creatorcontrib><creatorcontrib>Rudick, V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Resuscitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geller, E.</au><au>Niv, D.</au><au>Nevo, Y.</au><au>Leykin, Y.</au><au>Sorkin, P.</au><au>Rudick, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early clinical experience in reversing benzodiazepine sedation with flumazenil after short procedures</atitle><jtitle>Resuscitation</jtitle><addtitle>Resuscitation</addtitle><date>1988</date><risdate>1988</risdate><volume>16</volume><spage>S49</spage><epage>S56</epage><pages>S49-S56</pages><issn>0300-9572</issn><eissn>1873-1570</eissn><abstract>Flumazenil (Flu) (Ro 15-1788, Anexate
®) is a newly synthetized specific benzodiazepine (BZD) antagonist which was recently introduced for clinical study. The drug was intravenously injected, in titrated doses, to patients undergoing diagnostic or therapeutic procedures in order to reverse the sedative effects of BZDs. A total of 63 patients undergoing hand surgery under i.v. regional block, lower abdominal surgery under epidural anesthesia, cardiac catheterization, intracardiac catheter ablation, cardioversion, gastroscopy and bronchoscopy were studied. Flu in a dose ranging from 0.1 to 0.42 mg effectively reversed BZD-induced sedation in all patients 1–2 min following i.v. injection. Patients were fully awake and oriented yet calm and in good mood. Flu was well tolerated even in the high risk cardiac patients, with no significant changes in vital signs nor any sign of local irritation at the site of Flu injection. No significant resedation was observed. Thus Flu was very useful in reversing BZD-induced sedation or unconsciousness in a variety of clinical situations:</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>2904685</pmid><doi>10.1016/0300-9572(88)90005-6</doi></addata></record> |
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| identifier | ISSN: 0300-9572 |
| ispartof | Resuscitation, 1988, Vol.16, p.S49-S56 |
| issn | 0300-9572 1873-1570 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Anti-Anxiety Agents - antagonists & inhibitors Benzodiazepine antagonist Bronchoscopy Cardiac Catheterization Double-Blind Method Electric Countershock Female Flumazenil Flumazenil - therapeutic use Gastroscopy Hemodynamics - drug effects Humans Injections, Intravenous Male Middle Aged Pilot Projects Postoperative Period Random Allocation Reversal of sedation |
| title | Early clinical experience in reversing benzodiazepine sedation with flumazenil after short procedures |
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