Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes
Despite strong evidence for genetic involvement in the etiology of affective disorders (from twin adoption and family studies), linkage and association methodologies are still exploring the nature of genetic factors in these diseases. Interesting testable hypotheses have been described, including ca...
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| Veröffentlicht in: | American journal of medical genetics 1996-11, Vol.67 (6), p.551-555 |
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| container_title | American journal of medical genetics |
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| creator | Souery, Daniel Lipp, Olivier Mahieu, Brigite Mendelbaum, Karin De Martelaer, Viviane Broeckhoven, Christine Van Mendlewicz, Julien |
| description | Despite strong evidence for genetic involvement in the etiology of affective disorders (from twin adoption and family studies), linkage and association methodologies are still exploring the nature of genetic factors in these diseases. Interesting testable hypotheses have been described, including candidate genes involved in catecholamine neurotransmission. We studied 69 bipolar patients and 69 matched controls (for age, sex, and geographical origin) for association and linkage disequilibrium with DNA markers at the following genes: the tyrosine hydroxylase gene, dopamine transporter gene, and dopamine D2 and D3 receptor genes. Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8628(19961122)67:6<551::AID-AJMG7>3.0.CO;2-K |
| format | Article |
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Interesting testable hypotheses have been described, including candidate genes involved in catecholamine neurotransmission. We studied 69 bipolar patients and 69 matched controls (for age, sex, and geographical origin) for association and linkage disequilibrium with DNA markers at the following genes: the tyrosine hydroxylase gene, dopamine transporter gene, and dopamine D2 and D3 receptor genes. Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample. © 1996 Wiley‐Liss, Inc.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/(SICI)1096-8628(19961122)67:6<551::AID-AJMG7>3.0.CO;2-K</identifier><identifier>PMID: 8950413</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Adult and adolescent clinical studies ; Alleles ; Biological and medical sciences ; bipolar affective disorder ; Bipolar Disorder - genetics ; Bipolar disorders ; candidate genes ; Carrier Proteins - genetics ; catecholamine neurotransmission ; Dopamine - metabolism ; Dopamine Plasma Membrane Transport Proteins ; Female ; Genetic Linkage ; Genetic Markers ; Genotype ; Humans ; linkage disequilibrium ; Male ; Medical sciences ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Middle Aged ; Mood disorders ; Nerve Tissue Proteins - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptors, Dopamine D2 - genetics ; Receptors, Dopamine D3 ; Sequence Analysis, DNA ; Tyrosine 3-Monooxygenase - genetics</subject><ispartof>American journal of medical genetics, 1996-11, Vol.67 (6), p.551-555</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc.</rights><rights>1997 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3807-43b311137718e8d383f03cb8fd0fde704eea0dff2c56fdaaa2e226022de88b453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2515539$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8950413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souery, Daniel</creatorcontrib><creatorcontrib>Lipp, Olivier</creatorcontrib><creatorcontrib>Mahieu, Brigite</creatorcontrib><creatorcontrib>Mendelbaum, Karin</creatorcontrib><creatorcontrib>De Martelaer, Viviane</creatorcontrib><creatorcontrib>Broeckhoven, Christine Van</creatorcontrib><creatorcontrib>Mendlewicz, Julien</creatorcontrib><title>Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Despite strong evidence for genetic involvement in the etiology of affective disorders (from twin adoption and family studies), linkage and association methodologies are still exploring the nature of genetic factors in these diseases. Interesting testable hypotheses have been described, including candidate genes involved in catecholamine neurotransmission. We studied 69 bipolar patients and 69 matched controls (for age, sex, and geographical origin) for association and linkage disequilibrium with DNA markers at the following genes: the tyrosine hydroxylase gene, dopamine transporter gene, and dopamine D2 and D3 receptor genes. Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample. © 1996 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>bipolar affective disorder</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar disorders</subject><subject>candidate genes</subject><subject>Carrier Proteins - genetics</subject><subject>catecholamine neurotransmission</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Plasma Membrane Transport Proteins</subject><subject>Female</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Genotype</subject><subject>Humans</subject><subject>linkage disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Dopamine D2 - genetics</subject><subject>Receptors, Dopamine D3</subject><subject>Sequence Analysis, DNA</subject><subject>Tyrosine 3-Monooxygenase - genetics</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1v0zAUhiMEGmXwE5B8gdAmLcUfceIUBOpa6Mo2KkHRuDty4xNmSJNipxv9A_xuXFJ6AxLcOJHPex698hNFrxjtM0r5s6MP09H0mNE8jVXK1RHL85Qxzo_TbJC-kJINBsPpOB6-vZxkL0Wf9kez5zw-vxP19jt3ox5liYoznuf3owfef6GUhQt-EB2oXNKEiV70Y-h9U1jd2qYmvl2bDWlKsrCrptKOGOsbZ9CRW9tek0LXxhrdIvmMNXpi65umukETfsKsxeI6LC1tjaTGtWtap2u_tN4H9ICM34_5yfYU4RzO2QkJNDI_61gPo3ulrjw-2n0Po49vXs9HZ_HFbDIdDS_iQiiaxYlYCMaYyDKmUBmhRElFsVCloaXBjCaImpqy5IVMS6O15sh5Sjk3qNQikeIwetpxV675tkbfQihYYFXpGpu1h0xJRZP_CDKpMsm4CMGrLli4xnuHJaycXWq3AUZhqxJgqxK2WmCrBX6rhDSDFIJKgKASfqkEARRGM-BwHsiPdxXWiyWaPXfnLsyf7ObaF7oqw3MX1u9jXDIpRR5in7rYra1w80e7f5b7W7fuIqDjDm19i9_3aO2-hnWRSbh6NwGhJvOUnZ7CpfgJDQnV4w</recordid><startdate>19961122</startdate><enddate>19961122</enddate><creator>Souery, Daniel</creator><creator>Lipp, Olivier</creator><creator>Mahieu, Brigite</creator><creator>Mendelbaum, Karin</creator><creator>De Martelaer, Viviane</creator><creator>Broeckhoven, Christine Van</creator><creator>Mendlewicz, Julien</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19961122</creationdate><title>Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes</title><author>Souery, Daniel ; Lipp, Olivier ; Mahieu, Brigite ; Mendelbaum, Karin ; De Martelaer, Viviane ; Broeckhoven, Christine Van ; Mendlewicz, Julien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3807-43b311137718e8d383f03cb8fd0fde704eea0dff2c56fdaaa2e226022de88b453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>bipolar affective disorder</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar disorders</topic><topic>candidate genes</topic><topic>Carrier Proteins - genetics</topic><topic>catecholamine neurotransmission</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Plasma Membrane Transport Proteins</topic><topic>Female</topic><topic>Genetic Linkage</topic><topic>Genetic Markers</topic><topic>Genotype</topic><topic>Humans</topic><topic>linkage disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Transport Proteins</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Adult and adolescent clinical studies Alleles Biological and medical sciences bipolar affective disorder Bipolar Disorder - genetics Bipolar disorders candidate genes Carrier Proteins - genetics catecholamine neurotransmission Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Female Genetic Linkage Genetic Markers Genotype Humans linkage disequilibrium Male Medical sciences Membrane Glycoproteins - genetics Membrane Transport Proteins Middle Aged Mood disorders Nerve Tissue Proteins - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D2 - genetics Receptors, Dopamine D3 Sequence Analysis, DNA Tyrosine 3-Monooxygenase - genetics |
| title | Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes |
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