Photoaffinity labeling of mefloquine-binding proteins in human serum, uninfected erythrocytes and Plasmodium falciparum-infected erythrocytes

A photoreactive quinolinemethanol analog, N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azido-2-salicylamide (ASA-MQ) has been synthesized which closely mimics the action of mefloquine. ASA-MQ possesses potent antimalarial activity against a mefloquine-sensitive strain of Plasmodium falcipa...

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Veröffentlicht in:	Molecular and biochemical parasitology 1996-11, Vol.82 (2), p.181-194
Hauptverfasser:	Desneves, José, Thorn, Gabrielle, Berman, Ann, Galatis, Denise, La Greca, Nadia, Sinding, Jens, Foley, Michael, Deady, Leslie W., Cowman, Alan F., Tilley, Leann
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Animals Antimalarials - metabolism Apo-A1 Apolipoprotein A-I - metabolism Band 7.2b Blood Proteins - metabolism Drug Resistance Erythrocyte Membrane - metabolism Humans Malaria Mefloquine Mefloquine - analogs & derivatives Mefloquine - metabolism Mefloquine - pharmacology Membrane Proteins Photoaffinity labeling Plasmodium falciparum Plasmodium falciparum - metabolism Protozoan Proteins - metabolism Quinoline antimalarials
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