The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), p...

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Veröffentlicht in:	Cell 1996-11, Vol.87 (5), p.953-959
Hauptverfasser:	Ogryzko, Vasily V, Schiltz, R.Louis, Russanova, Valya, Howard, Bruce H, Nakatani, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferases - metabolism Adenoviridae - enzymology Amino Acid Sequence CREB-Binding Protein Histones - chemistry Histones - metabolism Lysine - metabolism Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - metabolism Nucleosomes - chemistry Nucleosomes - enzymology Phosphorylation Protein Structure, Tertiary Trans-Activators Transcription Factors - chemistry Transcription Factors - metabolism Transcription, Genetic - physiology Viral Proteins - metabolism
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