New 5′-Nucleotidase Inhibitors, NPF-86IA, NPF-86IB, NPF-86IIA, and NPF-86IIB from Areca catechu; Part II. Anti-Tumor Effects

Abstract New 5′-nucleotidase inhibitors, NPF-86IA, NPF-86IB, NPF-86IIA, and NPF-86IIB were isolated from a plant origin. According to their physico-chemical properties, these compounds are polyphenolic substances. These inhibitors displayed significant therapeutic activity by intraperitoneally administration against intraperitoneally inplanted Ehrlich ascites carcinoma. IN VITRO, these inhibitors exhibited a moderate cytotoxicity to Ehrlich ascites carcinoma strain E, HeLa, and HL-60 cells. However, these 5′-nucleotidase inhibitors did not show an anti-tumor effects on L1210 cells IN VIVO and IN VITRO.