Anaesthesia for intra‐peritoneal perfusion of hyperthermic chemotherapy Haemodynamic changes, oxygen consumption and delivery
Summary We investigated the intra‐operative application of intraperitoneal perfusion of hyperthermic chemotherapy and its effects on cardiovascular status and oxygen consumption and delivery in 11 patients following laparotomy for surgical resection of recurrent tumours or peritoneal metastases. Clo...
Gespeichert in:
| Veröffentlicht in: | Anaesthesia 1996-11, Vol.51 (11), p.1033-1036 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1036 |
|---|---|
| container_issue | 11 |
| container_start_page | 1033 |
| container_title | Anaesthesia |
| container_volume | 51 |
| creator | KANAKOUDIS, F. PETROU, A. MICHALOUDIS, D. CHORTARIA, G. KONSTANTINIDOU, A. |
| description | Summary
We investigated the intra‐operative application of intraperitoneal perfusion of hyperthermic chemotherapy and its effects on cardiovascular status and oxygen consumption and delivery in 11 patients following laparotomy for surgical resection of recurrent tumours or peritoneal metastases. Closed peritoneal irrigation was carried out with perfusate at a temperature of 45–47°C. External cooling was applied during the procedure to prevent systemic hyperthermia. Data were collected 5 min before the commencement of the hyperthermic peritoneal perfusion, at 5, 30, 60 and 90 mm during perfusion and 5 min after perfusion was discontinued. During the hyperthermic perfusion period, the core body temperature increased significantly but remained within clinically acceptable values. Heart rate, central venous pressure and pulmonary artery pressure increased significantly during perfusion; these returned to control values immediately after discontinuation of perfusion, except for the heart rate, which remained high. Mean arterial pressure, cardiac output, oxygen delivery and oxygen consumption did not change significantly although a metabolic acidosis developed during the study period. These findings suggest that the intraperitoneal perfusion of hyperthermic chemotherapy may be safe in humans, provided that appropriate monitoring, cooling and technical support are applied. |
| doi_str_mv | 10.1111/j.1365-2044.1996.tb14998.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78574923</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78574923</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3843-cf148cd0b6ba01fb4c01923868d6645e484a1ec2b9fc7b0bf0217e7e005715cb3</originalsourceid><addsrcrecordid>eNqVkNGO1CAYhYnRrLOrj2BCjPFqO0KhLfVqJ5vVNdnojV4TSn92mLRQodXplT6Cz-iTSDPN3MsNnJzzH-BD6DUlW5rWu8OWsrLIcsL5ltZ1uR0byutabI9P0OZsPUUbQgjLck7q5-gyxgMhNBdUXKALUXNW1HyDfu2cgjjuIVqFjQ_YujGov7__DBDs6B2oDqejmaL1DnuD93OSKR96q7HeQ-8XoYYZ36sk2tmpk6PcI8Rr7I_zIzisvYtTP4xLi3ItbqGzPyDML9Azo7oIL9f9Cn37cPf19j57-PLx0-3uIdNMcJZpQ7nQLWnKRhFqGq4JrXMmStGWJS-AC64o6Lypja4a0hiS0woqIKSoaKEbdoXennqH4L9P6ceyt1FD1ykHfoqyEkXFU2MKvj8FdfAxBjByCLZXYZaUyIW-PMgFsVwQy4W-XOnLYxp-td4yNT2059EVd_LfrL6KWnUmKKdtPMdYXlDGqhS7OcV-2g7m_3iA3H3e3VHCGPsH5UKmqQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78574923</pqid></control><display><type>article</type><title>Anaesthesia for intra‐peritoneal perfusion of hyperthermic chemotherapy Haemodynamic changes, oxygen consumption and delivery</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>KANAKOUDIS, F. ; PETROU, A. ; MICHALOUDIS, D. ; CHORTARIA, G. ; KONSTANTINIDOU, A.</creator><creatorcontrib>KANAKOUDIS, F. ; PETROU, A. ; MICHALOUDIS, D. ; CHORTARIA, G. ; KONSTANTINIDOU, A.</creatorcontrib><description>Summary
We investigated the intra‐operative application of intraperitoneal perfusion of hyperthermic chemotherapy and its effects on cardiovascular status and oxygen consumption and delivery in 11 patients following laparotomy for surgical resection of recurrent tumours or peritoneal metastases. Closed peritoneal irrigation was carried out with perfusate at a temperature of 45–47°C. External cooling was applied during the procedure to prevent systemic hyperthermia. Data were collected 5 min before the commencement of the hyperthermic peritoneal perfusion, at 5, 30, 60 and 90 mm during perfusion and 5 min after perfusion was discontinued. During the hyperthermic perfusion period, the core body temperature increased significantly but remained within clinically acceptable values. Heart rate, central venous pressure and pulmonary artery pressure increased significantly during perfusion; these returned to control values immediately after discontinuation of perfusion, except for the heart rate, which remained high. Mean arterial pressure, cardiac output, oxygen delivery and oxygen consumption did not change significantly although a metabolic acidosis developed during the study period. These findings suggest that the intraperitoneal perfusion of hyperthermic chemotherapy may be safe in humans, provided that appropriate monitoring, cooling and technical support are applied.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.1996.tb14998.x</identifier><identifier>PMID: 8943594</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Anaesthesia ; Antineoplastic agents ; Antineoplastic Agents - administration & dosage ; Biological and medical sciences ; Blood Pressure ; Central Venous Pressure ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Female ; Heart Rate ; Humans ; Hyperthermia, Induced ; Infusions, Parenteral ; intraperitoneal hyperthalamic perfusion ; Male ; Medical sciences ; Middle Aged ; Ovarian Neoplasms - drug therapy ; Oxygen - administration & dosage ; Peritoneal Neoplasms - drug therapy ; Peritoneal Neoplasms - secondary ; Pharmacology. Drug treatments ; Stomach Neoplasms - drug therapy ; Time Factors ; Treatment Outcome</subject><ispartof>Anaesthesia, 1996-11, Vol.51 (11), p.1033-1036</ispartof><rights>1996 The Association of Anaesthetists of Great Britain and Ireland</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3843-cf148cd0b6ba01fb4c01923868d6645e484a1ec2b9fc7b0bf0217e7e005715cb3</citedby><cites>FETCH-LOGICAL-c3843-cf148cd0b6ba01fb4c01923868d6645e484a1ec2b9fc7b0bf0217e7e005715cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.1996.tb14998.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.1996.tb14998.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3251337$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8943594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KANAKOUDIS, F.</creatorcontrib><creatorcontrib>PETROU, A.</creatorcontrib><creatorcontrib>MICHALOUDIS, D.</creatorcontrib><creatorcontrib>CHORTARIA, G.</creatorcontrib><creatorcontrib>KONSTANTINIDOU, A.</creatorcontrib><title>Anaesthesia for intra‐peritoneal perfusion of hyperthermic chemotherapy Haemodynamic changes, oxygen consumption and delivery</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
We investigated the intra‐operative application of intraperitoneal perfusion of hyperthermic chemotherapy and its effects on cardiovascular status and oxygen consumption and delivery in 11 patients following laparotomy for surgical resection of recurrent tumours or peritoneal metastases. Closed peritoneal irrigation was carried out with perfusate at a temperature of 45–47°C. External cooling was applied during the procedure to prevent systemic hyperthermia. Data were collected 5 min before the commencement of the hyperthermic peritoneal perfusion, at 5, 30, 60 and 90 mm during perfusion and 5 min after perfusion was discontinued. During the hyperthermic perfusion period, the core body temperature increased significantly but remained within clinically acceptable values. Heart rate, central venous pressure and pulmonary artery pressure increased significantly during perfusion; these returned to control values immediately after discontinuation of perfusion, except for the heart rate, which remained high. Mean arterial pressure, cardiac output, oxygen delivery and oxygen consumption did not change significantly although a metabolic acidosis developed during the study period. These findings suggest that the intraperitoneal perfusion of hyperthermic chemotherapy may be safe in humans, provided that appropriate monitoring, cooling and technical support are applied.</description><subject>Adult</subject><subject>Aged</subject><subject>Anaesthesia</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Central Venous Pressure</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Hyperthermia, Induced</subject><subject>Infusions, Parenteral</subject><subject>intraperitoneal hyperthalamic perfusion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Oxygen - administration & dosage</subject><subject>Peritoneal Neoplasms - drug therapy</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Pharmacology. Drug treatments</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNGO1CAYhYnRrLOrj2BCjPFqO0KhLfVqJ5vVNdnojV4TSn92mLRQodXplT6Cz-iTSDPN3MsNnJzzH-BD6DUlW5rWu8OWsrLIcsL5ltZ1uR0byutabI9P0OZsPUUbQgjLck7q5-gyxgMhNBdUXKALUXNW1HyDfu2cgjjuIVqFjQ_YujGov7__DBDs6B2oDqejmaL1DnuD93OSKR96q7HeQ-8XoYYZ36sk2tmpk6PcI8Rr7I_zIzisvYtTP4xLi3ItbqGzPyDML9Azo7oIL9f9Cn37cPf19j57-PLx0-3uIdNMcJZpQ7nQLWnKRhFqGq4JrXMmStGWJS-AC64o6Lypja4a0hiS0woqIKSoaKEbdoXennqH4L9P6ceyt1FD1ykHfoqyEkXFU2MKvj8FdfAxBjByCLZXYZaUyIW-PMgFsVwQy4W-XOnLYxp-td4yNT2059EVd_LfrL6KWnUmKKdtPMdYXlDGqhS7OcV-2g7m_3iA3H3e3VHCGPsH5UKmqQ</recordid><startdate>199611</startdate><enddate>199611</enddate><creator>KANAKOUDIS, F.</creator><creator>PETROU, A.</creator><creator>MICHALOUDIS, D.</creator><creator>CHORTARIA, G.</creator><creator>KONSTANTINIDOU, A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199611</creationdate><title>Anaesthesia for intra‐peritoneal perfusion of hyperthermic chemotherapy Haemodynamic changes, oxygen consumption and delivery</title><author>KANAKOUDIS, F. ; PETROU, A. ; MICHALOUDIS, D. ; CHORTARIA, G. ; KONSTANTINIDOU, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3843-cf148cd0b6ba01fb4c01923868d6645e484a1ec2b9fc7b0bf0217e7e005715cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anaesthesia</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Central Venous Pressure</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Hyperthermia, Induced</topic><topic>Infusions, Parenteral</topic><topic>intraperitoneal hyperthalamic perfusion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Oxygen - administration & dosage</topic><topic>Peritoneal Neoplasms - drug therapy</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Pharmacology. Drug treatments</topic><topic>Stomach Neoplasms - drug therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KANAKOUDIS, F.</creatorcontrib><creatorcontrib>PETROU, A.</creatorcontrib><creatorcontrib>MICHALOUDIS, D.</creatorcontrib><creatorcontrib>CHORTARIA, G.</creatorcontrib><creatorcontrib>KONSTANTINIDOU, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KANAKOUDIS, F.</au><au>PETROU, A.</au><au>MICHALOUDIS, D.</au><au>CHORTARIA, G.</au><au>KONSTANTINIDOU, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaesthesia for intra‐peritoneal perfusion of hyperthermic chemotherapy Haemodynamic changes, oxygen consumption and delivery</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>1996-11</date><risdate>1996</risdate><volume>51</volume><issue>11</issue><spage>1033</spage><epage>1036</epage><pages>1033-1036</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
We investigated the intra‐operative application of intraperitoneal perfusion of hyperthermic chemotherapy and its effects on cardiovascular status and oxygen consumption and delivery in 11 patients following laparotomy for surgical resection of recurrent tumours or peritoneal metastases. Closed peritoneal irrigation was carried out with perfusate at a temperature of 45–47°C. External cooling was applied during the procedure to prevent systemic hyperthermia. Data were collected 5 min before the commencement of the hyperthermic peritoneal perfusion, at 5, 30, 60 and 90 mm during perfusion and 5 min after perfusion was discontinued. During the hyperthermic perfusion period, the core body temperature increased significantly but remained within clinically acceptable values. Heart rate, central venous pressure and pulmonary artery pressure increased significantly during perfusion; these returned to control values immediately after discontinuation of perfusion, except for the heart rate, which remained high. Mean arterial pressure, cardiac output, oxygen delivery and oxygen consumption did not change significantly although a metabolic acidosis developed during the study period. These findings suggest that the intraperitoneal perfusion of hyperthermic chemotherapy may be safe in humans, provided that appropriate monitoring, cooling and technical support are applied.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8943594</pmid><doi>10.1111/j.1365-2044.1996.tb14998.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2409 |
| ispartof | Anaesthesia, 1996-11, Vol.51 (11), p.1033-1036 |
| issn | 0003-2409 1365-2044 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78574923 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Anaesthesia Antineoplastic agents Antineoplastic Agents - administration & dosage Biological and medical sciences Blood Pressure Central Venous Pressure Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Female Heart Rate Humans Hyperthermia, Induced Infusions, Parenteral intraperitoneal hyperthalamic perfusion Male Medical sciences Middle Aged Ovarian Neoplasms - drug therapy Oxygen - administration & dosage Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Pharmacology. Drug treatments Stomach Neoplasms - drug therapy Time Factors Treatment Outcome |
| title | Anaesthesia for intra‐peritoneal perfusion of hyperthermic chemotherapy Haemodynamic changes, oxygen consumption and delivery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T23%3A45%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anaesthesia%20for%20intra%E2%80%90peritoneal%20perfusion%20of%20hyperthermic%20chemotherapy%20Haemodynamic%20changes,%20oxygen%20consumption%20and%20delivery&rft.jtitle=Anaesthesia&rft.au=KANAKOUDIS,%20F.&rft.date=1996-11&rft.volume=51&rft.issue=11&rft.spage=1033&rft.epage=1036&rft.pages=1033-1036&rft.issn=0003-2409&rft.eissn=1365-2044&rft.coden=ANASAB&rft_id=info:doi/10.1111/j.1365-2044.1996.tb14998.x&rft_dat=%3Cproquest_cross%3E78574923%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78574923&rft_id=info:pmid/8943594&rfr_iscdi=true |