Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination
Paracetamol and diclofenac have different mechanisms of action, and the combination may be more effective than each drug used alone in treating postoperative pain. In a double-blind, controlled design, we studied 60 patients undergoing elective abdominal gynaecological surgery, who received supposit...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1996-10, Vol.77 (4), p.445-447 |
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| container_end_page | 447 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | Montgomery, J E Sutherland, C J Kestin, I G Sneyd, J R |
| description | Paracetamol and diclofenac have different mechanisms of action, and the combination may be more effective than each drug used alone in treating postoperative pain. In a double-blind, controlled design, we studied 60 patients undergoing elective abdominal gynaecological surgery, who received suppositories of paracetamol 1.5 g, diclofenac 100 mg or a combination of the two before the start of surgery. Patients received morphine in the intraoperative period, and cumulative morphine use from a patient-controlled analgesia system was recorded to measure the analgesic effect of the suppositories. Morphine consumption was greatest in the group that received paracetamol alone and lowest in the group given the combination (P < 0.01). There was no difference in the incidence of morphine-related side effects between the groups. We conclude that a diclofenac-paracetamol combination reduced the amount of morphine used compared with paracetamol alone. |
| doi_str_mv | 10.1093/bja/77.4.445 |
| format | Article |
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In a double-blind, controlled design, we studied 60 patients undergoing elective abdominal gynaecological surgery, who received suppositories of paracetamol 1.5 g, diclofenac 100 mg or a combination of the two before the start of surgery. Patients received morphine in the intraoperative period, and cumulative morphine use from a patient-controlled analgesia system was recorded to measure the analgesic effect of the suppositories. Morphine consumption was greatest in the group that received paracetamol alone and lowest in the group given the combination (P < 0.01). There was no difference in the incidence of morphine-related side effects between the groups. We conclude that a diclofenac-paracetamol combination reduced the amount of morphine used compared with paracetamol alone.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/77.4.445</identifier><identifier>PMID: 8942325</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acetaminophen - therapeutic use ; Adult ; Analgesia, Patient-Controlled ; Analgesics ; Analgesics, Non-Narcotic - therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Diclofenac - therapeutic use ; Double-Blind Method ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Humans ; Medical sciences ; Middle Aged ; Morphine - administration & dosage ; Neuropharmacology ; Pain, Postoperative - prevention & control ; Pharmacology. Drug treatments ; Prospective Studies ; Suppositories</subject><ispartof>British journal of anaesthesia : BJA, 1996-10, Vol.77 (4), p.445-447</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright British Medical Association Oct 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-61548b59e85df866ed97ab3dd5478e17170a5419f75a9b4963ed68b797ffae63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3232100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8942325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montgomery, J E</creatorcontrib><creatorcontrib>Sutherland, C J</creatorcontrib><creatorcontrib>Kestin, I G</creatorcontrib><creatorcontrib>Sneyd, J R</creatorcontrib><title>Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>Paracetamol and diclofenac have different mechanisms of action, and the combination may be more effective than each drug used alone in treating postoperative pain. In a double-blind, controlled design, we studied 60 patients undergoing elective abdominal gynaecological surgery, who received suppositories of paracetamol 1.5 g, diclofenac 100 mg or a combination of the two before the start of surgery. Patients received morphine in the intraoperative period, and cumulative morphine use from a patient-controlled analgesia system was recorded to measure the analgesic effect of the suppositories. Morphine consumption was greatest in the group that received paracetamol alone and lowest in the group given the combination (P < 0.01). There was no difference in the incidence of morphine-related side effects between the groups. We conclude that a diclofenac-paracetamol combination reduced the amount of morphine used compared with paracetamol alone.</description><subject>Acetaminophen - therapeutic use</subject><subject>Adult</subject><subject>Analgesia, Patient-Controlled</subject><subject>Analgesics</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Diclofenac - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine - administration & dosage</subject><subject>Neuropharmacology</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Prospective Studies</topic><topic>Suppositories</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montgomery, J E</creatorcontrib><creatorcontrib>Sutherland, C J</creatorcontrib><creatorcontrib>Kestin, I G</creatorcontrib><creatorcontrib>Sneyd, J R</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montgomery, J E</au><au>Sutherland, C J</au><au>Kestin, I G</au><au>Sneyd, J R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>77</volume><issue>4</issue><spage>445</spage><epage>447</epage><pages>445-447</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Paracetamol and diclofenac have different mechanisms of action, and the combination may be more effective than each drug used alone in treating postoperative pain. In a double-blind, controlled design, we studied 60 patients undergoing elective abdominal gynaecological surgery, who received suppositories of paracetamol 1.5 g, diclofenac 100 mg or a combination of the two before the start of surgery. Patients received morphine in the intraoperative period, and cumulative morphine use from a patient-controlled analgesia system was recorded to measure the analgesic effect of the suppositories. Morphine consumption was greatest in the group that received paracetamol alone and lowest in the group given the combination (P < 0.01). There was no difference in the incidence of morphine-related side effects between the groups. We conclude that a diclofenac-paracetamol combination reduced the amount of morphine used compared with paracetamol alone.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8942325</pmid><doi>10.1093/bja/77.4.445</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of anaesthesia : BJA, 1996-10, Vol.77 (4), p.445-447 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acetaminophen - therapeutic use Adult Analgesia, Patient-Controlled Analgesics Analgesics, Non-Narcotic - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Diclofenac - therapeutic use Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Female Humans Medical sciences Middle Aged Morphine - administration & dosage Neuropharmacology Pain, Postoperative - prevention & control Pharmacology. Drug treatments Prospective Studies Suppositories |
| title | Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination |
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