Arachidonic Acid Metabolites: Basic Concepts Relevant to Plastic Surgery
AA is the precursor of oxygenated metabolites called the eicosanoids, that are generated by the cyclooxygenase, lipoxygenase, or cytochrome P450 enzymatic pathways. The biologically active eicosanoids are labile, usually but not always, act near their site of synthesis, and are not stored in any tis...
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| Veröffentlicht in: | Journal of reconstructive microsurgery 1988-10, Vol.4 (5), p.421-426 |
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| container_title | Journal of reconstructive microsurgery |
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| creator | Proctor, Kenneth G. Shatkin, Samuel |
| description | AA is the precursor of oxygenated metabolites called the eicosanoids, that are generated by the cyclooxygenase, lipoxygenase, or cytochrome P450 enzymatic pathways. The biologically active eicosanoids are labile, usually but not always, act near their site of synthesis, and are not stored in any tissue to any appreciable degree. In most tissues, there is a continuous low-level synthesis that is probably essential to normal function. Injury or surgical trauma can evoke a dramatic change in the quality and quantity of the metabolites. Pharmacologic manipulation of the pathways of AA metabolism, or alteration of the effects of AA metabolites, can significantly improve tissue perfusion in a variety of clinical situations. (See Figure 1 for a schematic summary of the pathways involved in arachidonic acid metabolites. |
| doi_str_mv | 10.1055/s-2007-1006954 |
| format | Article |
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The biologically active eicosanoids are labile, usually but not always, act near their site of synthesis, and are not stored in any tissue to any appreciable degree. In most tissues, there is a continuous low-level synthesis that is probably essential to normal function. Injury or surgical trauma can evoke a dramatic change in the quality and quantity of the metabolites. Pharmacologic manipulation of the pathways of AA metabolism, or alteration of the effects of AA metabolites, can significantly improve tissue perfusion in a variety of clinical situations. (See Figure 1 for a schematic summary of the pathways involved in arachidonic acid metabolites.</description><identifier>ISSN: 0743-684X</identifier><identifier>EISSN: 1098-8947</identifier><identifier>DOI: 10.1055/s-2007-1006954</identifier><identifier>PMID: 3143831</identifier><identifier>CODEN: JRMIE2</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Animals ; Arachidonic Acid ; Arachidonic Acids ; BASIC SCIENCE REVIEW ; Biological and medical sciences ; Burns - physiopathology ; Diet ; Humans ; Leukotrienes - physiology ; Medical sciences ; Microcirculation ; Orthopedic surgery ; Prostaglandins - physiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery, Plastic ; Surgical Flaps ; Thromboxanes - physiology</subject><ispartof>Journal of reconstructive microsurgery, 1988-10, Vol.4 (5), p.421-426</ispartof><rights>1988 by Thieme Medical Publishers, Inc.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2724-dc1c71b1491b1359f2ebc83e8d33f93c447a8f7f7e8ab0ccd55c9951af70eba13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1006954.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-1006954$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3016,3017,27923,27924,54558,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6702793$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3143831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Proctor, Kenneth G.</creatorcontrib><creatorcontrib>Shatkin, Samuel</creatorcontrib><title>Arachidonic Acid Metabolites: Basic Concepts Relevant to Plastic Surgery</title><title>Journal of reconstructive microsurgery</title><addtitle>J reconstr Microsurg</addtitle><description>AA is the precursor of oxygenated metabolites called the eicosanoids, that are generated by the cyclooxygenase, lipoxygenase, or cytochrome P450 enzymatic pathways. The biologically active eicosanoids are labile, usually but not always, act near their site of synthesis, and are not stored in any tissue to any appreciable degree. In most tissues, there is a continuous low-level synthesis that is probably essential to normal function. Injury or surgical trauma can evoke a dramatic change in the quality and quantity of the metabolites. Pharmacologic manipulation of the pathways of AA metabolism, or alteration of the effects of AA metabolites, can significantly improve tissue perfusion in a variety of clinical situations. (See Figure 1 for a schematic summary of the pathways involved in arachidonic acid metabolites.</description><subject>Animals</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids</subject><subject>BASIC SCIENCE REVIEW</subject><subject>Biological and medical sciences</subject><subject>Burns - physiopathology</subject><subject>Diet</subject><subject>Humans</subject><subject>Leukotrienes - physiology</subject><subject>Medical sciences</subject><subject>Microcirculation</subject><subject>Orthopedic surgery</subject><subject>Prostaglandins - physiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery, Plastic</subject><subject>Surgical Flaps</subject><subject>Thromboxanes - physiology</subject><issn>0743-684X</issn><issn>1098-8947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LwzAYh4Moc35cvQk9iLfMpEmXxNsc6oSJ4gd4C2n6xnV07UxSYf-9HSu7eXrh_T3vBw9CF5SMKMmym4BTQgSmhIxVxg_QkBIlsVRcHKIhEZzhseRfx-gkhCUhlCuaDtCAUc4ko0M0m3hjF2XR1KVNJrYskmeIJm-qMkK4Te5M6PrTprawjiF5gwp-TR2T2CSvlQmxC99b_w1-c4aOnKkCnPf1FH0-3H9MZ3j-8vg0ncyxTUXKcWGpFTTf_pFTlimXQm4lA1kw5hSznAsjnXACpMmJtUWWWaUyapwgkBvKTtH1bu_aNz8thKhXZbBQVaaGpg1ayEykivEOHO1A65sQPDi99uXK-I2mRG_V6aC36nSvrhu47De3-QqKPd676vKrPjfBmsp5U9sy7LGxIKlQrMPwDouLElagl03r687If2f_APIdg64</recordid><startdate>198810</startdate><enddate>198810</enddate><creator>Proctor, Kenneth G.</creator><creator>Shatkin, Samuel</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198810</creationdate><title>Arachidonic Acid Metabolites: Basic Concepts Relevant to Plastic Surgery</title><author>Proctor, Kenneth G. ; Shatkin, Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2724-dc1c71b1491b1359f2ebc83e8d33f93c447a8f7f7e8ab0ccd55c9951af70eba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acids</topic><topic>BASIC SCIENCE REVIEW</topic><topic>Biological and medical sciences</topic><topic>Burns - physiopathology</topic><topic>Diet</topic><topic>Humans</topic><topic>Leukotrienes - physiology</topic><topic>Medical sciences</topic><topic>Microcirculation</topic><topic>Orthopedic surgery</topic><topic>Prostaglandins - physiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery, Plastic</topic><topic>Surgical Flaps</topic><topic>Thromboxanes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Proctor, Kenneth G.</creatorcontrib><creatorcontrib>Shatkin, Samuel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reconstructive microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Proctor, Kenneth G.</au><au>Shatkin, Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arachidonic Acid Metabolites: Basic Concepts Relevant to Plastic Surgery</atitle><jtitle>Journal of reconstructive microsurgery</jtitle><addtitle>J reconstr Microsurg</addtitle><date>1988-10</date><risdate>1988</risdate><volume>4</volume><issue>5</issue><spage>421</spage><epage>426</epage><pages>421-426</pages><issn>0743-684X</issn><eissn>1098-8947</eissn><coden>JRMIE2</coden><abstract>AA is the precursor of oxygenated metabolites called the eicosanoids, that are generated by the cyclooxygenase, lipoxygenase, or cytochrome P450 enzymatic pathways. The biologically active eicosanoids are labile, usually but not always, act near their site of synthesis, and are not stored in any tissue to any appreciable degree. In most tissues, there is a continuous low-level synthesis that is probably essential to normal function. Injury or surgical trauma can evoke a dramatic change in the quality and quantity of the metabolites. Pharmacologic manipulation of the pathways of AA metabolism, or alteration of the effects of AA metabolites, can significantly improve tissue perfusion in a variety of clinical situations. (See Figure 1 for a schematic summary of the pathways involved in arachidonic acid metabolites.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>3143831</pmid><doi>10.1055/s-2007-1006954</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of reconstructive microsurgery, 1988-10, Vol.4 (5), p.421-426 |
| issn | 0743-684X 1098-8947 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Arachidonic Acid Arachidonic Acids BASIC SCIENCE REVIEW Biological and medical sciences Burns - physiopathology Diet Humans Leukotrienes - physiology Medical sciences Microcirculation Orthopedic surgery Prostaglandins - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery, Plastic Surgical Flaps Thromboxanes - physiology |
| title | Arachidonic Acid Metabolites: Basic Concepts Relevant to Plastic Surgery |
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