Priming and boosting of the rabbit intestinal immune system with live and killed, smooth and rough Vibrio cholerae cells

Cholera disease can be induced in the rabbit by ligation of the cecum (C) followed by duodenal inoculation (Dl) of virulent Vibrio cholerae organisms (DIC model). When the cecum is not ligated, Dl does not induce disease. In contrast, the animals are primed which becomes apparent upon challenge with...

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