Disregulated expression of CD43 (leukosialin, sialophorin) in the B cell lineage leads to immunodeficiency

Leukosialin (CD43 or sialophorin) is a cell surface sialoglycoprotein implicated in cell adhesion and proliferation whose tightly regulated expression in B lymphocytes is likely important for their normal development and/or function. To examine the physiologic role of mouse CD43 (mCD43) in vivo, we...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-12, Vol.157 (11), p.4876-4884
Hauptverfasser:	Ostberg, JR, Dragone, LL, Driskell, T, Moynihan, JA, Phipps, R, Barth, RK, Frelinger, JG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Antigens, CD - genetics Antigens, CD - metabolism B-Lymphocytes - immunology B-Lymphocytes - pathology Cell Adhesion - genetics Cell Adhesion - immunology Cell Differentiation Gene Expression Hemocyanins - immunology Immunoglobulin M - biosynthesis Immunoglobulins - genetics Immunoglobulins - metabolism Immunologic Deficiency Syndromes - etiology Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - immunology Leukosialin Lipopolysaccharides - pharmacology Lymphocyte Activation Lymphocyte Cooperation - genetics Lymphocyte Cooperation - immunology Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Models, Biological Ovalbumin - immunology Sialoglycoproteins - genetics Sialoglycoproteins - immunology Sialoglycoproteins - metabolism Spleen - immunology Spleen - pathology
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