Prolactin and MA-10 Leydig cell steroidogenesis: biphasic effects of prolactin and signal transduction

The present investigation was designed to study the direct role of PRL on testicular Leydig cell steroidogenesis, using the MA-10 murine Leydig tumor cell line as a model system. We have previously reported on the presence of specific PRL binding sites in those cells, and we now demonstrate the func...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1996-12, Vol.137 (12), p.5509-5518
Hauptverfasser:	Weiss-Messer, E, Ber, R, Barkey, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase ADP-ribosylation Animals Binding sites Biological effects Calcitonin - pharmacology Cattle Cell differentiation Cell Division - drug effects Cell membranes Cell proliferation Cholera Cholera toxin Chorionic Gonadotropin - metabolism Chorionic Gonadotropin - pharmacology Dose-Response Relationship, Drug Exposure GTP-Binding Proteins - physiology Humans Leydig cells Leydig Cells - drug effects Leydig Cells - metabolism Male Mice Pertussis Pertussis toxin Progesterone Progesterone - secretion Prolactin Prolactin - pharmacology Proteins Receptor mechanisms Receptors Secretion Sheep Signal Transduction Steroidogenesis Steroids - biosynthesis Stimulation Time Factors Toxins Tumor Cells, Cultured Waterborne diseases
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