Albumin kinetics in edematous and nonedematous protein-energy malnourished children
The kinetic changes responsible for decreased plasma albumin and the relation between plasma albumin and the edema of protein-energy malnutrition (PEM) were investigated by measuring the plasma concentration, fractional (FSR) and intravascular absolute (ASR) synthesis rates of albumin in seven edema...
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| Veröffentlicht in: | The American journal of clinical nutrition 1996-12, Vol.64 (6), p.952-959 |
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| creator | Morlese, JF Forrester, T Badaloo, A Del Rosario, M Frazer, M Jahoor, F |
| description | The kinetic changes responsible for decreased plasma albumin and the relation between plasma albumin and the edema of protein-energy malnutrition (PEM) were investigated by measuring the plasma concentration, fractional (FSR) and intravascular absolute (ASR) synthesis rates of albumin in seven edematous and seven nonedematous children with PEM by using constant intragastric infusions of [2H3]leucine. Studies were done 2 d postadmission (study 1), 8 d postadmission (study 2), and at recovery (study 3). In study 1 there were no significant differences in plasma albumin concentrations in nonedematous and edematous children. In both groups, albumin concentrations but not FSRs were lower in studies 1 and 2 than in study 3. The ASR was lower only in edematous patients. These results suggest that repletion of the albumin pool of children with PEM is not mediated by changes in the FSR, and the edema of malnutrition is not solely due to hypoalbuminemia. |
| doi_str_mv | 10.1093/ajcn/64.6.952 |
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Studies were done 2 d postadmission (study 1), 8 d postadmission (study 2), and at recovery (study 3). In study 1 there were no significant differences in plasma albumin concentrations in nonedematous and edematous children. In both groups, albumin concentrations but not FSRs were lower in studies 1 and 2 than in study 3. The ASR was lower only in edematous patients. 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Studies were done 2 d postadmission (study 1), 8 d postadmission (study 2), and at recovery (study 3). In study 1 there were no significant differences in plasma albumin concentrations in nonedematous and edematous children. In both groups, albumin concentrations but not FSRs were lower in studies 1 and 2 than in study 3. The ASR was lower only in edematous patients. These results suggest that repletion of the albumin pool of children with PEM is not mediated by changes in the FSR, and the edema of malnutrition is not solely due to hypoalbuminemia.</description><subject>Albumins - pharmacokinetics</subject><subject>Apolipoprotein B-100</subject><subject>Apolipoproteins B - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Children & youth</subject><subject>Edema - metabolism</subject><subject>Edema - physiopathology</subject><subject>Female</subject><subject>Hemostasis - physiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Kinetics</subject><subject>Leucine - metabolism</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Plasma</subject><subject>Protein-Energy Malnutrition - metabolism</subject><subject>Protein-Energy Malnutrition - physiopathology</subject><subject>Proteins</subject><subject>Serum Albumin - metabolism</subject><subject>Time Factors</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQQEVoSDdpjj0WTCm5eSONvqxjCP2CQA9tz0KWxo22tpxKdiD_Plp2SaHQk4TmaXg8Qt4yumXU8Gu38-laia3aGgknZMMM71oOVL8iG0optIYp-Zqcl7KjlIHo1Bk564wAAbAh32_Gfp1ian7HhEv0pal3DDi5ZV5L41Jo0pz-PjzkecGYWkyYfz01kxvTvOZY7jE0_j6OIWN6Q04HNxa8PJ4X5Oenjz9uv7R33z5_vb25a73gbGkd9cCERqYD9F2HpodAg2R9L8AL54Li0qPRBvhAQTglpBb1q6I4DIZzfkGuDnur1J8Vy2KnWDyOo0tYXa3upGZSigq-_wfcVelU3SxwZgCA6Qq1B8jnuZSMg33IcXL5yTJq96XtvrRVwipbS1f-3XHp2k8YXuhj2jr_cJy74t04ZJd8LC8YSMY7usf0AcNa6jFitsVHTB5DzOgXG-b4H4FnZmOZyA</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Morlese, JF</creator><creator>Forrester, T</creator><creator>Badaloo, A</creator><creator>Del Rosario, M</creator><creator>Frazer, M</creator><creator>Jahoor, F</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Albumin kinetics in edematous and nonedematous protein-energy malnourished children</title><author>Morlese, JF ; 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| ispartof | The American journal of clinical nutrition, 1996-12, Vol.64 (6), p.952-959 |
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| subjects | Albumins - pharmacokinetics Apolipoprotein B-100 Apolipoproteins B - metabolism Biological and medical sciences Body Weight - physiology Children & youth Edema - metabolism Edema - physiopathology Female Hemostasis - physiology Humans Infant Kinetics Leucine - metabolism Male Malnutrition Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Plasma Protein-Energy Malnutrition - metabolism Protein-Energy Malnutrition - physiopathology Proteins Serum Albumin - metabolism Time Factors |
| title | Albumin kinetics in edematous and nonedematous protein-energy malnourished children |
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