The Epimorphin Gene Is Highly Conserved among Humans, Mice, and Rats and Maps to Human Chromosome 7, Mouse Chromosome 5, and Rat Chromosome 12
A genomic DNA fragment containing the rat epimorphin gene sequence was cloned from a rat DNA cosmid library using a mouse epimorphin cDNA probe. Within the cosmid insert, nine epimorphin exons were identified and sequenced. The predicted amino acid sequence of the rat epimorphin protein exhibited 96...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1996-11, Vol.37 (3), p.386-389 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Zha, Hongbin Remmers, Elaine F. Szpirer, Claude Szpirer, Josiane Zhang, Heying Kozak, Christine A. Wilder, Ronald L. |
| description | A genomic DNA fragment containing the rat epimorphin gene sequence was cloned from a rat DNA cosmid library using a mouse epimorphin cDNA probe. Within the cosmid insert, nine epimorphin exons were identified and sequenced. The predicted amino acid sequence of the rat epimorphin protein exhibited 96 and 86% identity with the mouse and human epimorphin proteins, respectively. Consistent with the developmentally related expression pattern of the mouse epimorphin gene, transcripts of the rat epimorphin gene were detected in 17-day postfertilization rat embryos. The gene, designatedEpim,was assigned to rat chromosome 12 by somatic cell hybrid analysis and localized to 12q16 by fluorescencein situhybridization. The mouse and human homologs of this gene were localized on mouse chromosome 5 and human chromosome 7 by linkage analysis and chromosomalin situhybridization, respectively. |
| doi_str_mv | 10.1006/geno.1996.0574 |
| format | Article |
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Within the cosmid insert, nine epimorphin exons were identified and sequenced. The predicted amino acid sequence of the rat epimorphin protein exhibited 96 and 86% identity with the mouse and human epimorphin proteins, respectively. Consistent with the developmentally related expression pattern of the mouse epimorphin gene, transcripts of the rat epimorphin gene were detected in 17-day postfertilization rat embryos. The gene, designatedEpim,was assigned to rat chromosome 12 by somatic cell hybrid analysis and localized to 12q16 by fluorescencein situhybridization. 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Within the cosmid insert, nine epimorphin exons were identified and sequenced. The predicted amino acid sequence of the rat epimorphin protein exhibited 96 and 86% identity with the mouse and human epimorphin proteins, respectively. Consistent with the developmentally related expression pattern of the mouse epimorphin gene, transcripts of the rat epimorphin gene were detected in 17-day postfertilization rat embryos. The gene, designatedEpim,was assigned to rat chromosome 12 by somatic cell hybrid analysis and localized to 12q16 by fluorescencein situhybridization. The mouse and human homologs of this gene were localized on mouse chromosome 5 and human chromosome 7 by linkage analysis and chromosomalin situhybridization, respectively.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, Pair 7 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Crosses, Genetic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Mice - genetics</subject><subject>Molecular Sequence Data</subject><subject>Muridae - genetics</subject><subject>Rats - genetics</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><subject>Syntaxin 1</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9r3DAQxUVpSbdpr70VdCg9xVvJkvXnWJY0G0golPQsZGm8q2JLruQN5EvkM9fuLksuPc0w83vDYx5CHylZU0LE1x3EtKZaizVpJH-FVpQoXSnBxWu0IkqpSjacvUXvSvlNCNFM1RfoQs2VN_UKPT_sAV-PYUh53IeIbyACvi14G3b7_glvUiyQH8FjO6S4w9vDYGO5wvfBwRW20eOfdir_mns7FjylI4I3-5yGVNIAWM54OhR4OWvO4pdTWr9HbzrbF_hwqpfo1_frh822uvtxc7v5dlc5TtRUgXSeegKd0MLKzitHtOgolZ2oQXPGtAftJbfUEdaKtmsZt8A959pby1p2ib4c7445_TlAmcwQioO-txFmr0aqRlJS0xlcH0GXUykZOjPmMNj8ZCgxSwBmCcAsAZglgFnw6XT50A7gz_jp4_P-82lvi7N9l210oZyxmuuayQVTRwzmLzwGyKa4ANGBDxncZHwK_3PwF79AoU0</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Zha, Hongbin</creator><creator>Remmers, Elaine F.</creator><creator>Szpirer, Claude</creator><creator>Szpirer, Josiane</creator><creator>Zhang, Heying</creator><creator>Kozak, Christine A.</creator><creator>Wilder, Ronald L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>The Epimorphin Gene Is Highly Conserved among Humans, Mice, and Rats and Maps to Human Chromosome 7, Mouse Chromosome 5, and Rat Chromosome 12</title><author>Zha, Hongbin ; Remmers, Elaine F. ; Szpirer, Claude ; Szpirer, Josiane ; Zhang, Heying ; Kozak, Christine A. ; Wilder, Ronald L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-e7cd1d0ef696a7fd8c096f117f62e94339de9d74a1c03b6bfb34ae4d449daa3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, Pair 7 - genetics</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Crosses, Genetic</topic><topic>Fundamental and applied biological sciences. 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Within the cosmid insert, nine epimorphin exons were identified and sequenced. The predicted amino acid sequence of the rat epimorphin protein exhibited 96 and 86% identity with the mouse and human epimorphin proteins, respectively. Consistent with the developmentally related expression pattern of the mouse epimorphin gene, transcripts of the rat epimorphin gene were detected in 17-day postfertilization rat embryos. The gene, designatedEpim,was assigned to rat chromosome 12 by somatic cell hybrid analysis and localized to 12q16 by fluorescencein situhybridization. The mouse and human homologs of this gene were localized on mouse chromosome 5 and human chromosome 7 by linkage analysis and chromosomalin situhybridization, respectively.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8938452</pmid><doi>10.1006/geno.1996.0574</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genomics (San Diego, Calif.), 1996-11, Vol.37 (3), p.386-389 |
| issn | 0888-7543 1089-8646 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Chromosomes, Human, Pair 7 - genetics Classical genetics, quantitative genetics, hybrids Crosses, Genetic Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human Humans In Situ Hybridization, Fluorescence Membrane Glycoproteins - genetics Mice - genetics Molecular Sequence Data Muridae - genetics Rats - genetics Sequence Alignment Sequence Homology, Amino Acid Syntaxin 1 |
| title | The Epimorphin Gene Is Highly Conserved among Humans, Mice, and Rats and Maps to Human Chromosome 7, Mouse Chromosome 5, and Rat Chromosome 12 |
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