Agents that target telomerase and telomeres
Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be exp...
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| Veröffentlicht in: | Current opinion in biotechnology 1996-12, Vol.7 (6), p.583-591 |
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| container_issue | 6 |
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| container_title | Current opinion in biotechnology |
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| creator | Raymond, Eric Sun, Daekyu Chen, Shih-Fong Windle, Bradford Von Hoff, Daniel D |
| description | Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be expressed in tumor cells, which concurrently have short telomeres, and not in most somatic cells, which usually have long telomeres, telomerase and telomere structures have been recently proposed as attractive targets for the discovery of new anticancer agents. The most exciting current strategies are aimed at specifically designing new drugs that target telomerase or telomeres and new models have been formulated to study the biological effects of inhibitors of telomerase and telomeres both
in vitro and
in vivo. |
| doi_str_mv | 10.1016/S0958-1669(96)80068-1 |
| format | Article |
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in vitro and
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in vitro and
in vivo.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Drug Design</subject><subject>Drug Resistance, Neoplasm</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Mice</subject><subject>Models, Molecular</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - genetics</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleoproteins - drug effects</subject><subject>Reverse Transcriptase Inhibitors - chemistry</subject><subject>Reverse Transcriptase Inhibitors - pharmacology</subject><subject>Telomerase - antagonists & inhibitors</subject><subject>Telomerase - genetics</subject><subject>Telomerase - metabolism</subject><subject>Telomere - chemistry</subject><subject>Telomere - drug effects</subject><subject>Telomere - genetics</subject><issn>0958-1669</issn><issn>1879-0429</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLAzEQhYMotVZ_QqFPoshqsptkM09Sijco-KA-h2wyqSt7qclW8N-7vdjXPh2GOTNn5iNkzOgto0zevVEQKmFSwhXIa0Wp7KsjMmQqh4TyFI7JcG85JWcxflFKRZbTARkoyEDydEhupgtsujjpPk036UxYYC9YtTUGE3FiGvdfYjwnJ95UES92OiIfjw_vs-dk_vr0MpvOE8vTvEsQhaOQ8dSC8SCLwjhBaeGcEYYbrzjlhc8kE94DB4uOW8l9LoxBVLll2YhcbvcuQ_u9wtjpuowWq8o02K6izpWQioM4aGQChBSQ9UaxNdrQxhjQ62UoaxN-NaN6TVNvaOo1Kg1Sb2jq9SXjXcCqqNHtp3b4-v79to89jp8Sg462xKb_qQxoO-3a8kDCH7oKhHU</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Raymond, Eric</creator><creator>Sun, Daekyu</creator><creator>Chen, Shih-Fong</creator><creator>Windle, Bradford</creator><creator>Von Hoff, Daniel D</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Agents that target telomerase and telomeres</title><author>Raymond, Eric ; Sun, Daekyu ; Chen, Shih-Fong ; Windle, Bradford ; Von Hoff, Daniel D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-ee5d09342c9af96bbad500bdda5a4af8404bf3615ff949ced4c64f75aaee87c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Drug Design</topic><topic>Drug Resistance, Neoplasm</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Mice</topic><topic>Models, Molecular</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - genetics</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleoproteins - drug effects</topic><topic>Reverse Transcriptase Inhibitors - chemistry</topic><topic>Reverse Transcriptase Inhibitors - pharmacology</topic><topic>Telomerase - antagonists & inhibitors</topic><topic>Telomerase - genetics</topic><topic>Telomerase - metabolism</topic><topic>Telomere - chemistry</topic><topic>Telomere - drug effects</topic><topic>Telomere - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raymond, Eric</creatorcontrib><creatorcontrib>Sun, Daekyu</creatorcontrib><creatorcontrib>Chen, Shih-Fong</creatorcontrib><creatorcontrib>Windle, Bradford</creatorcontrib><creatorcontrib>Von Hoff, Daniel D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raymond, Eric</au><au>Sun, Daekyu</au><au>Chen, Shih-Fong</au><au>Windle, Bradford</au><au>Von Hoff, Daniel D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Agents that target telomerase and telomeres</atitle><jtitle>Current opinion in biotechnology</jtitle><addtitle>Curr Opin Biotechnol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>7</volume><issue>6</issue><spage>583</spage><epage>591</epage><pages>583-591</pages><issn>0958-1669</issn><eissn>1879-0429</eissn><abstract>Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be expressed in tumor cells, which concurrently have short telomeres, and not in most somatic cells, which usually have long telomeres, telomerase and telomere structures have been recently proposed as attractive targets for the discovery of new anticancer agents. The most exciting current strategies are aimed at specifically designing new drugs that target telomerase or telomeres and new models have been formulated to study the biological effects of inhibitors of telomerase and telomeres both
in vitro and
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| ispartof | Current opinion in biotechnology, 1996-12, Vol.7 (6), p.583-591 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Drug Design Drug Resistance, Neoplasm Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Mice Models, Molecular Neoplasms - drug therapy Neoplasms - genetics Nucleic Acid Conformation Nucleoproteins - drug effects Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - pharmacology Telomerase - antagonists & inhibitors Telomerase - genetics Telomerase - metabolism Telomere - chemistry Telomere - drug effects Telomere - genetics |
| title | Agents that target telomerase and telomeres |
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