The Immunogenicity of Three Haemophilus influenzae Type B Conjugate Vaccines after a Primary Vaccination Series in Philippine Infants
Serum antibody responses to three Haemophilus influenzae type b (Hib) capsular polysaccharide-protein conjugate vaccine (PRP-OMP, PRP-T, and HbOC) were evaluated in 174 Philippine infants after a primary vaccination series. Children were randomized to receive one of the Hib vaccines (Hib groups) or...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 1996-11, Vol.55 (5), p.516-520 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Capeding, Maria Rosario Z Nohynek, Hanna Pascual, Luz G Kayhty, Helena Sombrero, Lydia T Eskola, Juhani Ruutu, Petri |
| description | Serum antibody responses to three Haemophilus influenzae type b (Hib) capsular polysaccharide-protein conjugate vaccine (PRP-OMP, PRP-T, and HbOC) were evaluated in 174 Philippine infants after a primary vaccination series. Children were randomized to receive one of the Hib vaccines (Hib groups) or into a control group. Vaccination was carried out at six, 10 and 14 weeks of age based on the local Expanded Program of Immunization schedule. Sera were collected at six weeks of age for the Hib groups and one month after the third dose for all subjects. Anti-Hib concentrations were determined by the Farr-type radioimmunoassay. There were no significant differences (P = 0.3626) in the prevaccination anti-Hib geometric mean concentration (GMC) among the three Hib groups. Differences in the GMC after the primary series of three doses were significant (P < 0.0001); GMC was highest for PRP-T (6.62 micrograms/ml), followed by HbOC (1.9 micrograms/ml), then PRP-OMP (1.06 micrograms/ml), and lowest for the control group (0.11 microgram/ml). We conclude that all three Hib conjugate vaccines (PRP-T, HbOC, and PRP-OMP) were immunogenic after three primary doses among Philippine infants. |
| doi_str_mv | 10.4269/ajtmh.1996.55.516 |
| format | Article |
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Children were randomized to receive one of the Hib vaccines (Hib groups) or into a control group. Vaccination was carried out at six, 10 and 14 weeks of age based on the local Expanded Program of Immunization schedule. Sera were collected at six weeks of age for the Hib groups and one month after the third dose for all subjects. Anti-Hib concentrations were determined by the Farr-type radioimmunoassay. There were no significant differences (P = 0.3626) in the prevaccination anti-Hib geometric mean concentration (GMC) among the three Hib groups. Differences in the GMC after the primary series of three doses were significant (P < 0.0001); GMC was highest for PRP-T (6.62 micrograms/ml), followed by HbOC (1.9 micrograms/ml), then PRP-OMP (1.06 micrograms/ml), and lowest for the control group (0.11 microgram/ml). 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Nohynek, Hanna ; Pascual, Luz G ; Kayhty, Helena ; Sombrero, Lydia T ; Eskola, Juhani ; Ruutu, Petri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2116af3c0dd33bed08c6e1e36d649dd66e5c4fb9501fca554a6976ad5fef94833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Antibodies, Bacterial - analysis</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the respiratory system</topic><topic>Bacterial Outer Membrane Proteins - adverse effects</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Bacterial Proteins - adverse effects</topic><topic>Bacterial Proteins - immunology</topic><topic>Biological and medical sciences</topic><topic>Haemophilus Infections - immunology</topic><topic>Haemophilus Infections - prevention & control</topic><topic>Haemophilus influenzae</topic><topic>Haemophilus influenzae - immunology</topic><topic>Haemophilus Vaccines - administration & dosage</topic><topic>Haemophilus Vaccines - adverse effects</topic><topic>Haemophilus Vaccines - immunology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Polysaccharides, Bacterial - adverse effects</topic><topic>Polysaccharides, Bacterial - immunology</topic><topic>Tetanus Toxoid - adverse effects</topic><topic>Tetanus Toxoid - immunology</topic><topic>Tropical medicine</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capeding, Maria Rosario Z</creatorcontrib><creatorcontrib>Nohynek, Hanna</creatorcontrib><creatorcontrib>Pascual, Luz G</creatorcontrib><creatorcontrib>Kayhty, Helena</creatorcontrib><creatorcontrib>Sombrero, Lydia T</creatorcontrib><creatorcontrib>Eskola, Juhani</creatorcontrib><creatorcontrib>Ruutu, Petri</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capeding, Maria Rosario Z</au><au>Nohynek, Hanna</au><au>Pascual, Luz G</au><au>Kayhty, Helena</au><au>Sombrero, Lydia T</au><au>Eskola, Juhani</au><au>Ruutu, Petri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Immunogenicity of Three Haemophilus influenzae Type B Conjugate Vaccines after a Primary Vaccination Series in Philippine Infants</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>55</volume><issue>5</issue><spage>516</spage><epage>520</epage><pages>516-520</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Serum antibody responses to three Haemophilus influenzae type b (Hib) capsular polysaccharide-protein conjugate vaccine (PRP-OMP, PRP-T, and HbOC) were evaluated in 174 Philippine infants after a primary vaccination series. Children were randomized to receive one of the Hib vaccines (Hib groups) or into a control group. Vaccination was carried out at six, 10 and 14 weeks of age based on the local Expanded Program of Immunization schedule. Sera were collected at six weeks of age for the Hib groups and one month after the third dose for all subjects. Anti-Hib concentrations were determined by the Farr-type radioimmunoassay. There were no significant differences (P = 0.3626) in the prevaccination anti-Hib geometric mean concentration (GMC) among the three Hib groups. Differences in the GMC after the primary series of three doses were significant (P < 0.0001); GMC was highest for PRP-T (6.62 micrograms/ml), followed by HbOC (1.9 micrograms/ml), then PRP-OMP (1.06 micrograms/ml), and lowest for the control group (0.11 microgram/ml). We conclude that all three Hib conjugate vaccines (PRP-T, HbOC, and PRP-OMP) were immunogenic after three primary doses among Philippine infants.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>8940983</pmid><doi>10.4269/ajtmh.1996.55.516</doi><tpages>5</tpages></addata></record> |
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| subjects | Antibodies, Bacterial - analysis Bacterial diseases Bacterial diseases of the respiratory system Bacterial Outer Membrane Proteins - adverse effects Bacterial Outer Membrane Proteins - immunology Bacterial Proteins - adverse effects Bacterial Proteins - immunology Biological and medical sciences Haemophilus Infections - immunology Haemophilus Infections - prevention & control Haemophilus influenzae Haemophilus influenzae - immunology Haemophilus Vaccines - administration & dosage Haemophilus Vaccines - adverse effects Haemophilus Vaccines - immunology Human bacterial diseases Humans Infant Infectious diseases Medical sciences Polysaccharides, Bacterial - adverse effects Polysaccharides, Bacterial - immunology Tetanus Toxoid - adverse effects Tetanus Toxoid - immunology Tropical medicine Vaccination |
| title | The Immunogenicity of Three Haemophilus influenzae Type B Conjugate Vaccines after a Primary Vaccination Series in Philippine Infants |
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