Impaired Neutrophil Function in Patients With AIDS or AIDS-Related Complex: A Comprehensive Evaluation
We measured the neutrophil function of 6 patients with AIDS and Kaposi's sarcoma (KS); 22 patients with AIDS-related complex (ARC); and 28 healthy, heterosexual controls. .Neutrophils from patients with ARC showed significantly less chemotaxis (P ⩽ .025) than did those from patients with AIDS a...
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| Veröffentlicht in: | The Journal of infectious diseases 1988-12, Vol.158 (6), p.1268-1276 |
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| container_title | The Journal of infectious diseases |
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| creator | Ellis, Mark Gupta, Sudhir Galant, Stanley Hakim, Said VandeVen, Carmella Toy, Cindi Cairo, Mitchell S. |
| description | We measured the neutrophil function of 6 patients with AIDS and Kaposi's sarcoma (KS); 22 patients with AIDS-related complex (ARC); and 28 healthy, heterosexual controls. .Neutrophils from patients with ARC showed significantly less chemotaxis (P ⩽ .025) than did those from patients with AIDS and KS or from controls. Serum from patients with AIDS and KS or with ARC significantly (P ⩽ .05) inhibited chemotaxis of neutrophils from controls; heat treatment of the serum abolished this inhibitory effect. Bacterial killing by neutrophils from patients with AIDS and KS or with ARC was also significantly (P ⩽ .05) less than for neutrophils from controls, as was neutrophil phagocytosis binding of Candida albicans (P ⩽ .05). Expression ofOKMI antigen was increased in the patients studied. Enzyme degranulation, adherence, and aggregation werealso examined. The defects found in neutrophil function are selective and may be important in the increased susceptibility of patients with human immunodeficiency virus infection to bacterial and fungal infections. |
| doi_str_mv | 10.1093/infdis/158.6.1268 |
| format | Article |
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Serum from patients with AIDS and KS or with ARC significantly (P ⩽ .05) inhibited chemotaxis of neutrophils from controls; heat treatment of the serum abolished this inhibitory effect. Bacterial killing by neutrophils from patients with AIDS and KS or with ARC was also significantly (P ⩽ .05) less than for neutrophils from controls, as was neutrophil phagocytosis binding of Candida albicans (P ⩽ .05). Expression ofOKMI antigen was increased in the patients studied. Enzyme degranulation, adherence, and aggregation werealso examined. The defects found in neutrophil function are selective and may be important in the increased susceptibility of patients with human immunodeficiency virus infection to bacterial and fungal infections.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/158.6.1268</identifier><identifier>PMID: 3058816</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University Chicago Press</publisher><subject>Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - immunology ; Adult ; Aggregation ; AIDS ; AIDS related complex ; AIDS-Related Complex - blood ; AIDS-Related Complex - immunology ; AIDS/HIV ; Antibodies ; Antigens, Surface - biosynthesis ; Bacteria ; Biological and medical sciences ; Blood Bactericidal Activity ; Candida albicans - immunology ; Cell Adhesion ; Cell Aggregation ; Chemotaxis ; Chemotaxis, Leukocyte ; Flow Cytometry ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infections ; Leukocyte Count ; Male ; Medical sciences ; Neutropenia ; Neutrophils ; Neutrophils - immunology ; Original Articles ; Phagocytosis ; Staphylococcus aureus - immunology</subject><ispartof>The Journal of infectious diseases, 1988-12, Vol.158 (6), p.1268-1276</ispartof><rights>Copyright 1988 The University of Chicago</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-af1db1c47f1b3d602141c42a02e61a1ab33cc39e8b702693cd3b7e6ae08de6d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30137048$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30137048$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7070810$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3058816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellis, Mark</creatorcontrib><creatorcontrib>Gupta, Sudhir</creatorcontrib><creatorcontrib>Galant, Stanley</creatorcontrib><creatorcontrib>Hakim, Said</creatorcontrib><creatorcontrib>VandeVen, Carmella</creatorcontrib><creatorcontrib>Toy, Cindi</creatorcontrib><creatorcontrib>Cairo, Mitchell S.</creatorcontrib><title>Impaired Neutrophil Function in Patients With AIDS or AIDS-Related Complex: A Comprehensive Evaluation</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>We measured the neutrophil function of 6 patients with AIDS and Kaposi's sarcoma (KS); 22 patients with AIDS-related complex (ARC); and 28 healthy, heterosexual controls. .Neutrophils from patients with ARC showed significantly less chemotaxis (P ⩽ .025) than did those from patients with AIDS and KS or from controls. Serum from patients with AIDS and KS or with ARC significantly (P ⩽ .05) inhibited chemotaxis of neutrophils from controls; heat treatment of the serum abolished this inhibitory effect. Bacterial killing by neutrophils from patients with AIDS and KS or with ARC was also significantly (P ⩽ .05) less than for neutrophils from controls, as was neutrophil phagocytosis binding of Candida albicans (P ⩽ .05). Expression ofOKMI antigen was increased in the patients studied. Enzyme degranulation, adherence, and aggregation werealso examined. The defects found in neutrophil function are selective and may be important in the increased susceptibility of patients with human immunodeficiency virus infection to bacterial and fungal infections.</description><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Adult</subject><subject>Aggregation</subject><subject>AIDS</subject><subject>AIDS related complex</subject><subject>AIDS-Related Complex - blood</subject><subject>AIDS-Related Complex - immunology</subject><subject>AIDS/HIV</subject><subject>Antibodies</subject><subject>Antigens, Surface - biosynthesis</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Blood Bactericidal Activity</subject><subject>Candida albicans - immunology</subject><subject>Cell Adhesion</subject><subject>Cell Aggregation</subject><subject>Chemotaxis</subject><subject>Chemotaxis, Leukocyte</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infections</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neutropenia</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Original Articles</subject><subject>Phagocytosis</subject><subject>Staphylococcus aureus - immunology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhA3BA8gFxy9YTJ7bDbbW0dMUKEF3RiovlOBOtS_7Vdqr22zfbXQo3TjOj997Pkh8hb4HNgRX8xHV15cIJ5Gou5pAK9YzMIOcyEQL4czJjLE0TUEXxkrwK4ZoxlnEhj8gRZ7lSIGakXrWDcR4r-hXH6Pth6xp6NnY2ur6jrqPfTXTYxUAvXdzSxerTBe3940x-YGPilFz27dDg3Ue6eFw9brEL7hbp6a1pRrMjvSYvatMEfHOYx2RzdrpZnifrb59Xy8U6sRmImJgaqhJsJmsoeSVYCtl0pYalKMCAKTm3lheoSslSUXBb8VKiMMhUhaLix-TDHjv4_mbEEHXrgsWmMR32Y9BS5UKCEP81Qg4pMMEnI-yN1vcheKz14F1r_L0Gpncd6H0HU0JpoXcdTJl3B_hYtlg9JQ6fPunvD7oJ1jS1N52dCH9skkmmgP3FXIfY-38owCXLds8ke92FiHdPuvG_tZBc5vr86pe--Pnlcr25YnrJHwCZsqk_</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>Ellis, Mark</creator><creator>Gupta, Sudhir</creator><creator>Galant, Stanley</creator><creator>Hakim, Said</creator><creator>VandeVen, Carmella</creator><creator>Toy, Cindi</creator><creator>Cairo, Mitchell S.</creator><general>The University Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Impaired Neutrophil Function in Patients With AIDS or AIDS-Related Complex: A Comprehensive Evaluation</title><author>Ellis, Mark ; Gupta, Sudhir ; Galant, Stanley ; Hakim, Said ; VandeVen, Carmella ; Toy, Cindi ; Cairo, Mitchell S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-af1db1c47f1b3d602141c42a02e61a1ab33cc39e8b702693cd3b7e6ae08de6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Adult</topic><topic>Aggregation</topic><topic>AIDS</topic><topic>AIDS related complex</topic><topic>AIDS-Related Complex - blood</topic><topic>AIDS-Related Complex - immunology</topic><topic>AIDS/HIV</topic><topic>Antibodies</topic><topic>Antigens, Surface - biosynthesis</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>Blood Bactericidal Activity</topic><topic>Candida albicans - immunology</topic><topic>Cell Adhesion</topic><topic>Cell Aggregation</topic><topic>Chemotaxis</topic><topic>Chemotaxis, Leukocyte</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infections</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neutropenia</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Original Articles</topic><topic>Phagocytosis</topic><topic>Staphylococcus aureus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellis, Mark</creatorcontrib><creatorcontrib>Gupta, Sudhir</creatorcontrib><creatorcontrib>Galant, Stanley</creatorcontrib><creatorcontrib>Hakim, Said</creatorcontrib><creatorcontrib>VandeVen, Carmella</creatorcontrib><creatorcontrib>Toy, Cindi</creatorcontrib><creatorcontrib>Cairo, Mitchell S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellis, Mark</au><au>Gupta, Sudhir</au><au>Galant, Stanley</au><au>Hakim, Said</au><au>VandeVen, Carmella</au><au>Toy, Cindi</au><au>Cairo, Mitchell S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Neutrophil Function in Patients With AIDS or AIDS-Related Complex: A Comprehensive Evaluation</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>158</volume><issue>6</issue><spage>1268</spage><epage>1276</epage><pages>1268-1276</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We measured the neutrophil function of 6 patients with AIDS and Kaposi's sarcoma (KS); 22 patients with AIDS-related complex (ARC); and 28 healthy, heterosexual controls. .Neutrophils from patients with ARC showed significantly less chemotaxis (P ⩽ .025) than did those from patients with AIDS and KS or from controls. Serum from patients with AIDS and KS or with ARC significantly (P ⩽ .05) inhibited chemotaxis of neutrophils from controls; heat treatment of the serum abolished this inhibitory effect. Bacterial killing by neutrophils from patients with AIDS and KS or with ARC was also significantly (P ⩽ .05) less than for neutrophils from controls, as was neutrophil phagocytosis binding of Candida albicans (P ⩽ .05). Expression ofOKMI antigen was increased in the patients studied. Enzyme degranulation, adherence, and aggregation werealso examined. The defects found in neutrophil function are selective and may be important in the increased susceptibility of patients with human immunodeficiency virus infection to bacterial and fungal infections.</abstract><cop>Chicago, IL</cop><pub>The University Chicago Press</pub><pmid>3058816</pmid><doi>10.1093/infdis/158.6.1268</doi><tpages>9</tpages></addata></record> |
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| subjects | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - immunology Adult Aggregation AIDS AIDS related complex AIDS-Related Complex - blood AIDS-Related Complex - immunology AIDS/HIV Antibodies Antigens, Surface - biosynthesis Bacteria Biological and medical sciences Blood Bactericidal Activity Candida albicans - immunology Cell Adhesion Cell Aggregation Chemotaxis Chemotaxis, Leukocyte Flow Cytometry Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infections Leukocyte Count Male Medical sciences Neutropenia Neutrophils Neutrophils - immunology Original Articles Phagocytosis Staphylococcus aureus - immunology |
| title | Impaired Neutrophil Function in Patients With AIDS or AIDS-Related Complex: A Comprehensive Evaluation |
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