Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle

Lovastatin, simvastatin, and pravastatin are fairly strong inhibitors of sterol synthesis in human myoblasts in culture. Lovastatin and simvastatin have IC 50 values of 19 ± 6 nM and 4.0 ± 2.3 nM, respectively. Pravastatin is a weaker inhibitor of sterol synthesis (IC 50 value of 110 ± 38 nM). Throu...

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Veröffentlicht in:	Biochemical pharmacology 1996-11, Vol.52 (9), p.1387-1392
Hauptverfasser:	van Vliet, Arlène K., Nègre-Aminou, Pascale, van Thiel, G.Christa F., Bolhuis, Piet A., Cohen, Louis H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid - metabolism Adenosine Triphosphate - metabolism Anticholesteremic Agents - pharmacology Biological and medical sciences Cell Division - drug effects cell proliferation Cell Survival - drug effects Cells, Cultured DNA - biosynthesis Enzyme Inhibitors - pharmacology General and cellular metabolism. Vitamins HMG-CoA reductase inhibitors human myoblasts Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors lovastatin Lovastatin - analogs & derivatives Lovastatin - pharmacology Medical sciences Mitochondria - enzymology Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Oxidoreductases - metabolism Pharmacology. Drug treatments pravastatin Pravastatin - pharmacology Simvastatin sterol synthesis Sterols - biosynthesis
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