Long-term analysis of peritoneal plasminogen activator activity and adhesion formation after surgical trauma in the rat model
Recent literature has shown that a common pathway in postsurgical adhesion formation is a transient reduction in local plasminogen activator activity, shortly after peritoneal trauma. This deficit in fibrinolysis permits deposited fibrin to become organized into fibrous, permanent adhesions. Althoug...
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| Veröffentlicht in: | Fertility and sterility 1996-12, Vol.66 (6), p.1018-1022 |
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| container_title | Fertility and sterility |
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| creator | Bakkum, Erica A. Emeis, Jef J. Dalmeijer, Remco A.J. van Blitterswijk, Clemens A. Trimbos, J. Baptist Trimbos-Kemper, Trudy C.M. |
| description | Recent literature has shown that a common pathway in postsurgical adhesion formation is a transient reduction in local plasminogen activator activity, shortly after peritoneal trauma. This deficit in fibrinolysis permits deposited fibrin to become organized into fibrous, permanent adhesions. Although adhesion formation is a process that continues beyond the first postoperative days, long-term analysis of this theory has not been performed.
A standardized peritoneal adhesion model in the rat.
Long-term analysis of the peritoneal fibrinolytic activity (extraction technique) was related to the extent of postsurgical adhesion formation, up to 1year postoperatively.
Total and tissue plasminogen activator activity were significantly increased at days 3 and 8, and 1month postoperatively. A mean adhesion percentage of 75% per peritoneal defect was found to persist throughout all evaluation times, which was directly related to the increase of fibrinolysis.
In contrast to the classical concept that adhesion formation is related to a reduction in fibrinolysis, an impressive increase of the fibrinolysis was found to be associated with the persistence of adhesions. |
| doi_str_mv | 10.1016/S0015-0282(16)58700-7 |
| format | Article |
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A standardized peritoneal adhesion model in the rat.
Long-term analysis of the peritoneal fibrinolytic activity (extraction technique) was related to the extent of postsurgical adhesion formation, up to 1year postoperatively.
Total and tissue plasminogen activator activity were significantly increased at days 3 and 8, and 1month postoperatively. A mean adhesion percentage of 75% per peritoneal defect was found to persist throughout all evaluation times, which was directly related to the increase of fibrinolysis.
In contrast to the classical concept that adhesion formation is related to a reduction in fibrinolysis, an impressive increase of the fibrinolysis was found to be associated with the persistence of adhesions.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)58700-7</identifier><identifier>PMID: 8941072</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Female ; Fibrinolysis ; fibrinolytic activity ; Medical sciences ; Peritoneal Diseases - etiology ; peritoneal side wall model ; Peritoneum - metabolism ; Peritoneum - surgery ; Plasminogen Activators - metabolism ; Postoperative Complications ; Postoperative Period ; Postsurgical adhesions ; rat ; Rats ; Rats, Wistar ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; Time Factors ; Tissue Adhesions - etiology</subject><ispartof>Fertility and sterility, 1996-12, Vol.66 (6), p.1018-1022</ispartof><rights>1996 American Society for Reproductive Medicine</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-d8adf28dd04be271cc7bc39f693858ad333d38d79ab47f0b1e9a73394ce68a493</citedby><cites>FETCH-LOGICAL-c389t-d8adf28dd04be271cc7bc39f693858ad333d38d79ab47f0b1e9a73394ce68a493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028216587007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2502020$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8941072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakkum, Erica A.</creatorcontrib><creatorcontrib>Emeis, Jef J.</creatorcontrib><creatorcontrib>Dalmeijer, Remco A.J.</creatorcontrib><creatorcontrib>van Blitterswijk, Clemens A.</creatorcontrib><creatorcontrib>Trimbos, J. Baptist</creatorcontrib><creatorcontrib>Trimbos-Kemper, Trudy C.M.</creatorcontrib><title>Long-term analysis of peritoneal plasminogen activator activity and adhesion formation after surgical trauma in the rat model</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Recent literature has shown that a common pathway in postsurgical adhesion formation is a transient reduction in local plasminogen activator activity, shortly after peritoneal trauma. This deficit in fibrinolysis permits deposited fibrin to become organized into fibrous, permanent adhesions. Although adhesion formation is a process that continues beyond the first postoperative days, long-term analysis of this theory has not been performed.
A standardized peritoneal adhesion model in the rat.
Long-term analysis of the peritoneal fibrinolytic activity (extraction technique) was related to the extent of postsurgical adhesion formation, up to 1year postoperatively.
Total and tissue plasminogen activator activity were significantly increased at days 3 and 8, and 1month postoperatively. A mean adhesion percentage of 75% per peritoneal defect was found to persist throughout all evaluation times, which was directly related to the increase of fibrinolysis.
In contrast to the classical concept that adhesion formation is related to a reduction in fibrinolysis, an impressive increase of the fibrinolysis was found to be associated with the persistence of adhesions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fibrinolysis</subject><subject>fibrinolytic activity</subject><subject>Medical sciences</subject><subject>Peritoneal Diseases - etiology</subject><subject>peritoneal side wall model</subject><subject>Peritoneum - metabolism</subject><subject>Peritoneum - surgery</subject><subject>Plasminogen Activators - metabolism</subject><subject>Postoperative Complications</subject><subject>Postoperative Period</subject><subject>Postsurgical adhesions</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>Time Factors</subject><subject>Tissue Adhesions - etiology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMuKFDEUhoMoYzv6CANZiOiiNKlUKqmVDIM3aHChrsOp5FRPpCppk9RAL3x309NNbyWLnPBfTvgIueHsPWe8__CDMS4b1ur2Le_fSa0Ya9QTsuFS9o3spXhKNhfLc_Ii59-MsZ6r9opc6aHjTLUb8ncbw64pmBYKAeZD9pnGie4x-RIDwkz3M-TFh7jDQMEW_wAlptPky6GmHAV3j9nHQKeYFijHCabaSfOadt7WkpJgXYD6QMs90gSFLtHh_JI8m2DO-Op8X5Nfnz_9vPvabL9_-XZ3u22s0ENpnAY3tdo51o3YKm6tGq0Ypn4QWlZNCOGEdmqAsVMTGzkOoIQYOou9hm4Q1-TNqXef4p8VczGLzxbnGQLGNRulKzCuumqUJ6NNMeeEk9knv0A6GM7MEbt5xG6OTE19PWI3quZuzgvWcUF3SZ05V_31WYdceUwJgvX5Ymsla-upto8nG1YYDx6TydZjsOh8QluMi_4_H_kHGuChcg</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Bakkum, Erica A.</creator><creator>Emeis, Jef J.</creator><creator>Dalmeijer, Remco A.J.</creator><creator>van Blitterswijk, Clemens A.</creator><creator>Trimbos, J. 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Baptist ; Trimbos-Kemper, Trudy C.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d8adf28dd04be271cc7bc39f693858ad333d38d79ab47f0b1e9a73394ce68a493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fibrinolysis</topic><topic>fibrinolytic activity</topic><topic>Medical sciences</topic><topic>Peritoneal Diseases - etiology</topic><topic>peritoneal side wall model</topic><topic>Peritoneum - metabolism</topic><topic>Peritoneum - surgery</topic><topic>Plasminogen Activators - metabolism</topic><topic>Postoperative Complications</topic><topic>Postoperative Period</topic><topic>Postsurgical adhesions</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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A standardized peritoneal adhesion model in the rat.
Long-term analysis of the peritoneal fibrinolytic activity (extraction technique) was related to the extent of postsurgical adhesion formation, up to 1year postoperatively.
Total and tissue plasminogen activator activity were significantly increased at days 3 and 8, and 1month postoperatively. A mean adhesion percentage of 75% per peritoneal defect was found to persist throughout all evaluation times, which was directly related to the increase of fibrinolysis.
In contrast to the classical concept that adhesion formation is related to a reduction in fibrinolysis, an impressive increase of the fibrinolysis was found to be associated with the persistence of adhesions.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8941072</pmid><doi>10.1016/S0015-0282(16)58700-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | Fertility and sterility, 1996-12, Vol.66 (6), p.1018-1022 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Female Fibrinolysis fibrinolytic activity Medical sciences Peritoneal Diseases - etiology peritoneal side wall model Peritoneum - metabolism Peritoneum - surgery Plasminogen Activators - metabolism Postoperative Complications Postoperative Period Postsurgical adhesions rat Rats Rats, Wistar Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland Time Factors Tissue Adhesions - etiology |
| title | Long-term analysis of peritoneal plasminogen activator activity and adhesion formation after surgical trauma in the rat model |
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