Escherichia coli gene purR encoding a repressor protein for purine nucleotide synthesis. Cloning, nucleotide sequence, and interaction with the purF operator

The Escherichia coli gene purR, encoding a repressor protein, was cloned by complementation of a purR mutation. Gene purR on a multicopy plasmid repressed expression of purF and purF-lacZ and reduced the growth rate of host cells by limiting the rate of de novo purine nucleotide synthesis. The level...

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Veröffentlicht in:The Journal of biological chemistry 1988-12, Vol.263 (36), p.19653-19661
Hauptverfasser: Rolfes, R J, Zalkin, H
Format: Artikel
Sprache:eng
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