Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart
Although strict selection criteria are being used for the acceptance of human donor hearts for transplantation, problems with respect to functional recovery on reperfusion sometimes still occur. Therefore, evaluation of the viability of a human donor heart before implantation during heart transplant...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1996-12, Vol.94 (11), p.2831-2836 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2836 |
|---|---|
| container_issue | 11 |
| container_start_page | 2831 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 94 |
| creator | VAN DOBBENBURGH, J. O LAHPOR, J. R WOOLLEY, S. R DE JONGE, N KLÖPPING, C VAN ECHTELD, C. J. A |
| description | Although strict selection criteria are being used for the acceptance of human donor hearts for transplantation, problems with respect to functional recovery on reperfusion sometimes still occur. Therefore, evaluation of the viability of a human donor heart before implantation during heart transplantation may be of great value.
In the present study, the energy metabolism of 25 excised human donor hearts arrested with St Thomas' Hospital No. 2 cardioplegic solution was evaluated noninvasively by use of 31P magnetic resonance spectroscopy (MRS) before implantation and was correlated with myocardial function measured with thermodilution in heart transplant patients. No significant correlation was observed between the cardiac index of heart transplant patients during the first hours after transplantation and the phosphocreatine/ATP (r = .13, P = .54), inorganic phosphate/ATP (r = .26, P = .21), phosphomonoesters/ATP (r = .02, P = .92), or phosphocreatine/inorganic phosphate (r = .16, P = .44) ratio or the intracellular pH (r = .06, P = .78) at the time of reperfusion. However, 1 week after transplantation, a significant correlation was observed between the cardiac index and the phosphocreatine/ATP (r = .49, P = .01), phosphomonoesters/ATP (r = .45, P = .02), and phosphocreatine/inorganic phosphate (r = .40, P = .05) ratios at the time of reperfusion. In contrast, the inorganic phosphate/ATP (r = .10, P = .63) ratio and pH (r = .31, P = .13) at the time of reperfusion showed a poor correlation with the cardiac index 1 week after transplantation.
Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart. |
| doi_str_mv | 10.1161/01.CIR.94.11.2831 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78563910</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78563910</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-df06492e2ee0eacc9a8c70d0e5dbacd661431ad93c70a771912344e814e64f383</originalsourceid><addsrcrecordid>eNpdkU9r3DAQxUVoSbdpPkAPBVFCb95qJNmyjmVp_kCgUNqzmJXHrINtbSW5sP301WaXHHIant5vBvQeYx9BrAEa-CpgvXn4uba6yLVsFVywFdRSV7pW9g1bCSFsZZSU79j7lJ6KbJSpL9llazWAsCv273aZfR7CjCOP5MNfigeOfabId8uEM98RxsxzxDntR5wzHmE-pEKPmKnjOfC8Iz5Rxm0YB899mLvhmQr9s7U77EOZcSpmF-YQT0c_sLc9jomuz_OK_b79_mtzXz3-uHvYfHusvLI6V10vGm0lSSJB6L3F1hvRCaq7LfquaUArwM6q8orGgAWptKYWNDW6V626Yl9Od_cx_FkoZTcNydNYfkNhSc60daMsiAJ-fgU-hSWWZJKTIBstSuQFghPkY0gpUu_2cZgwHhwIdyzFCXClFGd1ke5YStn5dD68bCfqXjbOLRT_5uxj8jj2JWw_pBdM1iCMMeo_u0uWTA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>212640161</pqid></control><display><type>article</type><title>Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Journals@Ovid Complete</source><creator>VAN DOBBENBURGH, J. O ; LAHPOR, J. R ; WOOLLEY, S. R ; DE JONGE, N ; KLÖPPING, C ; VAN ECHTELD, C. J. A</creator><creatorcontrib>VAN DOBBENBURGH, J. O ; LAHPOR, J. R ; WOOLLEY, S. R ; DE JONGE, N ; KLÖPPING, C ; VAN ECHTELD, C. J. A</creatorcontrib><description>Although strict selection criteria are being used for the acceptance of human donor hearts for transplantation, problems with respect to functional recovery on reperfusion sometimes still occur. Therefore, evaluation of the viability of a human donor heart before implantation during heart transplantation may be of great value.
In the present study, the energy metabolism of 25 excised human donor hearts arrested with St Thomas' Hospital No. 2 cardioplegic solution was evaluated noninvasively by use of 31P magnetic resonance spectroscopy (MRS) before implantation and was correlated with myocardial function measured with thermodilution in heart transplant patients. No significant correlation was observed between the cardiac index of heart transplant patients during the first hours after transplantation and the phosphocreatine/ATP (r = .13, P = .54), inorganic phosphate/ATP (r = .26, P = .21), phosphomonoesters/ATP (r = .02, P = .92), or phosphocreatine/inorganic phosphate (r = .16, P = .44) ratio or the intracellular pH (r = .06, P = .78) at the time of reperfusion. However, 1 week after transplantation, a significant correlation was observed between the cardiac index and the phosphocreatine/ATP (r = .49, P = .01), phosphomonoesters/ATP (r = .45, P = .02), and phosphocreatine/inorganic phosphate (r = .40, P = .05) ratios at the time of reperfusion. In contrast, the inorganic phosphate/ATP (r = .10, P = .63) ratio and pH (r = .31, P = .13) at the time of reperfusion showed a poor correlation with the cardiac index 1 week after transplantation.
Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.94.11.2831</identifier><identifier>PMID: 8941109</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cardiac Output ; Cryopreservation ; Energy Metabolism ; Female ; Heart - physiopathology ; Heart Transplantation ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Reperfusion ; Myocardium - metabolism ; Phosphates - metabolism ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Time Factors</subject><ispartof>Circulation (New York, N.Y.), 1996-12, Vol.94 (11), p.2831-2836</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Dec 1, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-df06492e2ee0eacc9a8c70d0e5dbacd661431ad93c70a771912344e814e64f383</citedby><cites>FETCH-LOGICAL-c394t-df06492e2ee0eacc9a8c70d0e5dbacd661431ad93c70a771912344e814e64f383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2510777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8941109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DOBBENBURGH, J. O</creatorcontrib><creatorcontrib>LAHPOR, J. R</creatorcontrib><creatorcontrib>WOOLLEY, S. R</creatorcontrib><creatorcontrib>DE JONGE, N</creatorcontrib><creatorcontrib>KLÖPPING, C</creatorcontrib><creatorcontrib>VAN ECHTELD, C. J. A</creatorcontrib><title>Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Although strict selection criteria are being used for the acceptance of human donor hearts for transplantation, problems with respect to functional recovery on reperfusion sometimes still occur. Therefore, evaluation of the viability of a human donor heart before implantation during heart transplantation may be of great value.
In the present study, the energy metabolism of 25 excised human donor hearts arrested with St Thomas' Hospital No. 2 cardioplegic solution was evaluated noninvasively by use of 31P magnetic resonance spectroscopy (MRS) before implantation and was correlated with myocardial function measured with thermodilution in heart transplant patients. No significant correlation was observed between the cardiac index of heart transplant patients during the first hours after transplantation and the phosphocreatine/ATP (r = .13, P = .54), inorganic phosphate/ATP (r = .26, P = .21), phosphomonoesters/ATP (r = .02, P = .92), or phosphocreatine/inorganic phosphate (r = .16, P = .44) ratio or the intracellular pH (r = .06, P = .78) at the time of reperfusion. However, 1 week after transplantation, a significant correlation was observed between the cardiac index and the phosphocreatine/ATP (r = .49, P = .01), phosphomonoesters/ATP (r = .45, P = .02), and phosphocreatine/inorganic phosphate (r = .40, P = .05) ratios at the time of reperfusion. In contrast, the inorganic phosphate/ATP (r = .10, P = .63) ratio and pH (r = .31, P = .13) at the time of reperfusion showed a poor correlation with the cardiac index 1 week after transplantation.
Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiac Output</subject><subject>Cryopreservation</subject><subject>Energy Metabolism</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Heart Transplantation</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Reperfusion</subject><subject>Myocardium - metabolism</subject><subject>Phosphates - metabolism</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Time Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9r3DAQxUVoSbdpPkAPBVFCb95qJNmyjmVp_kCgUNqzmJXHrINtbSW5sP301WaXHHIant5vBvQeYx9BrAEa-CpgvXn4uba6yLVsFVywFdRSV7pW9g1bCSFsZZSU79j7lJ6KbJSpL9llazWAsCv273aZfR7CjCOP5MNfigeOfabId8uEM98RxsxzxDntR5wzHmE-pEKPmKnjOfC8Iz5Rxm0YB899mLvhmQr9s7U77EOZcSpmF-YQT0c_sLc9jomuz_OK_b79_mtzXz3-uHvYfHusvLI6V10vGm0lSSJB6L3F1hvRCaq7LfquaUArwM6q8orGgAWptKYWNDW6V626Yl9Od_cx_FkoZTcNydNYfkNhSc60daMsiAJ-fgU-hSWWZJKTIBstSuQFghPkY0gpUu_2cZgwHhwIdyzFCXClFGd1ke5YStn5dD68bCfqXjbOLRT_5uxj8jj2JWw_pBdM1iCMMeo_u0uWTA</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>VAN DOBBENBURGH, J. O</creator><creator>LAHPOR, J. R</creator><creator>WOOLLEY, S. R</creator><creator>DE JONGE, N</creator><creator>KLÖPPING, C</creator><creator>VAN ECHTELD, C. J. A</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart</title><author>VAN DOBBENBURGH, J. O ; LAHPOR, J. R ; WOOLLEY, S. R ; DE JONGE, N ; KLÖPPING, C ; VAN ECHTELD, C. J. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-df06492e2ee0eacc9a8c70d0e5dbacd661431ad93c70a771912344e814e64f383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiac Output</topic><topic>Cryopreservation</topic><topic>Energy Metabolism</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Heart Transplantation</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Reperfusion</topic><topic>Myocardium - metabolism</topic><topic>Phosphates - metabolism</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DOBBENBURGH, J. O</creatorcontrib><creatorcontrib>LAHPOR, J. R</creatorcontrib><creatorcontrib>WOOLLEY, S. R</creatorcontrib><creatorcontrib>DE JONGE, N</creatorcontrib><creatorcontrib>KLÖPPING, C</creatorcontrib><creatorcontrib>VAN ECHTELD, C. J. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN DOBBENBURGH, J. O</au><au>LAHPOR, J. R</au><au>WOOLLEY, S. R</au><au>DE JONGE, N</au><au>KLÖPPING, C</au><au>VAN ECHTELD, C. J. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>94</volume><issue>11</issue><spage>2831</spage><epage>2836</epage><pages>2831-2836</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Although strict selection criteria are being used for the acceptance of human donor hearts for transplantation, problems with respect to functional recovery on reperfusion sometimes still occur. Therefore, evaluation of the viability of a human donor heart before implantation during heart transplantation may be of great value.
In the present study, the energy metabolism of 25 excised human donor hearts arrested with St Thomas' Hospital No. 2 cardioplegic solution was evaluated noninvasively by use of 31P magnetic resonance spectroscopy (MRS) before implantation and was correlated with myocardial function measured with thermodilution in heart transplant patients. No significant correlation was observed between the cardiac index of heart transplant patients during the first hours after transplantation and the phosphocreatine/ATP (r = .13, P = .54), inorganic phosphate/ATP (r = .26, P = .21), phosphomonoesters/ATP (r = .02, P = .92), or phosphocreatine/inorganic phosphate (r = .16, P = .44) ratio or the intracellular pH (r = .06, P = .78) at the time of reperfusion. However, 1 week after transplantation, a significant correlation was observed between the cardiac index and the phosphocreatine/ATP (r = .49, P = .01), phosphomonoesters/ATP (r = .45, P = .02), and phosphocreatine/inorganic phosphate (r = .40, P = .05) ratios at the time of reperfusion. In contrast, the inorganic phosphate/ATP (r = .10, P = .63) ratio and pH (r = .31, P = .13) at the time of reperfusion showed a poor correlation with the cardiac index 1 week after transplantation.
Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>8941109</pmid><doi>10.1161/01.CIR.94.11.2831</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1996-12, Vol.94 (11), p.2831-2836 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78563910 |
| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adolescent Adult Biological and medical sciences Cardiac Output Cryopreservation Energy Metabolism Female Heart - physiopathology Heart Transplantation Humans Male Medical sciences Middle Aged Myocardial Reperfusion Myocardium - metabolism Phosphates - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors |
| title | Functional recovery after human heart transplantation is related to the metabolic condition of the hypothermic donor heart |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T18%3A12%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20recovery%20after%20human%20heart%20transplantation%20is%20related%20to%20the%20metabolic%20condition%20of%20the%20hypothermic%20donor%20heart&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=VAN%20DOBBENBURGH,%20J.%20O&rft.date=1996-12-01&rft.volume=94&rft.issue=11&rft.spage=2831&rft.epage=2836&rft.pages=2831-2836&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/01.CIR.94.11.2831&rft_dat=%3Cproquest_cross%3E78563910%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=212640161&rft_id=info:pmid/8941109&rfr_iscdi=true |