Clinical Evaluation of Non-Insulin-Dependent Diabetes Mellitus Patients with Autoantibodies to Glutamic Acid Decarboxylase
We evaluated the frequency of antibodies to glutamic acid decarboxylase (GAD-Ab) in Japanese patients diagnosed initially as having non-insulin-dependent diabetes mellitus (NIDDM) and investigated a possible link between the presence of GAD-Ab and development of the insulin-dependent (ID) state. The...
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| Veröffentlicht in: | Journal of autoimmunity 1996-10, Vol.9 (5), p.683-688 |
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| container_title | Journal of autoimmunity |
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| creator | Abiru, Norio Takino, Hirofumi Yano, Mayumi Kawasaki, Eiji Yamasaki, Hironori Yamaguchi, Yoshihiko Akazawa, Shoichi Nagataki, Shigenobu |
| description | We evaluated the frequency of antibodies to glutamic acid decarboxylase (GAD-Ab) in Japanese patients diagnosed initially as having non-insulin-dependent diabetes mellitus (NIDDM) and investigated a possible link between the presence of GAD-Ab and development of the insulin-dependent (ID) state. The population sample consisted of 583 Japanese NIDDM patients (age at onset >30 years) who were initially non-ketotic and did not require insulin treatment during at least 6 months of observation. GAD-Ab were measured using radioimmunoassay. The clinical characteristics of GAD-Ab
+patients were carefully examined at four-year intervals from the onset of diabetes. We also examined the ID state by measuring the level of postprandial serum C-peptide and i.v. glucagon-stimulated serum C-peptide. The overall prevalence of GAD-Ab in Japanese NIDDM patients was 3.8%. The frequency of GAD-Ab
+did not significantly decrease with a long history of diabetes. GAD-Ab
+patients had a lower body mass index, compared with GAD-Ab
−(20.8±2.9 vs 23.0±3.7,
P |
| doi_str_mv | 10.1006/jaut.1996.0089 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78563788</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S089684119690089X</els_id><sourcerecordid>16025014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-e662cc01f42107ec335ffabd9f55acd0e9eb2d3bc88798af70667a51a639dbd3</originalsourceid><addsrcrecordid>eNqFkUFvEzEQRi0EKqFw5YbkA-K2qb0be-1jlJRSqaU99G7N2rPC1cYOa7tQfj2OEvWGOI0035vRaB4hHzlbcsbkxSOUvORayyVjSr8iC860aDQX_WuyqB3ZqBXnb8m7lB4Z41wIcUbOlO66VokF-bOZfPAWJnr5BFOB7GOgcaTfY2iuQyo1bba4x-AwZLr1MGDGRG9xmnwuid7XiZok-svnH3RdcoSQ_RCdr1SO9GoqGXbe0rX1jm7RwjzE388TJHxP3owwJfxwqufk4evlw-Zbc3N3db1Z3zS20zo3KGVrLePjquWsR9t1YhxhcHoUAqxjqHFoXTdYpXqtYOyZlD0IDrLTbnDdOflyXLuf48-CKZudT7beDwFjSaZXQna9Uv8FuWStYHxVweURtHNMacbR7Ge_g_nZcGYOUsxBijlIMQcpdeDTaXMZduhe8JOFmn8-5ZCqinGGYH16wdpV1SlYxdQRw_qtJ4-zSbY-36LzM9psXPT_uuAvD8aqxA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16025014</pqid></control><display><type>article</type><title>Clinical Evaluation of Non-Insulin-Dependent Diabetes Mellitus Patients with Autoantibodies to Glutamic Acid Decarboxylase</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Abiru, Norio ; Takino, Hirofumi ; Yano, Mayumi ; Kawasaki, Eiji ; Yamasaki, Hironori ; Yamaguchi, Yoshihiko ; Akazawa, Shoichi ; Nagataki, Shigenobu</creator><creatorcontrib>Abiru, Norio ; Takino, Hirofumi ; Yano, Mayumi ; Kawasaki, Eiji ; Yamasaki, Hironori ; Yamaguchi, Yoshihiko ; Akazawa, Shoichi ; Nagataki, Shigenobu</creatorcontrib><description>We evaluated the frequency of antibodies to glutamic acid decarboxylase (GAD-Ab) in Japanese patients diagnosed initially as having non-insulin-dependent diabetes mellitus (NIDDM) and investigated a possible link between the presence of GAD-Ab and development of the insulin-dependent (ID) state. The population sample consisted of 583 Japanese NIDDM patients (age at onset >30 years) who were initially non-ketotic and did not require insulin treatment during at least 6 months of observation. GAD-Ab were measured using radioimmunoassay. The clinical characteristics of GAD-Ab
+patients were carefully examined at four-year intervals from the onset of diabetes. We also examined the ID state by measuring the level of postprandial serum C-peptide and i.v. glucagon-stimulated serum C-peptide. The overall prevalence of GAD-Ab in Japanese NIDDM patients was 3.8%. The frequency of GAD-Ab
+did not significantly decrease with a long history of diabetes. GAD-Ab
+patients had a lower body mass index, compared with GAD-Ab
−(20.8±2.9 vs 23.0±3.7,
P<0.005), lower postprandial C-peptide levels (0.7±0.6 vs 1.4±1.2,
P<0.01), and an early commencement of insulin therapy (3.6±4.7 vs 8.3±6.6,
P<0.01). GAD-Ab
+patients who had already developed the ID state had characteristically higher titers of GAD-Ab (421.4±359.1) and a higher frequency of islet cell antibodies (ICAs) (77.8%), compared with GAD-Ab
+NID patients (titer: 60.2±86.9,
P<0.005, 23.1%,
P<0.05, respectively). GAD-Ab
+ICAs
+patients showed higher frequencies of ID state at any diabetic duration compared with GAD
−ICAs
−, while GAD-Ab
+ICAs
−patients did not differ in the frequency of the ID state from GAD
−ICAs
−. Our results suggest that the presence of both GAD-Ab and ICAs represents a high risk for IDDM in GAD-Ab
+NIDDM patients.</description><identifier>ISSN: 0896-8411</identifier><identifier>EISSN: 1095-9157</identifier><identifier>DOI: 10.1006/jaut.1996.0089</identifier><identifier>PMID: 8933285</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Autoantibodies - blood ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 2 - immunology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glutamate Decarboxylase - immunology ; glutamic acid decarboxylase antibodies ; Humans ; insulin-dependent diabetes mellitus ; islet cell antibodies ; Male ; Medical sciences ; Middle Aged ; non-insulin-dependent diabetes mellitus</subject><ispartof>Journal of autoimmunity, 1996-10, Vol.9 (5), p.683-688</ispartof><rights>1996 Academic Press</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-e662cc01f42107ec335ffabd9f55acd0e9eb2d3bc88798af70667a51a639dbd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/jaut.1996.0089$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2491550$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8933285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abiru, Norio</creatorcontrib><creatorcontrib>Takino, Hirofumi</creatorcontrib><creatorcontrib>Yano, Mayumi</creatorcontrib><creatorcontrib>Kawasaki, Eiji</creatorcontrib><creatorcontrib>Yamasaki, Hironori</creatorcontrib><creatorcontrib>Yamaguchi, Yoshihiko</creatorcontrib><creatorcontrib>Akazawa, Shoichi</creatorcontrib><creatorcontrib>Nagataki, Shigenobu</creatorcontrib><title>Clinical Evaluation of Non-Insulin-Dependent Diabetes Mellitus Patients with Autoantibodies to Glutamic Acid Decarboxylase</title><title>Journal of autoimmunity</title><addtitle>J Autoimmun</addtitle><description>We evaluated the frequency of antibodies to glutamic acid decarboxylase (GAD-Ab) in Japanese patients diagnosed initially as having non-insulin-dependent diabetes mellitus (NIDDM) and investigated a possible link between the presence of GAD-Ab and development of the insulin-dependent (ID) state. The population sample consisted of 583 Japanese NIDDM patients (age at onset >30 years) who were initially non-ketotic and did not require insulin treatment during at least 6 months of observation. GAD-Ab were measured using radioimmunoassay. The clinical characteristics of GAD-Ab
+patients were carefully examined at four-year intervals from the onset of diabetes. We also examined the ID state by measuring the level of postprandial serum C-peptide and i.v. glucagon-stimulated serum C-peptide. The overall prevalence of GAD-Ab in Japanese NIDDM patients was 3.8%. The frequency of GAD-Ab
+did not significantly decrease with a long history of diabetes. GAD-Ab
+patients had a lower body mass index, compared with GAD-Ab
−(20.8±2.9 vs 23.0±3.7,
P<0.005), lower postprandial C-peptide levels (0.7±0.6 vs 1.4±1.2,
P<0.01), and an early commencement of insulin therapy (3.6±4.7 vs 8.3±6.6,
P<0.01). GAD-Ab
+patients who had already developed the ID state had characteristically higher titers of GAD-Ab (421.4±359.1) and a higher frequency of islet cell antibodies (ICAs) (77.8%), compared with GAD-Ab
+NID patients (titer: 60.2±86.9,
P<0.005, 23.1%,
P<0.05, respectively). GAD-Ab
+ICAs
+patients showed higher frequencies of ID state at any diabetic duration compared with GAD
−ICAs
−, while GAD-Ab
+ICAs
−patients did not differ in the frequency of the ID state from GAD
−ICAs
−. Our results suggest that the presence of both GAD-Ab and ICAs represents a high risk for IDDM in GAD-Ab
+NIDDM patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Glutamate Decarboxylase - immunology</subject><subject>glutamic acid decarboxylase antibodies</subject><subject>Humans</subject><subject>insulin-dependent diabetes mellitus</subject><subject>islet cell antibodies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>non-insulin-dependent diabetes mellitus</subject><issn>0896-8411</issn><issn>1095-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvEzEQRi0EKqFw5YbkA-K2qb0be-1jlJRSqaU99G7N2rPC1cYOa7tQfj2OEvWGOI0035vRaB4hHzlbcsbkxSOUvORayyVjSr8iC860aDQX_WuyqB3ZqBXnb8m7lB4Z41wIcUbOlO66VokF-bOZfPAWJnr5BFOB7GOgcaTfY2iuQyo1bba4x-AwZLr1MGDGRG9xmnwuid7XiZok-svnH3RdcoSQ_RCdr1SO9GoqGXbe0rX1jm7RwjzE388TJHxP3owwJfxwqufk4evlw-Zbc3N3db1Z3zS20zo3KGVrLePjquWsR9t1YhxhcHoUAqxjqHFoXTdYpXqtYOyZlD0IDrLTbnDdOflyXLuf48-CKZudT7beDwFjSaZXQna9Uv8FuWStYHxVweURtHNMacbR7Ge_g_nZcGYOUsxBijlIMQcpdeDTaXMZduhe8JOFmn8-5ZCqinGGYH16wdpV1SlYxdQRw_qtJ4-zSbY-36LzM9psXPT_uuAvD8aqxA</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Abiru, Norio</creator><creator>Takino, Hirofumi</creator><creator>Yano, Mayumi</creator><creator>Kawasaki, Eiji</creator><creator>Yamasaki, Hironori</creator><creator>Yamaguchi, Yoshihiko</creator><creator>Akazawa, Shoichi</creator><creator>Nagataki, Shigenobu</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>Clinical Evaluation of Non-Insulin-Dependent Diabetes Mellitus Patients with Autoantibodies to Glutamic Acid Decarboxylase</title><author>Abiru, Norio ; Takino, Hirofumi ; Yano, Mayumi ; Kawasaki, Eiji ; Yamasaki, Hironori ; Yamaguchi, Yoshihiko ; Akazawa, Shoichi ; Nagataki, Shigenobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-e662cc01f42107ec335ffabd9f55acd0e9eb2d3bc88798af70667a51a639dbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Glutamate Decarboxylase - immunology</topic><topic>glutamic acid decarboxylase antibodies</topic><topic>Humans</topic><topic>insulin-dependent diabetes mellitus</topic><topic>islet cell antibodies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>non-insulin-dependent diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abiru, Norio</creatorcontrib><creatorcontrib>Takino, Hirofumi</creatorcontrib><creatorcontrib>Yano, Mayumi</creatorcontrib><creatorcontrib>Kawasaki, Eiji</creatorcontrib><creatorcontrib>Yamasaki, Hironori</creatorcontrib><creatorcontrib>Yamaguchi, Yoshihiko</creatorcontrib><creatorcontrib>Akazawa, Shoichi</creatorcontrib><creatorcontrib>Nagataki, Shigenobu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of autoimmunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abiru, Norio</au><au>Takino, Hirofumi</au><au>Yano, Mayumi</au><au>Kawasaki, Eiji</au><au>Yamasaki, Hironori</au><au>Yamaguchi, Yoshihiko</au><au>Akazawa, Shoichi</au><au>Nagataki, Shigenobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Evaluation of Non-Insulin-Dependent Diabetes Mellitus Patients with Autoantibodies to Glutamic Acid Decarboxylase</atitle><jtitle>Journal of autoimmunity</jtitle><addtitle>J Autoimmun</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>9</volume><issue>5</issue><spage>683</spage><epage>688</epage><pages>683-688</pages><issn>0896-8411</issn><eissn>1095-9157</eissn><abstract>We evaluated the frequency of antibodies to glutamic acid decarboxylase (GAD-Ab) in Japanese patients diagnosed initially as having non-insulin-dependent diabetes mellitus (NIDDM) and investigated a possible link between the presence of GAD-Ab and development of the insulin-dependent (ID) state. The population sample consisted of 583 Japanese NIDDM patients (age at onset >30 years) who were initially non-ketotic and did not require insulin treatment during at least 6 months of observation. GAD-Ab were measured using radioimmunoassay. The clinical characteristics of GAD-Ab
+patients were carefully examined at four-year intervals from the onset of diabetes. We also examined the ID state by measuring the level of postprandial serum C-peptide and i.v. glucagon-stimulated serum C-peptide. The overall prevalence of GAD-Ab in Japanese NIDDM patients was 3.8%. The frequency of GAD-Ab
+did not significantly decrease with a long history of diabetes. GAD-Ab
+patients had a lower body mass index, compared with GAD-Ab
−(20.8±2.9 vs 23.0±3.7,
P<0.005), lower postprandial C-peptide levels (0.7±0.6 vs 1.4±1.2,
P<0.01), and an early commencement of insulin therapy (3.6±4.7 vs 8.3±6.6,
P<0.01). GAD-Ab
+patients who had already developed the ID state had characteristically higher titers of GAD-Ab (421.4±359.1) and a higher frequency of islet cell antibodies (ICAs) (77.8%), compared with GAD-Ab
+NID patients (titer: 60.2±86.9,
P<0.005, 23.1%,
P<0.05, respectively). GAD-Ab
+ICAs
+patients showed higher frequencies of ID state at any diabetic duration compared with GAD
−ICAs
−, while GAD-Ab
+ICAs
−patients did not differ in the frequency of the ID state from GAD
−ICAs
−. Our results suggest that the presence of both GAD-Ab and ICAs represents a high risk for IDDM in GAD-Ab
+NIDDM patients.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>8933285</pmid><doi>10.1006/jaut.1996.0089</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-8411 |
| ispartof | Journal of autoimmunity, 1996-10, Vol.9 (5), p.683-688 |
| issn | 0896-8411 1095-9157 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Autoantibodies - blood Biological and medical sciences Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 2 - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glutamate Decarboxylase - immunology glutamic acid decarboxylase antibodies Humans insulin-dependent diabetes mellitus islet cell antibodies Male Medical sciences Middle Aged non-insulin-dependent diabetes mellitus |
| title | Clinical Evaluation of Non-Insulin-Dependent Diabetes Mellitus Patients with Autoantibodies to Glutamic Acid Decarboxylase |
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