Human tumor necrosis factor-alpha receptor. Purification by immunoaffinity chromatography and initial characterization

The receptor for human tumor necrosis factor-alpha (TNF-alpha) was isolated from a subclone of the human histiocytic lymphoma cell line U937. These cells exhibit a single class of high affinity receptors (Kd = 0.51 +/- 0.25 nM) with an average density of 55,000 +/- 5,000 binding sites/cell. After so...

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Veröffentlicht in:	The Journal of biological chemistry 1988-12, Vol.263 (35), p.19098-19104
Hauptverfasser:	Stauber, G B, Aiyer, R A, Aggarwal, B B
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Biological and medical sciences Cell Line Cell receptors Cell structures and functions Chromatography, Affinity Chromatography, Gel Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Humans Kinetics Molecular and cellular biology Molecular Weight Receptors, Cell Surface - isolation & purification Receptors, Tumor Necrosis Factor Solubility tumor necrosis factor- alpha
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