In vitro effect of TP-1 (a calf thymic extract) on suppressor T-cell function of patients with autoimmune chronic active hepatitis
Concanavalin A-activated T-lymphocyte suppression of IgG production was found to be significantly impaired in patients with untreated active autoimmune chronic hepatitis when compared to normals or patients with inactive disease. When the dose-response effect of TP-1, a calf thymic extract, on in vi...
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| Veröffentlicht in: | International journal of immunopharmacology 1988, Vol.10 (6), p.651-656 |
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| container_title | International journal of immunopharmacology |
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| creator | O'Brien, C.J. Nouri-Aria, K.T. Hegarty, J.E. Vento, S. Eddleston, A.L.W.F. Williams, Roger |
| description | Concanavalin A-activated T-lymphocyte suppression of IgG production was found to be significantly impaired in patients with untreated active autoimmune chronic hepatitis when compared to normals or patients with inactive disease.
When the dose-response effect of TP-1, a calf thymic extract, on
in vitro suppressor cell activity was assessed, lymphocytes from six out of eight patients with previously reduced suppressor cell function showed a significant improvement, while over a similar range the suppressor cell activity of most normal controls declined. These results support the possibility that defective immunoregulation in patients with autoimmune chronic active hepatitis may be related to a deficiency in thymic hormone levels. |
| doi_str_mv | 10.1016/0192-0561(88)90018-5 |
| format | Article |
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When the dose-response effect of TP-1, a calf thymic extract, on
in vitro suppressor cell activity was assessed, lymphocytes from six out of eight patients with previously reduced suppressor cell function showed a significant improvement, while over a similar range the suppressor cell activity of most normal controls declined. These results support the possibility that defective immunoregulation in patients with autoimmune chronic active hepatitis may be related to a deficiency in thymic hormone levels.</description><identifier>ISSN: 0192-0561</identifier><identifier>EISSN: 1879-3495</identifier><identifier>DOI: 10.1016/0192-0561(88)90018-5</identifier><identifier>PMID: 2974021</identifier><identifier>CODEN: IJIMDS</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Adjuvants, Immunologic - pharmacology ; Adult ; Aged ; Autoimmune Diseases - drug therapy ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Concanavalin A - pharmacology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis, Chronic - drug therapy ; Hepatitis, Chronic - immunology ; Humans ; Immunoglobulin G - biosynthesis ; In Vitro Techniques ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; T-Lymphocytes, Regulatory - drug effects ; T-Lymphocytes, Regulatory - immunology ; Thymus Extracts - pharmacology</subject><ispartof>International journal of immunopharmacology, 1988, Vol.10 (6), p.651-656</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-9e81dbbf464385b1743b6dba989d81c59afbe36aab5645e2702edc8735f895853</citedby><cites>FETCH-LOGICAL-c332t-9e81dbbf464385b1743b6dba989d81c59afbe36aab5645e2702edc8735f895853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27906,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7003139$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2974021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Brien, C.J.</creatorcontrib><creatorcontrib>Nouri-Aria, K.T.</creatorcontrib><creatorcontrib>Hegarty, J.E.</creatorcontrib><creatorcontrib>Vento, S.</creatorcontrib><creatorcontrib>Eddleston, A.L.W.F.</creatorcontrib><creatorcontrib>Williams, Roger</creatorcontrib><title>In vitro effect of TP-1 (a calf thymic extract) on suppressor T-cell function of patients with autoimmune chronic active hepatitis</title><title>International journal of immunopharmacology</title><addtitle>Int J Immunopharmacol</addtitle><description>Concanavalin A-activated T-lymphocyte suppression of IgG production was found to be significantly impaired in patients with untreated active autoimmune chronic hepatitis when compared to normals or patients with inactive disease.
When the dose-response effect of TP-1, a calf thymic extract, on
in vitro suppressor cell activity was assessed, lymphocytes from six out of eight patients with previously reduced suppressor cell function showed a significant improvement, while over a similar range the suppressor cell activity of most normal controls declined. These results support the possibility that defective immunoregulation in patients with autoimmune chronic active hepatitis may be related to a deficiency in thymic hormone levels.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Adult</subject><subject>Aged</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Concanavalin A - pharmacology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis, Chronic - drug therapy</subject><subject>Hepatitis, Chronic - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>In Vitro Techniques</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Thymus Extracts - pharmacology</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo67j6DxRyENk9tCadj04uC7L4sbCgh_Ec0ukKE5nutEl6dK_-ctPOMEc91eF96qWoB6GXlLylhMp3hOq2IULSK6WuNSFUNeIR2lDV6YZxLR6jzRl5ip7l_J0QIqhsL9BFqztOWrpBv-8mfAglRQzegys4erz92lB8ZbGze4_L7mEMDsOvkqwr1zhOOC_znCDnmPC2cbDfY79MroQa1e3ZlgBTyfhnKDtslxLDOC4TYLdLcapVtSYcAO9gJUvIz9ETb_cZXpzmJfr28cP29nNz_-XT3e37-8Yx1pZGg6JD33suOVOipx1nvRx6q5UeFHVCW98Dk9b2QnIBbUdaGJzqmPBKCyXYJXpz7J1T_LFALmYMeT3fThCXbDolJGul_C9IBeH1jbyC_Ai6FHNO4M2cwmjTg6HErI7MKsCsAoxS5q8jsx7y6tS_9CMM56WTlJq_PuU2rw6SnVzIZ6wjhFGmK3ZzxKA-7RAgmezq5x0MIVWTZojh33f8AeAqrbY</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>O'Brien, C.J.</creator><creator>Nouri-Aria, K.T.</creator><creator>Hegarty, J.E.</creator><creator>Vento, S.</creator><creator>Eddleston, A.L.W.F.</creator><creator>Williams, Roger</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>In vitro effect of TP-1 (a calf thymic extract) on suppressor T-cell function of patients with autoimmune chronic active hepatitis</title><author>O'Brien, C.J. ; Nouri-Aria, K.T. ; Hegarty, J.E. ; Vento, S. ; Eddleston, A.L.W.F. ; Williams, Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-9e81dbbf464385b1743b6dba989d81c59afbe36aab5645e2702edc8735f895853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Adult</topic><topic>Aged</topic><topic>Autoimmune Diseases - drug therapy</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Concanavalin A - pharmacology</topic><topic>Female</topic><topic>Gastroenterology. 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When the dose-response effect of TP-1, a calf thymic extract, on
in vitro suppressor cell activity was assessed, lymphocytes from six out of eight patients with previously reduced suppressor cell function showed a significant improvement, while over a similar range the suppressor cell activity of most normal controls declined. These results support the possibility that defective immunoregulation in patients with autoimmune chronic active hepatitis may be related to a deficiency in thymic hormone levels.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>2974021</pmid><doi>10.1016/0192-0561(88)90018-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of immunopharmacology, 1988, Vol.10 (6), p.651-656 |
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| subjects | Adjuvants, Immunologic - pharmacology Adult Aged Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Biological and medical sciences Concanavalin A - pharmacology Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis, Chronic - drug therapy Hepatitis, Chronic - immunology Humans Immunoglobulin G - biosynthesis In Vitro Techniques Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Thymus Extracts - pharmacology |
| title | In vitro effect of TP-1 (a calf thymic extract) on suppressor T-cell function of patients with autoimmune chronic active hepatitis |
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