Action of cyclic AMP on intracellular calcium concentration and bursting activity
In order to clarify its role in the provocation of seizure activity, the effects of cyclic AMP were examined on the intracellular calcium concentration of pentylenetetrazol (PTZ)-sensitive neurons as well as of PTZ-non-sensitive neurons of the Japanese land snail, Euhadra peliomphala. Extracellular...
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| Veröffentlicht in: | Epilepsy research 1988-09, Vol.2 (5), p.317-322 |
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| creator | Sugaya, Eiichi Furuichi, Hiroyasu Takagi, Tamaki Kajiwara, Kagemasa Komatsubara, Junichi Sugaya, Aiko |
| description | In order to clarify its role in the provocation of seizure activity, the effects of cyclic AMP were examined on the intracellular calcium concentration of pentylenetetrazol (PTZ)-sensitive neurons as well as of PTZ-non-sensitive neurons of the Japanese land snail,
Euhadra peliomphala. Extracellular application of isobutylmethylxanthine (IBMX) and dibutyryl cyclic AMP showed bursting activity-like firing in the PTZ-sensitive neurons. When 5′-guanylylimidodiphosphate (GNP-PNP) was injected into PTZ-sensitive neurons in the extracellular presence of IBMX and dibutyryl cyclic AMP, bursting activity followed by long-lasting hyperpolarization occurred. Intracellular injection of cyclic AMP into PTZ-sensitive neurons caused hyperpolarization coincident with an increase in intracellular calcium concentration. This increase in intracellular calcium concentration was the same under conditions in which the calcium influx was inhibited by the substitution of extracellular calcium chloride by cobalt chloride. In PTZ-non-sensitive neurons, cyclic AMP-induced bursting activity was not observed. These results suggest that an increase in cyclic AMP provoked bursting activity via an increase in intracellular calcium concentration. |
| doi_str_mv | 10.1016/0920-1211(88)90040-X |
| format | Article |
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Euhadra peliomphala. Extracellular application of isobutylmethylxanthine (IBMX) and dibutyryl cyclic AMP showed bursting activity-like firing in the PTZ-sensitive neurons. When 5′-guanylylimidodiphosphate (GNP-PNP) was injected into PTZ-sensitive neurons in the extracellular presence of IBMX and dibutyryl cyclic AMP, bursting activity followed by long-lasting hyperpolarization occurred. Intracellular injection of cyclic AMP into PTZ-sensitive neurons caused hyperpolarization coincident with an increase in intracellular calcium concentration. This increase in intracellular calcium concentration was the same under conditions in which the calcium influx was inhibited by the substitution of extracellular calcium chloride by cobalt chloride. In PTZ-non-sensitive neurons, cyclic AMP-induced bursting activity was not observed. These results suggest that an increase in cyclic AMP provoked bursting activity via an increase in intracellular calcium concentration.</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/0920-1211(88)90040-X</identifier><identifier>PMID: 2461857</identifier><identifier>CODEN: EPIRE8</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>1-Methyl-3-isobutylxanthine - pharmacology ; Action Potentials - drug effects ; Animals ; Biochemistry. Physiology. Immunology ; Biological and medical sciences ; Bursting activity ; Calcium - physiology ; Cyclic AMP ; Cyclic AMP - pharmacology ; Epilepsy ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Intracellular calcium ; Invertebrates ; Membrane Potentials - drug effects ; Mollusca ; Neurons - drug effects ; Neurons - physiology ; Pentylenetetrazole ; Physiology. Development ; Seizure ; Snails</subject><ispartof>Epilepsy research, 1988-09, Vol.2 (5), p.317-322</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-eb11e865faaf76d8c071755297b033b3869bd70e3aa4aa31a289636930f00a33</citedby><cites>FETCH-LOGICAL-c386t-eb11e865faaf76d8c071755297b033b3869bd70e3aa4aa31a289636930f00a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0920-1211(88)90040-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7325516$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2461857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugaya, Eiichi</creatorcontrib><creatorcontrib>Furuichi, Hiroyasu</creatorcontrib><creatorcontrib>Takagi, Tamaki</creatorcontrib><creatorcontrib>Kajiwara, Kagemasa</creatorcontrib><creatorcontrib>Komatsubara, Junichi</creatorcontrib><creatorcontrib>Sugaya, Aiko</creatorcontrib><title>Action of cyclic AMP on intracellular calcium concentration and bursting activity</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>In order to clarify its role in the provocation of seizure activity, the effects of cyclic AMP were examined on the intracellular calcium concentration of pentylenetetrazol (PTZ)-sensitive neurons as well as of PTZ-non-sensitive neurons of the Japanese land snail,
Euhadra peliomphala. Extracellular application of isobutylmethylxanthine (IBMX) and dibutyryl cyclic AMP showed bursting activity-like firing in the PTZ-sensitive neurons. When 5′-guanylylimidodiphosphate (GNP-PNP) was injected into PTZ-sensitive neurons in the extracellular presence of IBMX and dibutyryl cyclic AMP, bursting activity followed by long-lasting hyperpolarization occurred. Intracellular injection of cyclic AMP into PTZ-sensitive neurons caused hyperpolarization coincident with an increase in intracellular calcium concentration. This increase in intracellular calcium concentration was the same under conditions in which the calcium influx was inhibited by the substitution of extracellular calcium chloride by cobalt chloride. In PTZ-non-sensitive neurons, cyclic AMP-induced bursting activity was not observed. These results suggest that an increase in cyclic AMP provoked bursting activity via an increase in intracellular calcium concentration.</description><subject>1-Methyl-3-isobutylxanthine - pharmacology</subject><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Biochemistry. Physiology. Immunology</subject><subject>Biological and medical sciences</subject><subject>Bursting activity</subject><subject>Calcium - physiology</subject><subject>Cyclic AMP</subject><subject>Cyclic AMP - pharmacology</subject><subject>Epilepsy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Intracellular calcium</subject><subject>Invertebrates</subject><subject>Membrane Potentials - drug effects</subject><subject>Mollusca</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Pentylenetetrazole</subject><subject>Physiology. Development</subject><subject>Seizure</subject><subject>Snails</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOj7-gUIXIrqo3jRpkm6EYfAFigouZhdu01QinVaTdmD-vakzzNJVIOc7h8tHyCmFawpU3ECRQUozSi-VuioAOKTzHTKhSmapUJzvkskWOSCHIXwBgATO98l-xgVVuZyQ96npXdcmXZ2YlWmcSaYvb0n8cG3v0dimGRr0icHGuGGRmK41dkz-SthWSTn40Lv2M8E4tHT96pjs1dgEe7J5j8jH_d3H7DF9fn14mk2fU8OU6FNbUmqVyGvEWopKGZBU5nlWyBIYKyNTlJUEyxA5IqOYqUIwUTCoAZCxI3Kxnv323c9gQ68XLoz3Ymu7IWipcpHxIo8gX4PGdyF4W-tv7xboV5qCHkXq0ZIeLWml9J9IPY-1s83-UC5stS1tzMX8fJNjiHZqj61xYYtJluU5FRG7XWM2qlg663UwzkaJlfPW9Lrq3P93_AL2nI6I</recordid><startdate>19880901</startdate><enddate>19880901</enddate><creator>Sugaya, Eiichi</creator><creator>Furuichi, Hiroyasu</creator><creator>Takagi, Tamaki</creator><creator>Kajiwara, Kagemasa</creator><creator>Komatsubara, Junichi</creator><creator>Sugaya, Aiko</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880901</creationdate><title>Action of cyclic AMP on intracellular calcium concentration and bursting activity</title><author>Sugaya, Eiichi ; Furuichi, Hiroyasu ; Takagi, Tamaki ; Kajiwara, Kagemasa ; Komatsubara, Junichi ; Sugaya, Aiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-eb11e865faaf76d8c071755297b033b3869bd70e3aa4aa31a289636930f00a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>1-Methyl-3-isobutylxanthine - pharmacology</topic><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Biochemistry. Physiology. Immunology</topic><topic>Biological and medical sciences</topic><topic>Bursting activity</topic><topic>Calcium - physiology</topic><topic>Cyclic AMP</topic><topic>Cyclic AMP - pharmacology</topic><topic>Epilepsy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Intracellular calcium</topic><topic>Invertebrates</topic><topic>Membrane Potentials - drug effects</topic><topic>Mollusca</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Pentylenetetrazole</topic><topic>Physiology. Development</topic><topic>Seizure</topic><topic>Snails</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugaya, Eiichi</creatorcontrib><creatorcontrib>Furuichi, Hiroyasu</creatorcontrib><creatorcontrib>Takagi, Tamaki</creatorcontrib><creatorcontrib>Kajiwara, Kagemasa</creatorcontrib><creatorcontrib>Komatsubara, Junichi</creatorcontrib><creatorcontrib>Sugaya, Aiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugaya, Eiichi</au><au>Furuichi, Hiroyasu</au><au>Takagi, Tamaki</au><au>Kajiwara, Kagemasa</au><au>Komatsubara, Junichi</au><au>Sugaya, Aiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Action of cyclic AMP on intracellular calcium concentration and bursting activity</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>1988-09-01</date><risdate>1988</risdate><volume>2</volume><issue>5</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><issn>0920-1211</issn><eissn>1872-6844</eissn><coden>EPIRE8</coden><abstract>In order to clarify its role in the provocation of seizure activity, the effects of cyclic AMP were examined on the intracellular calcium concentration of pentylenetetrazol (PTZ)-sensitive neurons as well as of PTZ-non-sensitive neurons of the Japanese land snail,
Euhadra peliomphala. Extracellular application of isobutylmethylxanthine (IBMX) and dibutyryl cyclic AMP showed bursting activity-like firing in the PTZ-sensitive neurons. When 5′-guanylylimidodiphosphate (GNP-PNP) was injected into PTZ-sensitive neurons in the extracellular presence of IBMX and dibutyryl cyclic AMP, bursting activity followed by long-lasting hyperpolarization occurred. Intracellular injection of cyclic AMP into PTZ-sensitive neurons caused hyperpolarization coincident with an increase in intracellular calcium concentration. This increase in intracellular calcium concentration was the same under conditions in which the calcium influx was inhibited by the substitution of extracellular calcium chloride by cobalt chloride. In PTZ-non-sensitive neurons, cyclic AMP-induced bursting activity was not observed. These results suggest that an increase in cyclic AMP provoked bursting activity via an increase in intracellular calcium concentration.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2461857</pmid><doi>10.1016/0920-1211(88)90040-X</doi><tpages>6</tpages></addata></record> |
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| subjects | 1-Methyl-3-isobutylxanthine - pharmacology Action Potentials - drug effects Animals Biochemistry. Physiology. Immunology Biological and medical sciences Bursting activity Calcium - physiology Cyclic AMP Cyclic AMP - pharmacology Epilepsy Fundamental and applied biological sciences. Psychology In Vitro Techniques Intracellular calcium Invertebrates Membrane Potentials - drug effects Mollusca Neurons - drug effects Neurons - physiology Pentylenetetrazole Physiology. Development Seizure Snails |
| title | Action of cyclic AMP on intracellular calcium concentration and bursting activity |
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