Comparison of Target Organ Damage in Renovascular and Essential Hypertension
In many reports, the prevalence of target organ damage in renovascular hypertension (RVH) appears to be higher than in essential hypertension (EH). Since in most studies the renal artery stenosis is part of a diffuse atherosclerotic disease, it is not known whether these complications are due to RVH...
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| Veröffentlicht in: | American journal of hypertension 1996-11, Vol.9 (11), p.1062-1067 |
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| creator | Losito, Attilio Fagugli, Riccardo Maria Zampi, Ivano Parente, Basso de Rango, Paola Giordano, Giuseppe Cao, Piergiorgio |
| description | In many reports, the prevalence of target organ damage in renovascular hypertension (RVH) appears to be higher than in essential hypertension (EH). Since in most studies the renal artery stenosis is part of a diffuse atherosclerotic disease, it is not known whether these complications are due to RVH itself or to the vascular disease.
We have undertaken a case control study of 92 patients divided into two groups (46 in each), one with RVH and the other with EH and abdominal aortic aneurysm, with a comparable degree of diffuse atherosclerotic vascular disease. The vascular state of the extracranial carotid arteries and abdominal and inferior limb districts was investigated with angiography and sonography. The prevalence of left ventricular hypertrophy (LVH) and ischemic heart disease (IHD) were assessed by electrocardiography. Serum creatinine and urinary protein excretion were employed in the renal evaluation. While the analysis of the results confirmed an even diffusion of atherosclerotic vascular disease between the two groups, a significant difference was found in the prevalence of heart and renal damage. LVH was present in 32.6% of RVH patients versus 10.8% in EH (
P = .02). Serum creatinine > 1.4 mg/dL was found in 50% of RVH and in 23.9% of EH, (
P = .01). The prevalence of proteinuria in RVH was also higher although not reaching the statistical significance. The results suggest that, in patients with comparable degrees of atherosclerotic vascular disease, RVH is responsible for the higher prevalence of target organ damage in this condition compared to those with EH. Am J Hypertens 1996;9:1062–1067 |
| doi_str_mv | 10.1016/0895-7061(96)00199-9 |
| format | Article |
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We have undertaken a case control study of 92 patients divided into two groups (46 in each), one with RVH and the other with EH and abdominal aortic aneurysm, with a comparable degree of diffuse atherosclerotic vascular disease. The vascular state of the extracranial carotid arteries and abdominal and inferior limb districts was investigated with angiography and sonography. The prevalence of left ventricular hypertrophy (LVH) and ischemic heart disease (IHD) were assessed by electrocardiography. Serum creatinine and urinary protein excretion were employed in the renal evaluation. While the analysis of the results confirmed an even diffusion of atherosclerotic vascular disease between the two groups, a significant difference was found in the prevalence of heart and renal damage. LVH was present in 32.6% of RVH patients versus 10.8% in EH (
P = .02). Serum creatinine > 1.4 mg/dL was found in 50% of RVH and in 23.9% of EH, (
P = .01). The prevalence of proteinuria in RVH was also higher although not reaching the statistical significance. The results suggest that, in patients with comparable degrees of atherosclerotic vascular disease, RVH is responsible for the higher prevalence of target organ damage in this condition compared to those with EH. Am J Hypertens 1996;9:1062–1067</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/0895-7061(96)00199-9</identifier><identifier>PMID: 8931830</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Arterial hypertension. Arterial hypotension ; Arteriosclerosis - complications ; Arteriosclerosis - diagnostic imaging ; Arteriosclerosis - epidemiology ; atherosclerotic vascular disease ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiology. Vascular system ; Carotid Arteries - diagnostic imaging ; Case-Control Studies ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Creatinine - blood ; Cross-Sectional Studies ; Echocardiography, Doppler, Color ; Electrocardiography ; end-organ damage ; Female ; Humans ; Hypertension - complications ; Hypertension - pathology ; Hypertension, Renovascular - complications ; Hypertension, Renovascular - pathology ; Hypertrophy, Left Ventricular - complications ; Hypertrophy, Left Ventricular - diagnosis ; Hypertrophy, Left Ventricular - epidemiology ; Kidney - pathology ; Male ; Medical sciences ; Middle Aged ; Myocardial Ischemia - complications ; Myocardial Ischemia - diagnosis ; Myocardial Ischemia - epidemiology ; Myocardium - pathology ; Prevalence ; Proteinuria - complications ; Proteinuria - epidemiology ; Radiography ; Renal Artery Obstruction - complications ; Renovascular hypertension</subject><ispartof>American journal of hypertension, 1996-11, Vol.9 (11), p.1062-1067</ispartof><rights>1996 American Journal of Hypertension, Ltd.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-f63835410032c367d6f841603522e1a518fa544799c900c387a1dd87f9e48d463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2499186$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8931830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Losito, Attilio</creatorcontrib><creatorcontrib>Fagugli, Riccardo Maria</creatorcontrib><creatorcontrib>Zampi, Ivano</creatorcontrib><creatorcontrib>Parente, Basso</creatorcontrib><creatorcontrib>de Rango, Paola</creatorcontrib><creatorcontrib>Giordano, Giuseppe</creatorcontrib><creatorcontrib>Cao, Piergiorgio</creatorcontrib><title>Comparison of Target Organ Damage in Renovascular and Essential Hypertension</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>In many reports, the prevalence of target organ damage in renovascular hypertension (RVH) appears to be higher than in essential hypertension (EH). Since in most studies the renal artery stenosis is part of a diffuse atherosclerotic disease, it is not known whether these complications are due to RVH itself or to the vascular disease.
We have undertaken a case control study of 92 patients divided into two groups (46 in each), one with RVH and the other with EH and abdominal aortic aneurysm, with a comparable degree of diffuse atherosclerotic vascular disease. The vascular state of the extracranial carotid arteries and abdominal and inferior limb districts was investigated with angiography and sonography. The prevalence of left ventricular hypertrophy (LVH) and ischemic heart disease (IHD) were assessed by electrocardiography. Serum creatinine and urinary protein excretion were employed in the renal evaluation. While the analysis of the results confirmed an even diffusion of atherosclerotic vascular disease between the two groups, a significant difference was found in the prevalence of heart and renal damage. LVH was present in 32.6% of RVH patients versus 10.8% in EH (
P = .02). Serum creatinine > 1.4 mg/dL was found in 50% of RVH and in 23.9% of EH, (
P = .01). The prevalence of proteinuria in RVH was also higher although not reaching the statistical significance. The results suggest that, in patients with comparable degrees of atherosclerotic vascular disease, RVH is responsible for the higher prevalence of target organ damage in this condition compared to those with EH. Am J Hypertens 1996;9:1062–1067</description><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - diagnostic imaging</subject><subject>Arteriosclerosis - epidemiology</subject><subject>atherosclerotic vascular disease</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Case-Control Studies</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Creatinine - blood</subject><subject>Cross-Sectional Studies</subject><subject>Echocardiography, Doppler, Color</subject><subject>Electrocardiography</subject><subject>end-organ damage</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - pathology</subject><subject>Hypertension, Renovascular - complications</subject><subject>Hypertension, Renovascular - pathology</subject><subject>Hypertrophy, Left Ventricular - complications</subject><subject>Hypertrophy, Left Ventricular - diagnosis</subject><subject>Hypertrophy, Left Ventricular - epidemiology</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Myocardial Ischemia - epidemiology</subject><subject>Myocardium - pathology</subject><subject>Prevalence</subject><subject>Proteinuria - complications</subject><subject>Proteinuria - epidemiology</subject><subject>Radiography</subject><subject>Renal Artery Obstruction - complications</subject><subject>Renovascular hypertension</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFEEQhhsxxDX6DxTmIEEPo93T3xchbBI3sBCUVcRLU_bULK0z3Wv3bDD_3hl22aOnoniftygeQl4x-p5Rpj5QY2WtqWJvrXpHKbO2tk_Ighlta2apfEoWJ-QZeV7KL0qpUIqdk3NjOTOcLsh6mYYd5FBSrFJXbSBvcazu8xZidQ0DbLEKsfqCMT1A8fsecgWxrW5KwTgG6KvV4w7ziLGEFF-Qsw76gi-P84J8vb3ZLFf1-v7T3fJqXXup5Fh3ihsuBaOUN54r3arOCKYol02DDCQzHUghtLXeUuq50cDa1ujOojCtUPyCXB7u7nL6s8cyuiEUj30PEdO-OG2kagTXEygOoM-plIyd2-UwQH50jLpZopsNudmQs9MyS3R2qr0-3t__HLA9lY7WpvzNMZ-cQN9liD6UE9YIa5mZ36wPWCgj_j3FkH87pbmWbvX9h7Obz7d8fb103yb-44HHyd1DwOyKDxg9tiGjH12bwv___gez4pr_</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Losito, Attilio</creator><creator>Fagugli, Riccardo Maria</creator><creator>Zampi, Ivano</creator><creator>Parente, Basso</creator><creator>de Rango, Paola</creator><creator>Giordano, Giuseppe</creator><creator>Cao, Piergiorgio</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Comparison of Target Organ Damage in Renovascular and Essential Hypertension</title><author>Losito, Attilio ; Fagugli, Riccardo Maria ; Zampi, Ivano ; Parente, Basso ; de Rango, Paola ; Giordano, Giuseppe ; Cao, Piergiorgio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-f63835410032c367d6f841603522e1a518fa544799c900c387a1dd87f9e48d463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Arteriosclerosis - complications</topic><topic>Arteriosclerosis - diagnostic imaging</topic><topic>Arteriosclerosis - epidemiology</topic><topic>atherosclerotic vascular disease</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Case-Control Studies</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Creatinine - blood</topic><topic>Cross-Sectional Studies</topic><topic>Echocardiography, Doppler, Color</topic><topic>Electrocardiography</topic><topic>end-organ damage</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - pathology</topic><topic>Hypertension, Renovascular - complications</topic><topic>Hypertension, Renovascular - pathology</topic><topic>Hypertrophy, Left Ventricular - complications</topic><topic>Hypertrophy, Left Ventricular - diagnosis</topic><topic>Hypertrophy, Left Ventricular - epidemiology</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - complications</topic><topic>Myocardial Ischemia - diagnosis</topic><topic>Myocardial Ischemia - epidemiology</topic><topic>Myocardium - pathology</topic><topic>Prevalence</topic><topic>Proteinuria - complications</topic><topic>Proteinuria - epidemiology</topic><topic>Radiography</topic><topic>Renal Artery Obstruction - complications</topic><topic>Renovascular hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Losito, Attilio</creatorcontrib><creatorcontrib>Fagugli, Riccardo Maria</creatorcontrib><creatorcontrib>Zampi, Ivano</creatorcontrib><creatorcontrib>Parente, Basso</creatorcontrib><creatorcontrib>de Rango, Paola</creatorcontrib><creatorcontrib>Giordano, Giuseppe</creatorcontrib><creatorcontrib>Cao, Piergiorgio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Losito, Attilio</au><au>Fagugli, Riccardo Maria</au><au>Zampi, Ivano</au><au>Parente, Basso</au><au>de Rango, Paola</au><au>Giordano, Giuseppe</au><au>Cao, Piergiorgio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Target Organ Damage in Renovascular and Essential Hypertension</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>9</volume><issue>11</issue><spage>1062</spage><epage>1067</epage><pages>1062-1067</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><abstract>In many reports, the prevalence of target organ damage in renovascular hypertension (RVH) appears to be higher than in essential hypertension (EH). Since in most studies the renal artery stenosis is part of a diffuse atherosclerotic disease, it is not known whether these complications are due to RVH itself or to the vascular disease.
We have undertaken a case control study of 92 patients divided into two groups (46 in each), one with RVH and the other with EH and abdominal aortic aneurysm, with a comparable degree of diffuse atherosclerotic vascular disease. The vascular state of the extracranial carotid arteries and abdominal and inferior limb districts was investigated with angiography and sonography. The prevalence of left ventricular hypertrophy (LVH) and ischemic heart disease (IHD) were assessed by electrocardiography. Serum creatinine and urinary protein excretion were employed in the renal evaluation. While the analysis of the results confirmed an even diffusion of atherosclerotic vascular disease between the two groups, a significant difference was found in the prevalence of heart and renal damage. LVH was present in 32.6% of RVH patients versus 10.8% in EH (
P = .02). Serum creatinine > 1.4 mg/dL was found in 50% of RVH and in 23.9% of EH, (
P = .01). The prevalence of proteinuria in RVH was also higher although not reaching the statistical significance. The results suggest that, in patients with comparable degrees of atherosclerotic vascular disease, RVH is responsible for the higher prevalence of target organ damage in this condition compared to those with EH. Am J Hypertens 1996;9:1062–1067</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8931830</pmid><doi>10.1016/0895-7061(96)00199-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of hypertension, 1996-11, Vol.9 (11), p.1062-1067 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Arterial hypertension. Arterial hypotension Arteriosclerosis - complications Arteriosclerosis - diagnostic imaging Arteriosclerosis - epidemiology atherosclerotic vascular disease Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Carotid Arteries - diagnostic imaging Case-Control Studies Clinical manifestations. Epidemiology. Investigative techniques. Etiology Creatinine - blood Cross-Sectional Studies Echocardiography, Doppler, Color Electrocardiography end-organ damage Female Humans Hypertension - complications Hypertension - pathology Hypertension, Renovascular - complications Hypertension, Renovascular - pathology Hypertrophy, Left Ventricular - complications Hypertrophy, Left Ventricular - diagnosis Hypertrophy, Left Ventricular - epidemiology Kidney - pathology Male Medical sciences Middle Aged Myocardial Ischemia - complications Myocardial Ischemia - diagnosis Myocardial Ischemia - epidemiology Myocardium - pathology Prevalence Proteinuria - complications Proteinuria - epidemiology Radiography Renal Artery Obstruction - complications Renovascular hypertension |
| title | Comparison of Target Organ Damage in Renovascular and Essential Hypertension |
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