Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome
We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 microgram/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the...
Gespeichert in:
| Veröffentlicht in: | Digestive diseases and sciences 1988-12, Vol.33 (12), p.1596-1600 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1600 |
|---|---|
| container_issue | 12 |
| container_start_page | 1596 |
| container_title | Digestive diseases and sciences |
| container_volume | 33 |
| creator | ERTAN, A OZDEN, A GOLODNER, E DEGERTEKIN, H ARIMURA, A |
| description | We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 microgram/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the gastric luminal SLI secretion in response to a gastric luminal acid perfusion in two patients with pernicious anemia. Our results have shown that: (1) pentagastrin caused a parallel increase in luminal hydrogen ions and SLI release in normal volunteers; (2) Zollinger-Ellison patients had elevated basal acid and SLI levels that did not increase further with pentagastrin; (3) pentagastrin did not increase gastric acid or luminal SLI secretion in pernicious anemia patients; and (4) in pernicious anemia patients, a gastric luminal acid perfusion caused a significant increase in gastric luminal SLI over baseline values. In conclusion, gastric luminal hydrochloric acid appears to be a factor which stimulates the secretion of luminal SLI in human beings. |
| doi_str_mv | 10.1007/BF01535952 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78559415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78559415</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-db494f6a1ea67e9b93e1da140e1bc753c68ea82ac61a9e2375df6a80d7e084ea3</originalsourceid><addsrcrecordid>eNpFkM9L9DAQhoMouq5evAs5iAehmmmapj1-yvoDBC968VJm06lfPtpkvySL7H9v1EVhYAaeh5fhZewExCUIoa-ubwUoqVpV7rAZKC2LUtXNLpsJqPMNUB-wwxj_CSFaDfU-2y9bUUlVztjmDmMK1vBxPVmHI49-wuRjwmQdj2QCJesd9wN3Pkw4Ro6u56uMyaXI3236y1cUnDXWrz8hTRa_nC_06sfRujcKxSIfMSfFjeuDn-iI7Q05jo63e85ebhfPN_fF49Pdw82fx8JIgFT0y6qthhqBsNbULltJ0CNUgmBptJKmbgibEk0N2FIpteqz3Yhek2gqQjln59-5q-D_rymmbrLR0DjmV_PHnW6Uaqvc35xdfIsm-BgDDd0q2AnDpgPRffbc_fac5dNt6no5Uf-jbovN_GzLMRoch4DO2PijaZB5pPwAWzuHnA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78559415</pqid></control><display><type>article</type><title>Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>ERTAN, A ; OZDEN, A ; GOLODNER, E ; DEGERTEKIN, H ; ARIMURA, A</creator><creatorcontrib>ERTAN, A ; OZDEN, A ; GOLODNER, E ; DEGERTEKIN, H ; ARIMURA, A</creatorcontrib><description>We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 microgram/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the gastric luminal SLI secretion in response to a gastric luminal acid perfusion in two patients with pernicious anemia. Our results have shown that: (1) pentagastrin caused a parallel increase in luminal hydrogen ions and SLI release in normal volunteers; (2) Zollinger-Ellison patients had elevated basal acid and SLI levels that did not increase further with pentagastrin; (3) pentagastrin did not increase gastric acid or luminal SLI secretion in pernicious anemia patients; and (4) in pernicious anemia patients, a gastric luminal acid perfusion caused a significant increase in gastric luminal SLI over baseline values. In conclusion, gastric luminal hydrochloric acid appears to be a factor which stimulates the secretion of luminal SLI in human beings.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF01535952</identifier><identifier>PMID: 2904352</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Anemia, Pernicious - metabolism ; Biological and medical sciences ; Female ; Gastric Acid - metabolism ; Gastric Mucosa - metabolism ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pentagastrin ; Somatostatin - metabolism ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Zollinger-Ellison Syndrome - metabolism</subject><ispartof>Digestive diseases and sciences, 1988-12, Vol.33 (12), p.1596-1600</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-db494f6a1ea67e9b93e1da140e1bc753c68ea82ac61a9e2375df6a80d7e084ea3</citedby><cites>FETCH-LOGICAL-c311t-db494f6a1ea67e9b93e1da140e1bc753c68ea82ac61a9e2375df6a80d7e084ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23911,23912,25120,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7137133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2904352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ERTAN, A</creatorcontrib><creatorcontrib>OZDEN, A</creatorcontrib><creatorcontrib>GOLODNER, E</creatorcontrib><creatorcontrib>DEGERTEKIN, H</creatorcontrib><creatorcontrib>ARIMURA, A</creatorcontrib><title>Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 microgram/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the gastric luminal SLI secretion in response to a gastric luminal acid perfusion in two patients with pernicious anemia. Our results have shown that: (1) pentagastrin caused a parallel increase in luminal hydrogen ions and SLI release in normal volunteers; (2) Zollinger-Ellison patients had elevated basal acid and SLI levels that did not increase further with pentagastrin; (3) pentagastrin did not increase gastric acid or luminal SLI secretion in pernicious anemia patients; and (4) in pernicious anemia patients, a gastric luminal acid perfusion caused a significant increase in gastric luminal SLI over baseline values. In conclusion, gastric luminal hydrochloric acid appears to be a factor which stimulates the secretion of luminal SLI in human beings.</description><subject>Adult</subject><subject>Anemia, Pernicious - metabolism</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pentagastrin</subject><subject>Somatostatin - metabolism</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Zollinger-Ellison Syndrome - metabolism</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9L9DAQhoMouq5evAs5iAehmmmapj1-yvoDBC968VJm06lfPtpkvySL7H9v1EVhYAaeh5fhZewExCUIoa-ubwUoqVpV7rAZKC2LUtXNLpsJqPMNUB-wwxj_CSFaDfU-2y9bUUlVztjmDmMK1vBxPVmHI49-wuRjwmQdj2QCJesd9wN3Pkw4Ro6u56uMyaXI3236y1cUnDXWrz8hTRa_nC_06sfRujcKxSIfMSfFjeuDn-iI7Q05jo63e85ebhfPN_fF49Pdw82fx8JIgFT0y6qthhqBsNbULltJ0CNUgmBptJKmbgibEk0N2FIpteqz3Yhek2gqQjln59-5q-D_rymmbrLR0DjmV_PHnW6Uaqvc35xdfIsm-BgDDd0q2AnDpgPRffbc_fac5dNt6no5Uf-jbovN_GzLMRoch4DO2PijaZB5pPwAWzuHnA</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>ERTAN, A</creator><creator>OZDEN, A</creator><creator>GOLODNER, E</creator><creator>DEGERTEKIN, H</creator><creator>ARIMURA, A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome</title><author>ERTAN, A ; OZDEN, A ; GOLODNER, E ; DEGERTEKIN, H ; ARIMURA, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-db494f6a1ea67e9b93e1da140e1bc753c68ea82ac61a9e2375df6a80d7e084ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Anemia, Pernicious - metabolism</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pentagastrin</topic><topic>Somatostatin - metabolism</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Zollinger-Ellison Syndrome - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ERTAN, A</creatorcontrib><creatorcontrib>OZDEN, A</creatorcontrib><creatorcontrib>GOLODNER, E</creatorcontrib><creatorcontrib>DEGERTEKIN, H</creatorcontrib><creatorcontrib>ARIMURA, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ERTAN, A</au><au>OZDEN, A</au><au>GOLODNER, E</au><au>DEGERTEKIN, H</au><au>ARIMURA, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>33</volume><issue>12</issue><spage>1596</spage><epage>1600</epage><pages>1596-1600</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>We studied the release of gastric luminal somatostatin-like immunoreactivity (SLI) in response to a pentagastrin infusion (0.9 microgram/kg/hr, intravenous) in five normal volunteers, five patients with pernicious anemia, and two patients with Zollinger-Ellison syndrome. In addition, we studied the gastric luminal SLI secretion in response to a gastric luminal acid perfusion in two patients with pernicious anemia. Our results have shown that: (1) pentagastrin caused a parallel increase in luminal hydrogen ions and SLI release in normal volunteers; (2) Zollinger-Ellison patients had elevated basal acid and SLI levels that did not increase further with pentagastrin; (3) pentagastrin did not increase gastric acid or luminal SLI secretion in pernicious anemia patients; and (4) in pernicious anemia patients, a gastric luminal acid perfusion caused a significant increase in gastric luminal SLI over baseline values. In conclusion, gastric luminal hydrochloric acid appears to be a factor which stimulates the secretion of luminal SLI in human beings.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>2904352</pmid><doi>10.1007/BF01535952</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 1988-12, Vol.33 (12), p.1596-1600 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78559415 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Anemia, Pernicious - metabolism Biological and medical sciences Female Gastric Acid - metabolism Gastric Mucosa - metabolism Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Other diseases. Semiology Pentagastrin Somatostatin - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Zollinger-Ellison Syndrome - metabolism |
| title | Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T00%3A13%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastric%20luminal%20somatostatin%20secretion%20of%20normals%20and%20patients%20with%20pernicious%20anemia%20and%20with%20Zollinger-Ellison%20syndrome&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=ERTAN,%20A&rft.date=1988-12-01&rft.volume=33&rft.issue=12&rft.spage=1596&rft.epage=1600&rft.pages=1596-1600&rft.issn=0163-2116&rft.eissn=1573-2568&rft.coden=DDSCDJ&rft_id=info:doi/10.1007/BF01535952&rft_dat=%3Cproquest_cross%3E78559415%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78559415&rft_id=info:pmid/2904352&rfr_iscdi=true |