Vinpocetine prevents ischemic cell damage in rat hippocampus
The effects of vinpocetine on hippocampal cell damage and local cerebral blood flow (LCBF) were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Duration of ischemia was 10 min. LCBF was determined after 2 min of recirculation using the 14C-iodoantipyrine technique...
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| Veröffentlicht in: | Life sciences (1973) 1988, Vol.43 (21), p.1733-1739 |
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| container_end_page | 1739 |
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| container_issue | 21 |
| container_start_page | 1733 |
| container_title | Life sciences (1973) |
| container_volume | 43 |
| creator | Sauer, Dirk Rischke, Ralf Beck, Thomas Roßberg, Christine Mennel, Hans-Dieter Bielenberg, Gerhard Wilhelm Krieglstein, Josef |
| description | The effects of vinpocetine on hippocampal cell damage and local cerebral blood flow (LCBF) were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Duration of ischemia was 10 min. LCBF was determined after 2 min of recirculation using the
14C-iodoantipyrine technique. Hippocampal cell loss was quantified histologically 7 days postischemia. Intraperitoneal application of vinpocetine (10 mg/kg) 15 min prior to ischemia significantly reduced neuronal cell loss in hippocampal CA 1 sector from 60 % to 28 %. The drug led to a marked increase in blood flow in cortical areas, whereas LCBF remained unchanged in hippocampus and all other structures measured. It is suggested that the protective effect of vinpocetine does not depend on increased postischemic blood flow. |
| doi_str_mv | 10.1016/0024-3205(88)90485-7 |
| format | Article |
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14C-iodoantipyrine technique. Hippocampal cell loss was quantified histologically 7 days postischemia. Intraperitoneal application of vinpocetine (10 mg/kg) 15 min prior to ischemia significantly reduced neuronal cell loss in hippocampal CA 1 sector from 60 % to 28 %. The drug led to a marked increase in blood flow in cortical areas, whereas LCBF remained unchanged in hippocampus and all other structures measured. It is suggested that the protective effect of vinpocetine does not depend on increased postischemic blood flow.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(88)90485-7</identifier><identifier>PMID: 3193857</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cardiovascular system ; Cerebrovascular Circulation - drug effects ; Disease Models, Animal ; Hippocampus - blood supply ; Hippocampus - drug effects ; Ischemic Attack, Transient - prevention & control ; Male ; Medical sciences ; Miscellaneous ; Organ Specificity ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Reference Values ; Vasodilator Agents - therapeutic use ; Vinca Alkaloids - pharmacology ; Vinca Alkaloids - therapeutic use</subject><ispartof>Life sciences (1973), 1988, Vol.43 (21), p.1733-1739</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-1d82370f8fa5fba7244bd99137cb2990a9b655054abceaee505ef2ba4a3136c3</citedby><cites>FETCH-LOGICAL-c417t-1d82370f8fa5fba7244bd99137cb2990a9b655054abceaee505ef2ba4a3136c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320588904857$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7116491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3193857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sauer, Dirk</creatorcontrib><creatorcontrib>Rischke, Ralf</creatorcontrib><creatorcontrib>Beck, Thomas</creatorcontrib><creatorcontrib>Roßberg, Christine</creatorcontrib><creatorcontrib>Mennel, Hans-Dieter</creatorcontrib><creatorcontrib>Bielenberg, Gerhard Wilhelm</creatorcontrib><creatorcontrib>Krieglstein, Josef</creatorcontrib><title>Vinpocetine prevents ischemic cell damage in rat hippocampus</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The effects of vinpocetine on hippocampal cell damage and local cerebral blood flow (LCBF) were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Duration of ischemia was 10 min. LCBF was determined after 2 min of recirculation using the
14C-iodoantipyrine technique. Hippocampal cell loss was quantified histologically 7 days postischemia. Intraperitoneal application of vinpocetine (10 mg/kg) 15 min prior to ischemia significantly reduced neuronal cell loss in hippocampal CA 1 sector from 60 % to 28 %. The drug led to a marked increase in blood flow in cortical areas, whereas LCBF remained unchanged in hippocampus and all other structures measured. It is suggested that the protective effect of vinpocetine does not depend on increased postischemic blood flow.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Disease Models, Animal</subject><subject>Hippocampus - blood supply</subject><subject>Hippocampus - drug effects</subject><subject>Ischemic Attack, Transient - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Organ Specificity</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Vinca Alkaloids - pharmacology</topic><topic>Vinca Alkaloids - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sauer, Dirk</creatorcontrib><creatorcontrib>Rischke, Ralf</creatorcontrib><creatorcontrib>Beck, Thomas</creatorcontrib><creatorcontrib>Roßberg, Christine</creatorcontrib><creatorcontrib>Mennel, Hans-Dieter</creatorcontrib><creatorcontrib>Bielenberg, Gerhard Wilhelm</creatorcontrib><creatorcontrib>Krieglstein, Josef</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauer, Dirk</au><au>Rischke, Ralf</au><au>Beck, Thomas</au><au>Roßberg, Christine</au><au>Mennel, Hans-Dieter</au><au>Bielenberg, Gerhard Wilhelm</au><au>Krieglstein, Josef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vinpocetine prevents ischemic cell damage in rat hippocampus</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1988</date><risdate>1988</risdate><volume>43</volume><issue>21</issue><spage>1733</spage><epage>1739</epage><pages>1733-1739</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>The effects of vinpocetine on hippocampal cell damage and local cerebral blood flow (LCBF) were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Duration of ischemia was 10 min. LCBF was determined after 2 min of recirculation using the
14C-iodoantipyrine technique. Hippocampal cell loss was quantified histologically 7 days postischemia. Intraperitoneal application of vinpocetine (10 mg/kg) 15 min prior to ischemia significantly reduced neuronal cell loss in hippocampal CA 1 sector from 60 % to 28 %. The drug led to a marked increase in blood flow in cortical areas, whereas LCBF remained unchanged in hippocampus and all other structures measured. It is suggested that the protective effect of vinpocetine does not depend on increased postischemic blood flow.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3193857</pmid><doi>10.1016/0024-3205(88)90485-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1988, Vol.43 (21), p.1733-1739 |
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| language | eng |
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| subjects | Animals Biological and medical sciences Cardiovascular system Cerebrovascular Circulation - drug effects Disease Models, Animal Hippocampus - blood supply Hippocampus - drug effects Ischemic Attack, Transient - prevention & control Male Medical sciences Miscellaneous Organ Specificity Pharmacology. Drug treatments Rats Rats, Inbred Strains Reference Values Vasodilator Agents - therapeutic use Vinca Alkaloids - pharmacology Vinca Alkaloids - therapeutic use |
| title | Vinpocetine prevents ischemic cell damage in rat hippocampus |
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