Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df ) has been positionally cloned, identifying a novel, tissue-specific, paired -like homeodomain transcription factor, termed Prophet of Pit-1 ( Prop-1 ). The df phenotype results from an appare...

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Veröffentlicht in:	Nature (London) 1996-11, Vol.384 (6607), p.327-333
Hauptverfasser:	Sornson, Mark W., Wu, Wei, Dasen, Jeremy S., Flynn, Sarah E., Norman, Deborah J., O'Connell, Shawn M., Gukovsky, Ilya, Carrière, Catherine, Ryan, Aimee K., Miller, Andrew P., Zuo, Lin, Gleiberman, Anatoli S., Andersen, Bogi, Beamer, Wes G., Rosenfeld, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Animals Biological and medical sciences Cell Lineage Classical genetics, quantitative genetics, hybrids DNA-Binding Proteins - genetics Dwarfism, Pituitary - embryology Dwarfism, Pituitary - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Genetics of eukaryotes. Biological and molecular evolution Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humanities and Social Sciences Hypothalamus - physiology Male Mice Mice, Inbred C57BL Molecular Sequence Data multidisciplinary Pituitary Gland, Anterior - abnormalities Pituitary Gland, Anterior - embryology Pituitary Gland, Anterior - physiology Point Mutation Science Science (multidisciplinary) Sequence Homology, Amino Acid Signal Transduction Thyroid Transcription Factor Pit-1 Transcription Factors - genetics Vertebrata
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