Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df ) has been positionally cloned, identifying a novel, tissue-specific, paired -like homeodomain transcription factor, termed Prophet of Pit-1 ( Prop-1 ). The df phenotype results from an appare...
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| Veröffentlicht in: | Nature (London) 1996-11, Vol.384 (6607), p.327-333 |
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| creator | Sornson, Mark W. Wu, Wei Dasen, Jeremy S. Flynn, Sarah E. Norman, Deborah J. O'Connell, Shawn M. Gukovsky, Ilya Carrière, Catherine Ryan, Aimee K. Miller, Andrew P. Zuo, Lin Gleiberman, Anatoli S. Andersen, Bogi Beamer, Wes G. Rosenfeld, Michael G. |
| description | The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf,
df
) has been positionally cloned, identifying a novel, tissue-specific,
paired
-like homeodomain transcription factor, termed
Prophet
of
Pit-1
(
Prop-1
). The
df
phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate
Pit-1
gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis. |
| doi_str_mv | 10.1038/384327a0 |
| format | Article |
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df
) has been positionally cloned, identifying a novel, tissue-specific,
paired
-like homeodomain transcription factor, termed
Prophet
of
Pit-1
(
Prop-1
). The
df
phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate
Pit-1
gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/384327a0</identifier><identifier>PMID: 8934515</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alleles ; Amino Acid Sequence ; Animals ; Biological and medical sciences ; Cell Lineage ; Classical genetics, quantitative genetics, hybrids ; DNA-Binding Proteins - genetics ; Dwarfism, Pituitary - embryology ; Dwarfism, Pituitary - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Genetics of eukaryotes. Biological and molecular evolution ; Homeodomain Proteins - genetics ; Homeodomain Proteins - physiology ; Humanities and Social Sciences ; Hypothalamus - physiology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; multidisciplinary ; Pituitary Gland, Anterior - abnormalities ; Pituitary Gland, Anterior - embryology ; Pituitary Gland, Anterior - physiology ; Point Mutation ; Science ; Science (multidisciplinary) ; Sequence Homology, Amino Acid ; Signal Transduction ; Thyroid ; Transcription Factor Pit-1 ; Transcription Factors - genetics ; Vertebrata</subject><ispartof>Nature (London), 1996-11, Vol.384 (6607), p.327-333</ispartof><rights>Springer Nature Limited 1996</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Nov 28, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-1956e330ebbd73ed752d793dc3266da531d27f8effaf7c3ad20bfd18096ccff63</citedby><cites>FETCH-LOGICAL-c499t-1956e330ebbd73ed752d793dc3266da531d27f8effaf7c3ad20bfd18096ccff63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/384327a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/384327a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2489529$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8934515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sornson, Mark W.</creatorcontrib><creatorcontrib>Wu, Wei</creatorcontrib><creatorcontrib>Dasen, Jeremy S.</creatorcontrib><creatorcontrib>Flynn, Sarah E.</creatorcontrib><creatorcontrib>Norman, Deborah J.</creatorcontrib><creatorcontrib>O'Connell, Shawn M.</creatorcontrib><creatorcontrib>Gukovsky, Ilya</creatorcontrib><creatorcontrib>Carrière, Catherine</creatorcontrib><creatorcontrib>Ryan, Aimee K.</creatorcontrib><creatorcontrib>Miller, Andrew P.</creatorcontrib><creatorcontrib>Zuo, Lin</creatorcontrib><creatorcontrib>Gleiberman, Anatoli S.</creatorcontrib><creatorcontrib>Andersen, Bogi</creatorcontrib><creatorcontrib>Beamer, Wes G.</creatorcontrib><creatorcontrib>Rosenfeld, Michael G.</creatorcontrib><title>Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf,
df
) has been positionally cloned, identifying a novel, tissue-specific,
paired
-like homeodomain transcription factor, termed
Prophet
of
Pit-1
(
Prop-1
). The
df
phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate
Pit-1
gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.</description><subject>Alleles</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Lineage</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Dwarfism, Pituitary - embryology</subject><subject>Dwarfism, Pituitary - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - physiology</subject><subject>Humanities and Social Sciences</subject><subject>Hypothalamus - physiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Pituitary Gland, Anterior - abnormalities</subject><subject>Pituitary Gland, Anterior - embryology</subject><subject>Pituitary Gland, Anterior - physiology</subject><subject>Point Mutation</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction</subject><subject>Thyroid</subject><subject>Transcription Factor Pit-1</subject><subject>Transcription Factors - genetics</subject><subject>Vertebrata</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkVtrFTEUhYMo9bQK_gEhiHh5GE0m98dS6gUK9kGfh0yy05MyMzkmmUr_vSnnWEFBnzbs9e21k70QekbJO0qYfs80Z72y5AHaUK5kx6VWD9GGkF53RDP5GB2Xck0IEVTxI3SkDeOCig2Cy1jXWG2-xVNcwF4B9lAhz3GxNaYFj7e4bgFf5rTbQsUp4DbRUbxNMySfZhsXHKyrKbfBAK7GG8CtdzpDwf6HzSGW-Ql6FOxU4OmhnqBvH86_nn3qLr58_Hx2etE5bkxzNUICYwTG0SsGXoneK8O8Y72U3gpGfa-ChhBsUI5Z35MxeKqJkc6FINkJerX33eX0fYVShzkWB9NkF0hrGZQWgjIhGvj63yBnzBjZbvs_SyqkoYypBr74A7xOa17ad4eecM6N5qZBb_aQy6mUDGHY5Ti36w-UDHdJDr-SbOjzg986zuDvwUN0TX950G1xdgrZLi6We6zn2oj-buPbPVaaslxB_v2sv1b-BBwzshw</recordid><startdate>19961128</startdate><enddate>19961128</enddate><creator>Sornson, Mark W.</creator><creator>Wu, Wei</creator><creator>Dasen, Jeremy S.</creator><creator>Flynn, Sarah E.</creator><creator>Norman, Deborah J.</creator><creator>O'Connell, Shawn M.</creator><creator>Gukovsky, Ilya</creator><creator>Carrière, Catherine</creator><creator>Ryan, Aimee K.</creator><creator>Miller, Andrew P.</creator><creator>Zuo, Lin</creator><creator>Gleiberman, Anatoli S.</creator><creator>Andersen, Bogi</creator><creator>Beamer, Wes G.</creator><creator>Rosenfeld, Michael G.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19961128</creationdate><title>Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism</title><author>Sornson, Mark W. ; Wu, Wei ; Dasen, Jeremy S. ; Flynn, Sarah E. ; Norman, Deborah J. ; O'Connell, Shawn M. ; Gukovsky, Ilya ; Carrière, Catherine ; Ryan, Aimee K. ; Miller, Andrew P. ; Zuo, Lin ; Gleiberman, Anatoli S. ; Andersen, Bogi ; Beamer, Wes G. ; Rosenfeld, Michael G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-1956e330ebbd73ed752d793dc3266da531d27f8effaf7c3ad20bfd18096ccff63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alleles</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Lineage</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Dwarfism, Pituitary - embryology</topic><topic>Dwarfism, Pituitary - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - physiology</topic><topic>Humanities and Social Sciences</topic><topic>Hypothalamus - physiology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Pituitary Gland, Anterior - abnormalities</topic><topic>Pituitary Gland, Anterior - embryology</topic><topic>Pituitary Gland, Anterior - physiology</topic><topic>Point Mutation</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sequence Homology, Amino Acid</topic><topic>Signal Transduction</topic><topic>Thyroid</topic><topic>Transcription Factor Pit-1</topic><topic>Transcription Factors - genetics</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sornson, Mark W.</creatorcontrib><creatorcontrib>Wu, 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sornson, Mark W.</au><au>Wu, Wei</au><au>Dasen, Jeremy S.</au><au>Flynn, Sarah E.</au><au>Norman, Deborah J.</au><au>O'Connell, Shawn M.</au><au>Gukovsky, Ilya</au><au>Carrière, Catherine</au><au>Ryan, Aimee K.</au><au>Miller, Andrew P.</au><au>Zuo, Lin</au><au>Gleiberman, Anatoli S.</au><au>Andersen, Bogi</au><au>Beamer, Wes G.</au><au>Rosenfeld, Michael G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1996-11-28</date><risdate>1996</risdate><volume>384</volume><issue>6607</issue><spage>327</spage><epage>333</epage><pages>327-333</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf,
df
) has been positionally cloned, identifying a novel, tissue-specific,
paired
-like homeodomain transcription factor, termed
Prophet
of
Pit-1
(
Prop-1
). The
df
phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate
Pit-1
gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8934515</pmid><doi>10.1038/384327a0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1996-11, Vol.384 (6607), p.327-333 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78551355 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Alleles Amino Acid Sequence Animals Biological and medical sciences Cell Lineage Classical genetics, quantitative genetics, hybrids DNA-Binding Proteins - genetics Dwarfism, Pituitary - embryology Dwarfism, Pituitary - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Genetics of eukaryotes. Biological and molecular evolution Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humanities and Social Sciences Hypothalamus - physiology Male Mice Mice, Inbred C57BL Molecular Sequence Data multidisciplinary Pituitary Gland, Anterior - abnormalities Pituitary Gland, Anterior - embryology Pituitary Gland, Anterior - physiology Point Mutation Science Science (multidisciplinary) Sequence Homology, Amino Acid Signal Transduction Thyroid Transcription Factor Pit-1 Transcription Factors - genetics Vertebrata |
| title | Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism |
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