Suppression of monosodium urate crystal—induced acute inflammation by diets enriched with gamma‐linolenic acid and eicosapentaenoic acid
A subcutaneous air pouch formed in Sprague‐Dawley rats was used to study the effect of diets enriched in γ‐linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals. The GLA‐enriched diet suppressed significantly...
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| Veröffentlicht in: | Arthritis and rheumatism 1988-12, Vol.31 (12), p.1543-1551 |
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| container_title | Arthritis and rheumatism |
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| creator | Tate, Guillermo A. Mandell, Brian F. Karmali, Rashida A. Laposata, Michael Baker, Daniel G. Schumacher, H. Ralph Zurier, Robert B. |
| description | A subcutaneous air pouch formed in Sprague‐Dawley rats was used to study the effect of diets enriched in γ‐linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals. The GLA‐enriched diet suppressed significantly the cellular phase of inflammation (polymorphonuclear leukocyte accumulation, crystal phagocytosis, and lysosomal enzyme activity), but it had little effect on the fluid phase (exudate volume and protein concentration). In contrast, the EPA‐enriched diet suppressed the fluid phase but not the cellular phase of inflammation. The findings indicate that the fluid and cellular phases of acute inflammation can be controlled independently. A combined diet of fish oil and plant seed oil (EPA‐enriched and GLA‐enriched) reduced both the cellular and fluid phases of inflammation. Thus, dietary provision of alternative substrates for oxidative metabolism (other than arachidonic acid) modifies monosodium urate crystal‐induced acute inflammation. |
| doi_str_mv | 10.1002/art.1780311211 |
| format | Article |
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Ralph ; Zurier, Robert B.</creator><creatorcontrib>Tate, Guillermo A. ; Mandell, Brian F. ; Karmali, Rashida A. ; Laposata, Michael ; Baker, Daniel G. ; Schumacher, H. Ralph ; Zurier, Robert B.</creatorcontrib><description>A subcutaneous air pouch formed in Sprague‐Dawley rats was used to study the effect of diets enriched in γ‐linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals. The GLA‐enriched diet suppressed significantly the cellular phase of inflammation (polymorphonuclear leukocyte accumulation, crystal phagocytosis, and lysosomal enzyme activity), but it had little effect on the fluid phase (exudate volume and protein concentration). In contrast, the EPA‐enriched diet suppressed the fluid phase but not the cellular phase of inflammation. The findings indicate that the fluid and cellular phases of acute inflammation can be controlled independently. A combined diet of fish oil and plant seed oil (EPA‐enriched and GLA‐enriched) reduced both the cellular and fluid phases of inflammation. Thus, dietary provision of alternative substrates for oxidative metabolism (other than arachidonic acid) modifies monosodium urate crystal‐induced acute inflammation.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780311211</identifier><identifier>PMID: 2848532</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biological and medical sciences ; Dietary Fats, Unsaturated - therapeutic use ; Dinoprostone - metabolism ; Diseases of the osteoarticular system ; Eicosapentaenoic Acid - therapeutic use ; Fatty Acids - blood ; Fatty Acids - metabolism ; Fatty Acids, Essential - therapeutic use ; Female ; Fish Oils - therapeutic use ; gamma-Linolenic Acid ; Inflammation - chemically induced ; Inflammation - diet therapy ; Inflammation - metabolism ; Inflammation - pathology ; Linoleic Acids ; Linolenic Acids - therapeutic use ; Male ; Medical sciences ; Miscellaneous. Osteoarticular involvement in other diseases ; Phagocytosis ; Plant Oils ; Rats ; Rats, Inbred Strains ; Uric Acid</subject><ispartof>Arthritis and rheumatism, 1988-12, Vol.31 (12), p.1543-1551</ispartof><rights>Copyright © 1988 American College of Rheumatology</rights><rights>1989 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3691-a2fe33e729e74bbeb45c1bcbd26d3874d4f513e38df0eb6e4ca5aecadea650a03</citedby><cites>FETCH-LOGICAL-c3691-a2fe33e729e74bbeb45c1bcbd26d3874d4f513e38df0eb6e4ca5aecadea650a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780311211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780311211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7301565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2848532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tate, Guillermo A.</creatorcontrib><creatorcontrib>Mandell, Brian F.</creatorcontrib><creatorcontrib>Karmali, Rashida A.</creatorcontrib><creatorcontrib>Laposata, Michael</creatorcontrib><creatorcontrib>Baker, Daniel G.</creatorcontrib><creatorcontrib>Schumacher, H. Ralph</creatorcontrib><creatorcontrib>Zurier, Robert B.</creatorcontrib><title>Suppression of monosodium urate crystal—induced acute inflammation by diets enriched with gamma‐linolenic acid and eicosapentaenoic acid</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>A subcutaneous air pouch formed in Sprague‐Dawley rats was used to study the effect of diets enriched in γ‐linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals. The GLA‐enriched diet suppressed significantly the cellular phase of inflammation (polymorphonuclear leukocyte accumulation, crystal phagocytosis, and lysosomal enzyme activity), but it had little effect on the fluid phase (exudate volume and protein concentration). In contrast, the EPA‐enriched diet suppressed the fluid phase but not the cellular phase of inflammation. The findings indicate that the fluid and cellular phases of acute inflammation can be controlled independently. A combined diet of fish oil and plant seed oil (EPA‐enriched and GLA‐enriched) reduced both the cellular and fluid phases of inflammation. Thus, dietary provision of alternative substrates for oxidative metabolism (other than arachidonic acid) modifies monosodium urate crystal‐induced acute inflammation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dietary Fats, Unsaturated - therapeutic use</subject><subject>Dinoprostone - metabolism</subject><subject>Diseases of the osteoarticular system</subject><subject>Eicosapentaenoic Acid - therapeutic use</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids, Essential - therapeutic use</subject><subject>Female</subject><subject>Fish Oils - therapeutic use</subject><subject>gamma-Linolenic Acid</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - diet therapy</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Linoleic Acids</subject><subject>Linolenic Acids - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Phagocytosis</subject><subject>Plant Oils</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Uric Acid</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1u1TAQhS0EKpfClh2SF6i73Ponzs-yqgpFqoRUyjqa2BNq5NjBTlTdXR-ARRc8YZ-kvrpRYcdq5DnfOWMdQt5ztuWMiVOI85bXDZOcC85fkA1Xoi0Yl_wl2TDGykKqlr8mb1L6mZ9CKnlEjkRTNkqKDfn9bZmmiCnZ4GkY6Bh8SMHYZaRLhBmpjrs0g3u8_2O9WTQaCnrJe-sHB-MI897Y76ixOCeKPlp9m6E7O9_SH3vg8f7BWR8cequz1-YAbyhaHRJM6GdAH1blLXk1gEv4bp3H5Puni5vzy-Lq6-cv52dXhZZVywsQA0qJtWixLvse-1Jp3uveiMrIpi5NOSguUTZmYNhXWGpQgBoMQqUYMHlMTg65Uwy_FkxzN9qk0TnwGJbU1Y0qW67aDG4PoI4hpYhDN0U7Qtx1nHX7-rtcf_e3_mz4sCYv_YjmGV_7zvrHVYekwQ0RvLbpGasl46pSGWsP2J11uPvP0e7s-uafLzwBnyakrw</recordid><startdate>198812</startdate><enddate>198812</enddate><creator>Tate, Guillermo A.</creator><creator>Mandell, Brian F.</creator><creator>Karmali, Rashida A.</creator><creator>Laposata, Michael</creator><creator>Baker, Daniel G.</creator><creator>Schumacher, H. Ralph</creator><creator>Zurier, Robert B.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198812</creationdate><title>Suppression of monosodium urate crystal—induced acute inflammation by diets enriched with gamma‐linolenic acid and eicosapentaenoic acid</title><author>Tate, Guillermo A. ; Mandell, Brian F. ; Karmali, Rashida A. ; Laposata, Michael ; Baker, Daniel G. ; Schumacher, H. 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Ralph</au><au>Zurier, Robert B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of monosodium urate crystal—induced acute inflammation by diets enriched with gamma‐linolenic acid and eicosapentaenoic acid</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1988-12</date><risdate>1988</risdate><volume>31</volume><issue>12</issue><spage>1543</spage><epage>1551</epage><pages>1543-1551</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>A subcutaneous air pouch formed in Sprague‐Dawley rats was used to study the effect of diets enriched in γ‐linolenic acid (GLA) (in plant seed oil) and eicosapentaenoic acid (EPA) (in fish oil) on acute inflammation induced by monosodium urate crystals. The GLA‐enriched diet suppressed significantly the cellular phase of inflammation (polymorphonuclear leukocyte accumulation, crystal phagocytosis, and lysosomal enzyme activity), but it had little effect on the fluid phase (exudate volume and protein concentration). In contrast, the EPA‐enriched diet suppressed the fluid phase but not the cellular phase of inflammation. The findings indicate that the fluid and cellular phases of acute inflammation can be controlled independently. A combined diet of fish oil and plant seed oil (EPA‐enriched and GLA‐enriched) reduced both the cellular and fluid phases of inflammation. Thus, dietary provision of alternative substrates for oxidative metabolism (other than arachidonic acid) modifies monosodium urate crystal‐induced acute inflammation.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>2848532</pmid><doi>10.1002/art.1780311211</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Dietary Fats, Unsaturated - therapeutic use Dinoprostone - metabolism Diseases of the osteoarticular system Eicosapentaenoic Acid - therapeutic use Fatty Acids - blood Fatty Acids - metabolism Fatty Acids, Essential - therapeutic use Female Fish Oils - therapeutic use gamma-Linolenic Acid Inflammation - chemically induced Inflammation - diet therapy Inflammation - metabolism Inflammation - pathology Linoleic Acids Linolenic Acids - therapeutic use Male Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Phagocytosis Plant Oils Rats Rats, Inbred Strains Uric Acid |
| title | Suppression of monosodium urate crystal—induced acute inflammation by diets enriched with gamma‐linolenic acid and eicosapentaenoic acid |
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