Plasma and platelet von Willebrand factor defects in uremia

Several mechanisms have been proposed to explain the prolonged bleeding times and clinical bleeding in chronic renal failure. Recent evidence has implicated an abnormality in the structure or function of the von Willebrand factor or in its interaction with uremic platelets. We investigated this fact...

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Veröffentlicht in:	The American journal of medicine 1988-12, Vol.85 (6), p.806-810
Hauptverfasser:	Gralnick, Harvey R., McKeown, Laurie P., Williams, Sybil B., Shafer, Brenda C., Pierce, Leslie
Format:	Artikel
Sprache:	eng
Schlagworte:	Bleeding Time Blood Platelets - metabolism Chromatography, Agarose Humans Kidney Failure, Chronic - blood Molecular Weight Platelet Aggregation - drug effects Platelet Count Protein Binding - drug effects Ristocetin - pharmacology Uremia - blood von Willebrand Factor - analysis von Willebrand Factor - metabolism
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