Smoking impairs alveolar macrophage activation after inert dust exposure
Magnetopneumography was applied to investigate intracellular phagosome motion in alveolar macrophage cells of healthy subjects (non-smokers and smokers). Ingested magnetic microparticles are inhaled and phagocytized by alveolar macrophages within hours. Thereby the particles are transferred into pha...
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| Veröffentlicht in: | Toxicology letters 1996-11, Vol.88 (1), p.131-137 |
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| container_title | Toxicology letters |
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| creator | Möller, W. Barth, W. Pohlit, W. Rust, M. Siekmeier, R. Stahlhofen, W. Heyder, J. |
| description | Magnetopneumography was applied to investigate intracellular phagosome motion in alveolar macrophage cells of healthy subjects (non-smokers and smokers). Ingested magnetic microparticles are inhaled and phagocytized by alveolar macrophages within hours. Thereby the particles are transferred into phagolysosomes. After magnetization the particles produce a macroscopic magnetic field of the lungs. Cellular motility causes a decay of the field (relaxation) by stochastic disorientation of the dipole particles (phagolysosomes) in the cells. Our studies have shown that the deposition of magnetite test particles induces a non-specific activation of the macrophage cells with a faster relaxation. This activation vanishes within the first day after particle deposition. This macrophage activation due to dust exposure was not present in smokers. It follows that cigarette smoking either causes a damage of the cellular defense or causes an adaptation of the macrophage cells to the permanent cigarette smoke inhalation. |
| doi_str_mv | 10.1016/0378-4274(96)03728-9 |
| format | Article |
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Ingested magnetic microparticles are inhaled and phagocytized by alveolar macrophages within hours. Thereby the particles are transferred into phagolysosomes. After magnetization the particles produce a macroscopic magnetic field of the lungs. Cellular motility causes a decay of the field (relaxation) by stochastic disorientation of the dipole particles (phagolysosomes) in the cells. Our studies have shown that the deposition of magnetite test particles induces a non-specific activation of the macrophage cells with a faster relaxation. This activation vanishes within the first day after particle deposition. This macrophage activation due to dust exposure was not present in smokers. It follows that cigarette smoking either causes a damage of the cellular defense or causes an adaptation of the macrophage cells to the permanent cigarette smoke inhalation.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(96)03728-9</identifier><identifier>PMID: 8920727</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Activation ; Administration, Inhalation ; Biological and medical sciences ; Cell Movement - drug effects ; Dust - adverse effects ; Ferric Compounds - administration & dosage ; Human macrophages ; Humans ; Lung - cytology ; Lung - physiology ; Macrophage Activation - physiology ; Macrophages, Alveolar - drug effects ; Macrophages, Alveolar - physiology ; Magnetics ; Magnetopneumography ; Medical sciences ; Phagosome motion ; Phagosomes - drug effects ; Phagosomes - physiology ; Smoking - adverse effects ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Toxicology letters, 1996-11, Vol.88 (1), p.131-137</ispartof><rights>1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-31b986567e7c596c5823293894cf9977eeae61583f9a05cd6f5c661b6c485d263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(96)03728-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2472909$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8920727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alink, GM (eds)</contributor><contributor>Seemayer, NH</contributor><contributor>Hadnagy, W</contributor><creatorcontrib>Möller, W.</creatorcontrib><creatorcontrib>Barth, W.</creatorcontrib><creatorcontrib>Pohlit, W.</creatorcontrib><creatorcontrib>Rust, M.</creatorcontrib><creatorcontrib>Siekmeier, R.</creatorcontrib><creatorcontrib>Stahlhofen, W.</creatorcontrib><creatorcontrib>Heyder, J.</creatorcontrib><title>Smoking impairs alveolar macrophage activation after inert dust exposure</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Magnetopneumography was applied to investigate intracellular phagosome motion in alveolar macrophage cells of healthy subjects (non-smokers and smokers). Ingested magnetic microparticles are inhaled and phagocytized by alveolar macrophages within hours. Thereby the particles are transferred into phagolysosomes. After magnetization the particles produce a macroscopic magnetic field of the lungs. Cellular motility causes a decay of the field (relaxation) by stochastic disorientation of the dipole particles (phagolysosomes) in the cells. Our studies have shown that the deposition of magnetite test particles induces a non-specific activation of the macrophage cells with a faster relaxation. This activation vanishes within the first day after particle deposition. This macrophage activation due to dust exposure was not present in smokers. It follows that cigarette smoking either causes a damage of the cellular defense or causes an adaptation of the macrophage cells to the permanent cigarette smoke inhalation.</description><subject>Activation</subject><subject>Administration, Inhalation</subject><subject>Biological and medical sciences</subject><subject>Cell Movement - drug effects</subject><subject>Dust - adverse effects</subject><subject>Ferric Compounds - administration & dosage</subject><subject>Human macrophages</subject><subject>Humans</subject><subject>Lung - cytology</subject><subject>Lung - physiology</subject><subject>Macrophage Activation - physiology</subject><subject>Macrophages, Alveolar - drug effects</subject><subject>Macrophages, Alveolar - physiology</subject><subject>Magnetics</subject><subject>Magnetopneumography</subject><subject>Medical sciences</subject><subject>Phagosome motion</subject><subject>Phagosomes - drug effects</subject><subject>Phagosomes - physiology</subject><subject>Smoking - adverse effects</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6DxR6ENFDNU2br4sgi1-w4EE9h2w6XaP9MmkX_fembtmjnsIwzzuZeRA6TvBlghN2hVMu4ozw7Fyyi1AQEcsdNE0El3GaMLmLpltkHx14_44xZhmjEzQRkmBO-BQ9PFfNh61Xka1abZ2PdLmGptQuqrRxTfumVxBp09m17mxTR7rowEW2BtdFee-7CL7axvcODtFeoUsPR-M7Q693ty_zh3jxdP84v1nEJhNpFxZbSsEo48ANlcxQQVIiUyEzU0jJOYAGllCRFlJjanJWUMNYsmQhTnPC0hk628xtXfPZg-9UZb2BstQ1NL1XXNBMEEn-BcMnNAjBAcw2YLjXeweFap2ttPtWCVaDaTVoVINGJX8LIpQMsZNxfr-sIN-GRrWhfzr2tTe6LJyujfVbjGScSDyMud5gEKStLTjljYXaQG4dmE7ljf17jx-87plP</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Möller, W.</creator><creator>Barth, W.</creator><creator>Pohlit, W.</creator><creator>Rust, M.</creator><creator>Siekmeier, R.</creator><creator>Stahlhofen, W.</creator><creator>Heyder, J.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Smoking impairs alveolar macrophage activation after inert dust exposure</title><author>Möller, W. ; Barth, W. ; Pohlit, W. ; Rust, M. ; Siekmeier, R. ; Stahlhofen, W. ; Heyder, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-31b986567e7c596c5823293894cf9977eeae61583f9a05cd6f5c661b6c485d263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Activation</topic><topic>Administration, Inhalation</topic><topic>Biological and medical sciences</topic><topic>Cell Movement - drug effects</topic><topic>Dust - adverse effects</topic><topic>Ferric Compounds - administration & dosage</topic><topic>Human macrophages</topic><topic>Humans</topic><topic>Lung - cytology</topic><topic>Lung - physiology</topic><topic>Macrophage Activation - physiology</topic><topic>Macrophages, Alveolar - drug effects</topic><topic>Macrophages, Alveolar - physiology</topic><topic>Magnetics</topic><topic>Magnetopneumography</topic><topic>Medical sciences</topic><topic>Phagosome motion</topic><topic>Phagosomes - drug effects</topic><topic>Phagosomes - physiology</topic><topic>Smoking - adverse effects</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Möller, W.</creatorcontrib><creatorcontrib>Barth, W.</creatorcontrib><creatorcontrib>Pohlit, W.</creatorcontrib><creatorcontrib>Rust, M.</creatorcontrib><creatorcontrib>Siekmeier, R.</creatorcontrib><creatorcontrib>Stahlhofen, W.</creatorcontrib><creatorcontrib>Heyder, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Möller, W.</au><au>Barth, W.</au><au>Pohlit, W.</au><au>Rust, M.</au><au>Siekmeier, R.</au><au>Stahlhofen, W.</au><au>Heyder, J.</au><au>Alink, GM (eds)</au><au>Seemayer, NH</au><au>Hadnagy, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smoking impairs alveolar macrophage activation after inert dust exposure</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>88</volume><issue>1</issue><spage>131</spage><epage>137</epage><pages>131-137</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Magnetopneumography was applied to investigate intracellular phagosome motion in alveolar macrophage cells of healthy subjects (non-smokers and smokers). Ingested magnetic microparticles are inhaled and phagocytized by alveolar macrophages within hours. Thereby the particles are transferred into phagolysosomes. After magnetization the particles produce a macroscopic magnetic field of the lungs. Cellular motility causes a decay of the field (relaxation) by stochastic disorientation of the dipole particles (phagolysosomes) in the cells. Our studies have shown that the deposition of magnetite test particles induces a non-specific activation of the macrophage cells with a faster relaxation. This activation vanishes within the first day after particle deposition. This macrophage activation due to dust exposure was not present in smokers. It follows that cigarette smoking either causes a damage of the cellular defense or causes an adaptation of the macrophage cells to the permanent cigarette smoke inhalation.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>8920727</pmid><doi>10.1016/0378-4274(96)03728-9</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1996-11, Vol.88 (1), p.131-137 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Activation Administration, Inhalation Biological and medical sciences Cell Movement - drug effects Dust - adverse effects Ferric Compounds - administration & dosage Human macrophages Humans Lung - cytology Lung - physiology Macrophage Activation - physiology Macrophages, Alveolar - drug effects Macrophages, Alveolar - physiology Magnetics Magnetopneumography Medical sciences Phagosome motion Phagosomes - drug effects Phagosomes - physiology Smoking - adverse effects Tobacco, tobacco smoking Toxicology |
| title | Smoking impairs alveolar macrophage activation after inert dust exposure |
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