Histochemical localization of acetylcholinesterase in the cerebral ganglia of Fasciola hepatica, a parasitic flatworm
Acetylcholinesterase activity was found in the cell bodies and extracellularly in the neuropile of the cerebral ganglia of the adult trematode parasite, Fasciola hepatica. Within neuronal cell bodies of the cerebral ganglion, acetylcholinesterase reaction product was found in the endoplasmic reticul...
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| Veröffentlicht in: | The Journal of parasitology 1988-12, Vol.74 (6), p.1023-1032 |
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| container_title | The Journal of parasitology |
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| creator | Sukhdeo, S.C Sukhdeo, M.V.K Mettrick, D.F |
| description | Acetylcholinesterase activity was found in the cell bodies and extracellularly in the neuropile of the cerebral ganglia of the adult trematode parasite, Fasciola hepatica. Within neuronal cell bodies of the cerebral ganglion, acetylcholinesterase reaction product was found in the endoplasmic reticulum, in the cisternae of the Golgi apparatus, and in secretory vesicles near the inner (releasing face) cisternae. Acetylcholinesterase reaction product was not seen intracellularly within any nerve processes. The reaction product was found around the somatic cell membranes and in the extracellular space between closely apposed nerve processes in the neuropile. Acetylcholinesterase reaction product was associated with synaptic endings that contained clear spheroidal synaptic vesicles, and the reaction product was localized at the site of synaptic contact between the zone of apposition of the pre- and postsynaptic terminals. This intracellular and extracellular distribution of the enzyme is consistent with its function as the degrading enzyme in cholinergic transmission. |
| doi_str_mv | 10.2307/3282227 |
| format | Article |
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Within neuronal cell bodies of the cerebral ganglion, acetylcholinesterase reaction product was found in the endoplasmic reticulum, in the cisternae of the Golgi apparatus, and in secretory vesicles near the inner (releasing face) cisternae. Acetylcholinesterase reaction product was not seen intracellularly within any nerve processes. The reaction product was found around the somatic cell membranes and in the extracellular space between closely apposed nerve processes in the neuropile. Acetylcholinesterase reaction product was associated with synaptic endings that contained clear spheroidal synaptic vesicles, and the reaction product was localized at the site of synaptic contact between the zone of apposition of the pre- and postsynaptic terminals. This intracellular and extracellular distribution of the enzyme is consistent with its function as the degrading enzyme in cholinergic transmission.</description><identifier>ISSN: 0022-3395</identifier><identifier>EISSN: 1937-2345</identifier><identifier>DOI: 10.2307/3282227</identifier><identifier>PMID: 3193324</identifier><identifier>CODEN: JOPAA2</identifier><language>eng</language><publisher>Lawrence, KS: American Society of Parasitologists</publisher><subject>ACETILCOLINESTERASA ; ACETYLCHOLINESTERASE ; Acetylcholinesterase - analysis ; Animals ; Biological and medical sciences ; BRAIN ; Cell Membrane - enzymology ; Cell Nucleus - enzymology ; CEREBRO ; Cholinergic receptors ; ENCEPHALE ; Endoplasmic Reticulum - enzymology ; FASCIOLA ; Fasciola hepatica ; Fasciola hepatica - enzymology ; Fundamental and applied biological sciences. Psychology ; GANGLIA ; GANGLION NERVEUX ; GANGLIOS ; Golgi Apparatus - enzymology ; HISTOCHEMISTRY ; Invertebrates ; Microscopy, Electron ; Nemathelminthia. Plathelmintha ; Nerves ; Nervous System - enzymology ; Neurons ; Neurons - enzymology ; Neurons - ultrastructure ; Neuropil ; Neurotransmitters ; Pain ; Parasitology ; RAT ; RATA ; RATS ; Reaction products ; Synapses ; Synapses - enzymology ; Ultrastructure</subject><ispartof>The Journal of parasitology, 1988-12, Vol.74 (6), p.1023-1032</ispartof><rights>Copyright 1988 American Society of Parasitologists</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-a741559c71cacd4e03043d0908762e4785353950e78a1b1e261ad4360756f25a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3282227$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3282227$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27926,27927,58019,58252</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7348845$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3193324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sukhdeo, S.C</creatorcontrib><creatorcontrib>Sukhdeo, M.V.K</creatorcontrib><creatorcontrib>Mettrick, D.F</creatorcontrib><title>Histochemical localization of acetylcholinesterase in the cerebral ganglia of Fasciola hepatica, a parasitic flatworm</title><title>The Journal of parasitology</title><addtitle>J Parasitol</addtitle><description>Acetylcholinesterase activity was found in the cell bodies and extracellularly in the neuropile of the cerebral ganglia of the adult trematode parasite, Fasciola hepatica. Within neuronal cell bodies of the cerebral ganglion, acetylcholinesterase reaction product was found in the endoplasmic reticulum, in the cisternae of the Golgi apparatus, and in secretory vesicles near the inner (releasing face) cisternae. Acetylcholinesterase reaction product was not seen intracellularly within any nerve processes. The reaction product was found around the somatic cell membranes and in the extracellular space between closely apposed nerve processes in the neuropile. Acetylcholinesterase reaction product was associated with synaptic endings that contained clear spheroidal synaptic vesicles, and the reaction product was localized at the site of synaptic contact between the zone of apposition of the pre- and postsynaptic terminals. This intracellular and extracellular distribution of the enzyme is consistent with its function as the degrading enzyme in cholinergic transmission.</description><subject>ACETILCOLINESTERASA</subject><subject>ACETYLCHOLINESTERASE</subject><subject>Acetylcholinesterase - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BRAIN</subject><subject>Cell Membrane - enzymology</subject><subject>Cell Nucleus - enzymology</subject><subject>CEREBRO</subject><subject>Cholinergic receptors</subject><subject>ENCEPHALE</subject><subject>Endoplasmic Reticulum - enzymology</subject><subject>FASCIOLA</subject><subject>Fasciola hepatica</subject><subject>Fasciola hepatica - enzymology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GANGLIA</subject><subject>GANGLION NERVEUX</subject><subject>GANGLIOS</subject><subject>Golgi Apparatus - enzymology</subject><subject>HISTOCHEMISTRY</subject><subject>Invertebrates</subject><subject>Microscopy, Electron</subject><subject>Nemathelminthia. Plathelmintha</subject><subject>Nerves</subject><subject>Nervous System - enzymology</subject><subject>Neurons</subject><subject>Neurons - enzymology</subject><subject>Neurons - ultrastructure</subject><subject>Neuropil</subject><subject>Neurotransmitters</subject><subject>Pain</subject><subject>Parasitology</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Reaction products</subject><subject>Synapses</subject><subject>Synapses - enzymology</subject><subject>Ultrastructure</subject><issn>0022-3395</issn><issn>1937-2345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrVDEQgIModa3iXSjkUPTiq0km2eQdS7FWKHiwPT9ms_N2U_Je1uQtsv56U_ZRb_WQhDDffMPMMPZeigsFwn4B5ZRS9gVbyBZso0Cbl2whhFINQGteszelPAghTD0n7AQqBUov2P4mlCn5LQ3BY-Qx1Tv8wSmkkaeeo6fpEP02xTBSmShjIR5GPm2Je8q0yjVpg-MmBnzkr7H4kCLyLe2qxONnjnyHNS3UH-8jTr9THt6yVz3GQu_m95TdX3-9u7ppbn98-351edt4cHpq0GppTOut9OjXmgQIDWvRCmeXirR1BkxtTpB1KFeS1FLiWsNSWLPslUE4ZR-P3l1Ov_a1gW4IxVOMOFLal64atK3W_4LSSAlCtBX8dAR9TqVk6rtdDgPmQydF97iJbt5EJc9m5X410PqJm0df4-dzvM4MY59x9KE8YRa0c9r8wx7qnvIz1T4csR5Th5tcTfc_nbPSCQV_AZ4ConE</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>Sukhdeo, S.C</creator><creator>Sukhdeo, M.V.K</creator><creator>Mettrick, D.F</creator><general>American Society of Parasitologists</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Histochemical localization of acetylcholinesterase in the cerebral ganglia of Fasciola hepatica, a parasitic flatworm</title><author>Sukhdeo, S.C ; Sukhdeo, M.V.K ; Mettrick, D.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-a741559c71cacd4e03043d0908762e4785353950e78a1b1e261ad4360756f25a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>ACETILCOLINESTERASA</topic><topic>ACETYLCHOLINESTERASE</topic><topic>Acetylcholinesterase - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BRAIN</topic><topic>Cell Membrane - enzymology</topic><topic>Cell Nucleus - enzymology</topic><topic>CEREBRO</topic><topic>Cholinergic receptors</topic><topic>ENCEPHALE</topic><topic>Endoplasmic Reticulum - enzymology</topic><topic>FASCIOLA</topic><topic>Fasciola hepatica</topic><topic>Fasciola hepatica - enzymology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GANGLIA</topic><topic>GANGLION NERVEUX</topic><topic>GANGLIOS</topic><topic>Golgi Apparatus - enzymology</topic><topic>HISTOCHEMISTRY</topic><topic>Invertebrates</topic><topic>Microscopy, Electron</topic><topic>Nemathelminthia. Plathelmintha</topic><topic>Nerves</topic><topic>Nervous System - enzymology</topic><topic>Neurons</topic><topic>Neurons - enzymology</topic><topic>Neurons - ultrastructure</topic><topic>Neuropil</topic><topic>Neurotransmitters</topic><topic>Pain</topic><topic>Parasitology</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Reaction products</topic><topic>Synapses</topic><topic>Synapses - enzymology</topic><topic>Ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukhdeo, S.C</creatorcontrib><creatorcontrib>Sukhdeo, M.V.K</creatorcontrib><creatorcontrib>Mettrick, D.F</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukhdeo, S.C</au><au>Sukhdeo, M.V.K</au><au>Mettrick, D.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histochemical localization of acetylcholinesterase in the cerebral ganglia of Fasciola hepatica, a parasitic flatworm</atitle><jtitle>The Journal of parasitology</jtitle><addtitle>J Parasitol</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>74</volume><issue>6</issue><spage>1023</spage><epage>1032</epage><pages>1023-1032</pages><issn>0022-3395</issn><eissn>1937-2345</eissn><coden>JOPAA2</coden><abstract>Acetylcholinesterase activity was found in the cell bodies and extracellularly in the neuropile of the cerebral ganglia of the adult trematode parasite, Fasciola hepatica. Within neuronal cell bodies of the cerebral ganglion, acetylcholinesterase reaction product was found in the endoplasmic reticulum, in the cisternae of the Golgi apparatus, and in secretory vesicles near the inner (releasing face) cisternae. Acetylcholinesterase reaction product was not seen intracellularly within any nerve processes. The reaction product was found around the somatic cell membranes and in the extracellular space between closely apposed nerve processes in the neuropile. Acetylcholinesterase reaction product was associated with synaptic endings that contained clear spheroidal synaptic vesicles, and the reaction product was localized at the site of synaptic contact between the zone of apposition of the pre- and postsynaptic terminals. This intracellular and extracellular distribution of the enzyme is consistent with its function as the degrading enzyme in cholinergic transmission.</abstract><cop>Lawrence, KS</cop><pub>American Society of Parasitologists</pub><pmid>3193324</pmid><doi>10.2307/3282227</doi><tpages>10</tpages></addata></record> |
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| subjects | ACETILCOLINESTERASA ACETYLCHOLINESTERASE Acetylcholinesterase - analysis Animals Biological and medical sciences BRAIN Cell Membrane - enzymology Cell Nucleus - enzymology CEREBRO Cholinergic receptors ENCEPHALE Endoplasmic Reticulum - enzymology FASCIOLA Fasciola hepatica Fasciola hepatica - enzymology Fundamental and applied biological sciences. Psychology GANGLIA GANGLION NERVEUX GANGLIOS Golgi Apparatus - enzymology HISTOCHEMISTRY Invertebrates Microscopy, Electron Nemathelminthia. Plathelmintha Nerves Nervous System - enzymology Neurons Neurons - enzymology Neurons - ultrastructure Neuropil Neurotransmitters Pain Parasitology RAT RATA RATS Reaction products Synapses Synapses - enzymology Ultrastructure |
| title | Histochemical localization of acetylcholinesterase in the cerebral ganglia of Fasciola hepatica, a parasitic flatworm |
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