Assessment of blood flow distal to coronary artery stenoses : Correlations between myocardial positron emission tomography and poststenotic intracoronary Doppler flow reserve
Previous studies have correlated quantitative coronary angiographic stenosis severity with positron emission tomography (PET) myocardial perfusion and proximal measurements of intracoronary flow velocities in normal and diseased coronary arteries. The aim of this study was to correlate regional myoc...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1996-11, Vol.94 (10), p.2447-2454 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | MILLER, D. D DONOHUE, T. J WOLFORD, T. L KERN, M. J BERGMANN, S. R CAULEY, M. B MECHEM, C. M HARTMAN, J. J |
| description | Previous studies have correlated quantitative coronary angiographic stenosis severity with positron emission tomography (PET) myocardial perfusion and proximal measurements of intracoronary flow velocities in normal and diseased coronary arteries. The aim of this study was to correlate regional myocardial blood flow (RMBF) derived from [15O]H2O PET with directly measured poststenotic intracoronary Doppler flow velocity data acquired under basal conditions and dipyridamole-induced hyperemia.
Eleven consecutive patients 53 +/- 13 years old with ischemic chest pain and isolated proximal left coronary artery stenoses (left anterior descending, 9; left circumflex, 2; mean, 59 +/- 23% diameter stenosis) underwent [15O]H2O myocardial PET and intracoronary Doppler flow velocity studies within 1 week. PET RMBF (mL.g-1.min-1) and myocardial perfusion reserve (MPR) were calculated in poststenotic and normal reference vascular beds. Poststenotic Doppler average peak flow velocities (APV; cm/s) and coronary flow velocity reserve (CFR) were compared with corresponding PET data and quantitative angiographic lesional parameters. PET RMBF and Doppler APV were linearly correlated (r = .60; P < .001), as were poststenotic PET MPR and Doppler CFR (r = .76; P < .0002). Relative coronary flow velocity and MPR ratios between poststenotic and angiographically normal vascular beds were comparably reduced (0.83 +/- 0.25 versus 0.86 +/- 0.21, respectively; P = NS).
Intracoronary Doppler flow velocities acquired distal to isolated left coronary artery stenoses correlated with [15O]H2O PET regional myocardial perfusion and are useful for assessment of the physiological significance of coronary stenoses in humans. |
| doi_str_mv | 10.1161/01.CIR.94.10.2447 |
| format | Article |
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Eleven consecutive patients 53 +/- 13 years old with ischemic chest pain and isolated proximal left coronary artery stenoses (left anterior descending, 9; left circumflex, 2; mean, 59 +/- 23% diameter stenosis) underwent [15O]H2O myocardial PET and intracoronary Doppler flow velocity studies within 1 week. PET RMBF (mL.g-1.min-1) and myocardial perfusion reserve (MPR) were calculated in poststenotic and normal reference vascular beds. Poststenotic Doppler average peak flow velocities (APV; cm/s) and coronary flow velocity reserve (CFR) were compared with corresponding PET data and quantitative angiographic lesional parameters. PET RMBF and Doppler APV were linearly correlated (r = .60; P < .001), as were poststenotic PET MPR and Doppler CFR (r = .76; P < .0002). Relative coronary flow velocity and MPR ratios between poststenotic and angiographically normal vascular beds were comparably reduced (0.83 +/- 0.25 versus 0.86 +/- 0.21, respectively; P = NS).
Intracoronary Doppler flow velocities acquired distal to isolated left coronary artery stenoses correlated with [15O]H2O PET regional myocardial perfusion and are useful for assessment of the physiological significance of coronary stenoses in humans.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.94.10.2447</identifier><identifier>PMID: 8921787</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Flow Velocity ; Cardiology. Vascular system ; Coronary Angiography ; Coronary Circulation ; Coronary Disease - diagnosis ; Coronary Disease - physiopathology ; Coronary heart disease ; Coronary Vessels - diagnostic imaging ; Dipyridamole ; Female ; Heart ; Hemodynamics ; Humans ; Male ; Medical sciences ; Middle Aged ; Tomography, Emission-Computed ; Ultrasonography, Interventional ; Vasodilator Agents</subject><ispartof>Circulation (New York, N.Y.), 1996-11, Vol.94 (10), p.2447-2454</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Nov 15, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c346t-449da8f3080b54d103b557967803b503439fbe01802dfdb03fa4610aae28d20a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2491345$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8921787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MILLER, D. D</creatorcontrib><creatorcontrib>DONOHUE, T. J</creatorcontrib><creatorcontrib>WOLFORD, T. L</creatorcontrib><creatorcontrib>KERN, M. J</creatorcontrib><creatorcontrib>BERGMANN, S. R</creatorcontrib><creatorcontrib>CAULEY, M. B</creatorcontrib><creatorcontrib>MECHEM, C. M</creatorcontrib><creatorcontrib>HARTMAN, J. J</creatorcontrib><title>Assessment of blood flow distal to coronary artery stenoses : Correlations between myocardial positron emission tomography and poststenotic intracoronary Doppler flow reserve</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Previous studies have correlated quantitative coronary angiographic stenosis severity with positron emission tomography (PET) myocardial perfusion and proximal measurements of intracoronary flow velocities in normal and diseased coronary arteries. The aim of this study was to correlate regional myocardial blood flow (RMBF) derived from [15O]H2O PET with directly measured poststenotic intracoronary Doppler flow velocity data acquired under basal conditions and dipyridamole-induced hyperemia.
Eleven consecutive patients 53 +/- 13 years old with ischemic chest pain and isolated proximal left coronary artery stenoses (left anterior descending, 9; left circumflex, 2; mean, 59 +/- 23% diameter stenosis) underwent [15O]H2O myocardial PET and intracoronary Doppler flow velocity studies within 1 week. PET RMBF (mL.g-1.min-1) and myocardial perfusion reserve (MPR) were calculated in poststenotic and normal reference vascular beds. Poststenotic Doppler average peak flow velocities (APV; cm/s) and coronary flow velocity reserve (CFR) were compared with corresponding PET data and quantitative angiographic lesional parameters. PET RMBF and Doppler APV were linearly correlated (r = .60; P < .001), as were poststenotic PET MPR and Doppler CFR (r = .76; P < .0002). Relative coronary flow velocity and MPR ratios between poststenotic and angiographically normal vascular beds were comparably reduced (0.83 +/- 0.25 versus 0.86 +/- 0.21, respectively; P = NS).
Intracoronary Doppler flow velocities acquired distal to isolated left coronary artery stenoses correlated with [15O]H2O PET regional myocardial perfusion and are useful for assessment of the physiological significance of coronary stenoses in humans.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography</subject><subject>Coronary Circulation</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Dipyridamole</subject><subject>Female</subject><subject>Heart</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Tomography, Emission-Computed</subject><subject>Ultrasonography, Interventional</subject><subject>Vasodilator Agents</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUstuFDEQtBBRWBI-gAOShRC3Wfyah7lFyyORIiEhch55xj0w0Yw9uL2J8lN8Iz3sag-c2u6uqi6rzNhrKbZSVvKDkNvdzfetNVvqKGPqZ2wjS2UKU2r7nG2EELaotVIv2EvEe7pWui7P2XljlaybesP-XCEC4gwh8zjwborR82GKj9yPmN3Ec-R9TDG49MRdykAFM4RILP6R72JKMLk8xoC8g_wIEPj8FHuX_EjsJeKYic1hHhEJRXpz_Jnc8ovkgl8B-Z9eHns-hpzcadunuCwTpIObBAjpAS7Z2eAmhFfHesHuvnz-sbsubr99vdld3Ra9NlUujLHeNYMWjehK46XQXVnWtqqb9SS00XboQMhGKD_4TujBmUoK50A1XgmnL9j7g-6S4u89YG7Jfw_T5ALEPbZ1U5rK1pKAb_8D3sd9CuStVVJVpqQlBJIHUJ8iYoKhXdI40xtbKdo1yFbIloJsrVk7a5DEeXMU3ncz-BPjmBzN3x3nDns3DcmFfsQTTBkrNf2Cvzshqno</recordid><startdate>19961115</startdate><enddate>19961115</enddate><creator>MILLER, D. D</creator><creator>DONOHUE, T. J</creator><creator>WOLFORD, T. L</creator><creator>KERN, M. J</creator><creator>BERGMANN, S. R</creator><creator>CAULEY, M. B</creator><creator>MECHEM, C. M</creator><creator>HARTMAN, J. J</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19961115</creationdate><title>Assessment of blood flow distal to coronary artery stenoses : Correlations between myocardial positron emission tomography and poststenotic intracoronary Doppler flow reserve</title><author>MILLER, D. D ; DONOHUE, T. J ; WOLFORD, T. L ; KERN, M. J ; BERGMANN, S. R ; CAULEY, M. B ; MECHEM, C. M ; HARTMAN, J. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-449da8f3080b54d103b557967803b503439fbe01802dfdb03fa4610aae28d20a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography</topic><topic>Coronary Circulation</topic><topic>Coronary Disease - diagnosis</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Dipyridamole</topic><topic>Female</topic><topic>Heart</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Tomography, Emission-Computed</topic><topic>Ultrasonography, Interventional</topic><topic>Vasodilator Agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MILLER, D. D</creatorcontrib><creatorcontrib>DONOHUE, T. J</creatorcontrib><creatorcontrib>WOLFORD, T. L</creatorcontrib><creatorcontrib>KERN, M. J</creatorcontrib><creatorcontrib>BERGMANN, S. R</creatorcontrib><creatorcontrib>CAULEY, M. B</creatorcontrib><creatorcontrib>MECHEM, C. M</creatorcontrib><creatorcontrib>HARTMAN, J. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MILLER, D. D</au><au>DONOHUE, T. J</au><au>WOLFORD, T. L</au><au>KERN, M. J</au><au>BERGMANN, S. R</au><au>CAULEY, M. B</au><au>MECHEM, C. M</au><au>HARTMAN, J. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of blood flow distal to coronary artery stenoses : Correlations between myocardial positron emission tomography and poststenotic intracoronary Doppler flow reserve</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1996-11-15</date><risdate>1996</risdate><volume>94</volume><issue>10</issue><spage>2447</spage><epage>2454</epage><pages>2447-2454</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Previous studies have correlated quantitative coronary angiographic stenosis severity with positron emission tomography (PET) myocardial perfusion and proximal measurements of intracoronary flow velocities in normal and diseased coronary arteries. The aim of this study was to correlate regional myocardial blood flow (RMBF) derived from [15O]H2O PET with directly measured poststenotic intracoronary Doppler flow velocity data acquired under basal conditions and dipyridamole-induced hyperemia.
Eleven consecutive patients 53 +/- 13 years old with ischemic chest pain and isolated proximal left coronary artery stenoses (left anterior descending, 9; left circumflex, 2; mean, 59 +/- 23% diameter stenosis) underwent [15O]H2O myocardial PET and intracoronary Doppler flow velocity studies within 1 week. PET RMBF (mL.g-1.min-1) and myocardial perfusion reserve (MPR) were calculated in poststenotic and normal reference vascular beds. Poststenotic Doppler average peak flow velocities (APV; cm/s) and coronary flow velocity reserve (CFR) were compared with corresponding PET data and quantitative angiographic lesional parameters. PET RMBF and Doppler APV were linearly correlated (r = .60; P < .001), as were poststenotic PET MPR and Doppler CFR (r = .76; P < .0002). Relative coronary flow velocity and MPR ratios between poststenotic and angiographically normal vascular beds were comparably reduced (0.83 +/- 0.25 versus 0.86 +/- 0.21, respectively; P = NS).
Intracoronary Doppler flow velocities acquired distal to isolated left coronary artery stenoses correlated with [15O]H2O PET regional myocardial perfusion and are useful for assessment of the physiological significance of coronary stenoses in humans.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>8921787</pmid><doi>10.1161/01.CIR.94.10.2447</doi><tpages>8</tpages></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 1996-11, Vol.94 (10), p.2447-2454 |
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| subjects | Adult Aged Biological and medical sciences Blood Flow Velocity Cardiology. Vascular system Coronary Angiography Coronary Circulation Coronary Disease - diagnosis Coronary Disease - physiopathology Coronary heart disease Coronary Vessels - diagnostic imaging Dipyridamole Female Heart Hemodynamics Humans Male Medical sciences Middle Aged Tomography, Emission-Computed Ultrasonography, Interventional Vasodilator Agents |
| title | Assessment of blood flow distal to coronary artery stenoses : Correlations between myocardial positron emission tomography and poststenotic intracoronary Doppler flow reserve |
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