Diethylcarbamazine-Induced Reversal of Early Lymphatic Dysfunction in a Patient with Bancroftian Filariasis: Assessment with Use of Lymphoscintigraphy
Exposure of expatriates to the infective larvae of Wuchereria bancrofti can result in the early development of signs of lymphatic obstruction. The findings on the clinical presentation of expatriates are distinct from the chronic pathological findings seen among the native population and are similar...
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| Veröffentlicht in: | Clinical infectious diseases 1996-11, Vol.23 (5), p.1007-1011 |
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| container_title | Clinical infectious diseases |
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| creator | Moore, Thomas A. Reynolds, James C. Kenney, Richard T. Johnston, William Nutman, Thomas B. |
| description | Exposure of expatriates to the infective larvae of Wuchereria bancrofti can result in the early development of signs of lymphatic obstruction. The findings on the clinical presentation of expatriates are distinct from the chronic pathological findings seen among the native population and are similar to the findings in experimentally infected persons. We report the case of a Peace Corps volunteer who developed acute lymphatic dysfunction within 3 months of arriving in an area that was endemic for filariasis. The diagnosis was established clinically and by demonstrating the presence of antibodies to recombinant proteins specific for patients with lymphatic filariasis. Lymphatic flow was markedly abnormal when assessed with use of 99mTc-lymphoscintigraphy. Treatment with diethylcarbamazine reversed both the physical and lymphoscintigraphic abnormalities. |
| doi_str_mv | 10.1093/clinids/23.5.1007 |
| format | Article |
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The findings on the clinical presentation of expatriates are distinct from the chronic pathological findings seen among the native population and are similar to the findings in experimentally infected persons. We report the case of a Peace Corps volunteer who developed acute lymphatic dysfunction within 3 months of arriving in an area that was endemic for filariasis. The diagnosis was established clinically and by demonstrating the presence of antibodies to recombinant proteins specific for patients with lymphatic filariasis. Lymphatic flow was markedly abnormal when assessed with use of 99mTc-lymphoscintigraphy. Treatment with diethylcarbamazine reversed both the physical and lymphoscintigraphic abnormalities.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/clinids/23.5.1007</identifier><identifier>PMID: 8922794</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Adults ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antibodies ; Antibodies, Helminth - analysis ; Antiparasitic agents ; Biological and medical sciences ; Clinical Articles ; Diethylcarbamazine - therapeutic use ; Elephantiasis, Filarial - diagnostic imaging ; Elephantiasis, Filarial - drug therapy ; Elephantiasis, Filarial - immunology ; Elephantiasis, Filarial - physiopathology ; Eosinophilia ; Eosinophils ; Filarial elephantiasis ; Filariasis ; Humans ; Infections ; Intestinal volvulus ; Larval development ; Lymphoscintigraphy ; Magnetic Resonance Imaging ; Medical sciences ; Pharmacology. Drug treatments ; Radionuclide Imaging ; Wuchereria bancrofti - immunology ; Wuchereria bancrofti - isolation & purification</subject><ispartof>Clinical infectious diseases, 1996-11, Vol.23 (5), p.1007-1011</ispartof><rights>Copyright 1996 The University of Chicago</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-fb0409f9b9c18cde8a0ec227954788c0a1c1f4a0be24b5410ba8cfaa7884133a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4459777$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4459777$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2477543$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8922794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, Thomas A.</creatorcontrib><creatorcontrib>Reynolds, James C.</creatorcontrib><creatorcontrib>Kenney, Richard T.</creatorcontrib><creatorcontrib>Johnston, William</creatorcontrib><creatorcontrib>Nutman, Thomas B.</creatorcontrib><title>Diethylcarbamazine-Induced Reversal of Early Lymphatic Dysfunction in a Patient with Bancroftian Filariasis: Assessment with Use of Lymphoscintigraphy</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Exposure of expatriates to the infective larvae of Wuchereria bancrofti can result in the early development of signs of lymphatic obstruction. The findings on the clinical presentation of expatriates are distinct from the chronic pathological findings seen among the native population and are similar to the findings in experimentally infected persons. We report the case of a Peace Corps volunteer who developed acute lymphatic dysfunction within 3 months of arriving in an area that was endemic for filariasis. The diagnosis was established clinically and by demonstrating the presence of antibodies to recombinant proteins specific for patients with lymphatic filariasis. Lymphatic flow was markedly abnormal when assessed with use of 99mTc-lymphoscintigraphy. Treatment with diethylcarbamazine reversed both the physical and lymphoscintigraphic abnormalities.</description><subject>Adult</subject><subject>Adults</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antibodies</subject><subject>Antibodies, Helminth - analysis</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Clinical Articles</subject><subject>Diethylcarbamazine - therapeutic use</subject><subject>Elephantiasis, Filarial - diagnostic imaging</subject><subject>Elephantiasis, Filarial - drug therapy</subject><subject>Elephantiasis, Filarial - immunology</subject><subject>Elephantiasis, Filarial - physiopathology</subject><subject>Eosinophilia</subject><subject>Eosinophils</subject><subject>Filarial elephantiasis</subject><subject>Filariasis</subject><subject>Humans</subject><subject>Infections</subject><subject>Intestinal volvulus</subject><subject>Larval development</subject><subject>Lymphoscintigraphy</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Radionuclide Imaging</subject><subject>Wuchereria bancrofti - immunology</subject><subject>Wuchereria bancrofti - isolation & purification</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kd1u1DAQhSMEKqXwAEgg-QJxl9aO7bXDXX9ppVWpWCpV3FgTr8O6JM7icYDwIDwvCbvKla35zpzRzMmy14weM1ryE9v44Nd4UvBjOVaoepIdMslVvpAlezr-qdS50Fw_z14gPlLKmKbyIDvQZVGoUhxmfy-8S5uhsRAraOGPDy6_CeveujX57H66iNCQriaXEJuBLId2u4HkLbkYsO6DTb4LxAcC5G4su5DIL5825AyCjV2dPARy5RuIHtDjB3KK6BDbWXePbjL_b9uh9SH5bxG2m-Fl9qyGBt2r_XuU3V9dfjm_zpefPt6cny5zKwqV8rqigpZ1WZWWabt2Gqiz02ZSKK0tBWZZLYBWrhCVFIxWoG0NMELBOAd-lL3f-W5j96N3mEzr0bqmgeC6Ho3SUkgpi1HIdsJxL8ToarONvoU4GEbNlIXZZ2EKbqSZshh73u7N-6p167ljf_yRv9tzQAtNHcereZxlhVBKCj7K3uxkj5i6OGMhZKnUNCXfYY_J_Z4xxO9mobiS5vrhq1ndLW5Xt8XKPPB_vvGwSg</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Moore, Thomas A.</creator><creator>Reynolds, James C.</creator><creator>Kenney, Richard T.</creator><creator>Johnston, William</creator><creator>Nutman, Thomas B.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Diethylcarbamazine-Induced Reversal of Early Lymphatic Dysfunction in a Patient with Bancroftian Filariasis: Assessment with Use of Lymphoscintigraphy</title><author>Moore, Thomas A. ; Reynolds, James C. ; Kenney, Richard T. ; Johnston, William ; Nutman, Thomas B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-fb0409f9b9c18cde8a0ec227954788c0a1c1f4a0be24b5410ba8cfaa7884133a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antibodies</topic><topic>Antibodies, Helminth - analysis</topic><topic>Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Clinical Articles</topic><topic>Diethylcarbamazine - therapeutic use</topic><topic>Elephantiasis, Filarial - diagnostic imaging</topic><topic>Elephantiasis, Filarial - drug therapy</topic><topic>Elephantiasis, Filarial - immunology</topic><topic>Elephantiasis, Filarial - physiopathology</topic><topic>Eosinophilia</topic><topic>Eosinophils</topic><topic>Filarial elephantiasis</topic><topic>Filariasis</topic><topic>Humans</topic><topic>Infections</topic><topic>Intestinal volvulus</topic><topic>Larval development</topic><topic>Lymphoscintigraphy</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Radionuclide Imaging</topic><topic>Wuchereria bancrofti - immunology</topic><topic>Wuchereria bancrofti - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moore, Thomas A.</creatorcontrib><creatorcontrib>Reynolds, James C.</creatorcontrib><creatorcontrib>Kenney, Richard T.</creatorcontrib><creatorcontrib>Johnston, William</creatorcontrib><creatorcontrib>Nutman, Thomas B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, Thomas A.</au><au>Reynolds, James C.</au><au>Kenney, Richard T.</au><au>Johnston, William</au><au>Nutman, Thomas B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diethylcarbamazine-Induced Reversal of Early Lymphatic Dysfunction in a Patient with Bancroftian Filariasis: Assessment with Use of Lymphoscintigraphy</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>23</volume><issue>5</issue><spage>1007</spage><epage>1011</epage><pages>1007-1011</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Exposure of expatriates to the infective larvae of Wuchereria bancrofti can result in the early development of signs of lymphatic obstruction. The findings on the clinical presentation of expatriates are distinct from the chronic pathological findings seen among the native population and are similar to the findings in experimentally infected persons. We report the case of a Peace Corps volunteer who developed acute lymphatic dysfunction within 3 months of arriving in an area that was endemic for filariasis. The diagnosis was established clinically and by demonstrating the presence of antibodies to recombinant proteins specific for patients with lymphatic filariasis. Lymphatic flow was markedly abnormal when assessed with use of 99mTc-lymphoscintigraphy. Treatment with diethylcarbamazine reversed both the physical and lymphoscintigraphic abnormalities.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8922794</pmid><doi>10.1093/clinids/23.5.1007</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical infectious diseases, 1996-11, Vol.23 (5), p.1007-1011 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Adults Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies Antibodies, Helminth - analysis Antiparasitic agents Biological and medical sciences Clinical Articles Diethylcarbamazine - therapeutic use Elephantiasis, Filarial - diagnostic imaging Elephantiasis, Filarial - drug therapy Elephantiasis, Filarial - immunology Elephantiasis, Filarial - physiopathology Eosinophilia Eosinophils Filarial elephantiasis Filariasis Humans Infections Intestinal volvulus Larval development Lymphoscintigraphy Magnetic Resonance Imaging Medical sciences Pharmacology. Drug treatments Radionuclide Imaging Wuchereria bancrofti - immunology Wuchereria bancrofti - isolation & purification |
| title | Diethylcarbamazine-Induced Reversal of Early Lymphatic Dysfunction in a Patient with Bancroftian Filariasis: Assessment with Use of Lymphoscintigraphy |
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