Gliosarcoma developing from an irradiated ependymoma
A 17-year-old girl was operated for a cystic mass located deep within the left parieto-occipital white matter. Histologically the tumor was an ependymoma with a vascular stroma. In spite of irradiation the tumor recurred locally twice, 1 and 2 years respectively after the original operation. The epe...
Gespeichert in:
Veröffentlicht in: | Acta neuropathologica 1996-11, Vol.92 (5), p.515-519 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 519 |
---|---|
container_issue | 5 |
container_start_page | 515 |
container_title | Acta neuropathologica |
container_volume | 92 |
creator | KEPES, J. J BASTIAN, F. O WEBER, E. D |
description | A 17-year-old girl was operated for a cystic mass located deep within the left parieto-occipital white matter. Histologically the tumor was an ependymoma with a vascular stroma. In spite of irradiation the tumor recurred locally twice, 1 and 2 years respectively after the original operation. The ependymoma portion of the tumor remained unchanged, but the stroma showed increased vascular hyperplasia at the time of the second operation and transformation into a fibrosarcoma in the third operative specimen. Proliferating cell markers (MIB-1) were positive only in the ependymoma cell nuclei in the first two specimens, but were also extensively present in the nuclei of the fibrosarcoma in the third specimen. In the latter, the fibrosarcoma portion greatly overwhelmed the residual ependymoma islands, but remained sharply delineated from them. This is the first observed case of a gliosarcoma originating from an ependymoma. The histological pattern of this mixed tumor clearly indicates that the source of the sarcomatous portions was the neoplastically transformed fibrovascular stroma of the original tumor, rather than "desmoplastic" alterations of the neoplastic ependymal cells themselves. |
doi_str_mv | 10.1007/s004010050554 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78545546</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78545546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c317t-1f77d97d5b39a810004c58b892c0abddc1ab829a609cd83c208bbd01264f1e923</originalsourceid><addsrcrecordid>eNpVkMtLw0AQxhdRaqwePQo5iLfo7CvZPUrRKhS86DnMPiKRvNxthf73rjQUPM0M34-Zbz5CrincU4DqIQIISJ0EKcUJyajgrADJ-SnJAIAWJWfsnFzE-JUmVgm5IAulGYNSZESsu3aMGOzYY-78j-_GqR0-8yaMfY5D3oaArsWtd7mf_OD2fQIvyVmDXfRXc12Sj-en99VLsXlbv64eN4XltNoWtKkqpysnDdeokkUQViqTbltA45ylaBTTWIK2TnHLQBnjksdSNNRrxpfk7rB3CuP3zsdt3bfR-q7DwY-7WFdKivR0mcDiANowxhh8U0-h7THsawr1X0r1v5QSfzMv3pneuyM9x5L021nHaLFrAg62jUeMM8lLofkvYQ5tgg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78545546</pqid></control><display><type>article</type><title>Gliosarcoma developing from an irradiated ependymoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>KEPES, J. J ; BASTIAN, F. O ; WEBER, E. D</creator><creatorcontrib>KEPES, J. J ; BASTIAN, F. O ; WEBER, E. D</creatorcontrib><description>A 17-year-old girl was operated for a cystic mass located deep within the left parieto-occipital white matter. Histologically the tumor was an ependymoma with a vascular stroma. In spite of irradiation the tumor recurred locally twice, 1 and 2 years respectively after the original operation. The ependymoma portion of the tumor remained unchanged, but the stroma showed increased vascular hyperplasia at the time of the second operation and transformation into a fibrosarcoma in the third operative specimen. Proliferating cell markers (MIB-1) were positive only in the ependymoma cell nuclei in the first two specimens, but were also extensively present in the nuclei of the fibrosarcoma in the third specimen. In the latter, the fibrosarcoma portion greatly overwhelmed the residual ependymoma islands, but remained sharply delineated from them. This is the first observed case of a gliosarcoma originating from an ependymoma. The histological pattern of this mixed tumor clearly indicates that the source of the sarcomatous portions was the neoplastically transformed fibrovascular stroma of the original tumor, rather than "desmoplastic" alterations of the neoplastic ependymal cells themselves.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010050554</identifier><identifier>PMID: 8922064</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Brain Neoplasms - pathology ; Diseases of the nervous system ; Ependymoma - pathology ; Female ; Gliosarcoma - complications ; Gliosarcoma - pathology ; Humans ; Medical sciences ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><ispartof>Acta neuropathologica, 1996-11, Vol.92 (5), p.515-519</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-1f77d97d5b39a810004c58b892c0abddc1ab829a609cd83c208bbd01264f1e923</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3253649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8922064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KEPES, J. J</creatorcontrib><creatorcontrib>BASTIAN, F. O</creatorcontrib><creatorcontrib>WEBER, E. D</creatorcontrib><title>Gliosarcoma developing from an irradiated ependymoma</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>A 17-year-old girl was operated for a cystic mass located deep within the left parieto-occipital white matter. Histologically the tumor was an ependymoma with a vascular stroma. In spite of irradiation the tumor recurred locally twice, 1 and 2 years respectively after the original operation. The ependymoma portion of the tumor remained unchanged, but the stroma showed increased vascular hyperplasia at the time of the second operation and transformation into a fibrosarcoma in the third operative specimen. Proliferating cell markers (MIB-1) were positive only in the ependymoma cell nuclei in the first two specimens, but were also extensively present in the nuclei of the fibrosarcoma in the third specimen. In the latter, the fibrosarcoma portion greatly overwhelmed the residual ependymoma islands, but remained sharply delineated from them. This is the first observed case of a gliosarcoma originating from an ependymoma. The histological pattern of this mixed tumor clearly indicates that the source of the sarcomatous portions was the neoplastically transformed fibrovascular stroma of the original tumor, rather than "desmoplastic" alterations of the neoplastic ependymal cells themselves.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - pathology</subject><subject>Diseases of the nervous system</subject><subject>Ependymoma - pathology</subject><subject>Female</subject><subject>Gliosarcoma - complications</subject><subject>Gliosarcoma - pathology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtLw0AQxhdRaqwePQo5iLfo7CvZPUrRKhS86DnMPiKRvNxthf73rjQUPM0M34-Zbz5CrincU4DqIQIISJ0EKcUJyajgrADJ-SnJAIAWJWfsnFzE-JUmVgm5IAulGYNSZESsu3aMGOzYY-78j-_GqR0-8yaMfY5D3oaArsWtd7mf_OD2fQIvyVmDXfRXc12Sj-en99VLsXlbv64eN4XltNoWtKkqpysnDdeokkUQViqTbltA45ylaBTTWIK2TnHLQBnjksdSNNRrxpfk7rB3CuP3zsdt3bfR-q7DwY-7WFdKivR0mcDiANowxhh8U0-h7THsawr1X0r1v5QSfzMv3pneuyM9x5L021nHaLFrAg62jUeMM8lLofkvYQ5tgg</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>KEPES, J. J</creator><creator>BASTIAN, F. O</creator><creator>WEBER, E. D</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Gliosarcoma developing from an irradiated ependymoma</title><author>KEPES, J. J ; BASTIAN, F. O ; WEBER, E. D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-1f77d97d5b39a810004c58b892c0abddc1ab829a609cd83c208bbd01264f1e923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - pathology</topic><topic>Diseases of the nervous system</topic><topic>Ependymoma - pathology</topic><topic>Female</topic><topic>Gliosarcoma - complications</topic><topic>Gliosarcoma - pathology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KEPES, J. J</creatorcontrib><creatorcontrib>BASTIAN, F. O</creatorcontrib><creatorcontrib>WEBER, E. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KEPES, J. J</au><au>BASTIAN, F. O</au><au>WEBER, E. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gliosarcoma developing from an irradiated ependymoma</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>92</volume><issue>5</issue><spage>515</spage><epage>519</epage><pages>515-519</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>A 17-year-old girl was operated for a cystic mass located deep within the left parieto-occipital white matter. Histologically the tumor was an ependymoma with a vascular stroma. In spite of irradiation the tumor recurred locally twice, 1 and 2 years respectively after the original operation. The ependymoma portion of the tumor remained unchanged, but the stroma showed increased vascular hyperplasia at the time of the second operation and transformation into a fibrosarcoma in the third operative specimen. Proliferating cell markers (MIB-1) were positive only in the ependymoma cell nuclei in the first two specimens, but were also extensively present in the nuclei of the fibrosarcoma in the third specimen. In the latter, the fibrosarcoma portion greatly overwhelmed the residual ependymoma islands, but remained sharply delineated from them. This is the first observed case of a gliosarcoma originating from an ependymoma. The histological pattern of this mixed tumor clearly indicates that the source of the sarcomatous portions was the neoplastically transformed fibrovascular stroma of the original tumor, rather than "desmoplastic" alterations of the neoplastic ependymal cells themselves.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8922064</pmid><doi>10.1007/s004010050554</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0001-6322 |
ispartof | Acta neuropathologica, 1996-11, Vol.92 (5), p.515-519 |
issn | 0001-6322 1432-0533 |
language | eng |
recordid | cdi_proquest_miscellaneous_78545546 |
source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Adolescent Biological and medical sciences Brain Neoplasms - pathology Diseases of the nervous system Ependymoma - pathology Female Gliosarcoma - complications Gliosarcoma - pathology Humans Medical sciences Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) |
title | Gliosarcoma developing from an irradiated ependymoma |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T23%3A54%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gliosarcoma%20developing%20from%20an%20irradiated%20ependymoma&rft.jtitle=Acta%20neuropathologica&rft.au=KEPES,%20J.%20J&rft.date=1996-11-01&rft.volume=92&rft.issue=5&rft.spage=515&rft.epage=519&rft.pages=515-519&rft.issn=0001-6322&rft.eissn=1432-0533&rft.coden=ANPTAL&rft_id=info:doi/10.1007/s004010050554&rft_dat=%3Cproquest_cross%3E78545546%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78545546&rft_id=info:pmid/8922064&rfr_iscdi=true |