Radioisotopic Measurement of Glomerular Filtration Rate in Severe Chronic Renal Failure
In order to determine the best method for routine measurement of glomerular filtration rate (GFR) in severe renal failure, we compared simultaneously the urinary clearances of [99mTc] diethylenetriaminepentaacetic acid (DTPA) (UD), [125I]iothalamate (UI), 24-hr creatinine clearance (UC) and plasma c...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1988-12, Vol.29 (12), p.1927-1930 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | LaFrance, Norman D Drew, Helen H Walser, Mackenzie |
| description | In order to determine the best method for routine measurement of glomerular filtration rate (GFR) in severe renal failure, we compared simultaneously the urinary clearances of [99mTc] diethylenetriaminepentaacetic acid (DTPA) (UD), [125I]iothalamate (UI), 24-hr creatinine clearance (UC) and plasma clearance of [99mTc]DTPA (PD), based on three plasma samples. In 60 studies in 22 patients with serum creatinine values of 2 to 8 mg/dl, UD and UI were almost identical: UD = 0.358 +/- 0.976 UI +/- 0.87 ml/min, r = 0.990. However, PD overestimated UD by a large and variable extent: PD = 11.3 +/- 0.843 UD +/- 5.5 ml/min, r = 0.694, and was inconsistent in sequential measurements in individual patients. UC also overestimated urinary isotope clearance: UC = 4.2 + 0.95 UI +/- 3.9 ml/min, r = 0.865. Sequential measurements of GFR in five patients with severe but stable renal failure (mean GFR 5.9 ml/min) showed an average standard deviation of only 0.83 ml/min. Thus both UD and UI appear to be reliable and precise measures of GFR in severe renal failure. |
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In 60 studies in 22 patients with serum creatinine values of 2 to 8 mg/dl, UD and UI were almost identical: UD = 0.358 +/- 0.976 UI +/- 0.87 ml/min, r = 0.990. However, PD overestimated UD by a large and variable extent: PD = 11.3 +/- 0.843 UD +/- 5.5 ml/min, r = 0.694, and was inconsistent in sequential measurements in individual patients. UC also overestimated urinary isotope clearance: UC = 4.2 + 0.95 UI +/- 3.9 ml/min, r = 0.865. Sequential measurements of GFR in five patients with severe but stable renal failure (mean GFR 5.9 ml/min) showed an average standard deviation of only 0.83 ml/min. 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In 60 studies in 22 patients with serum creatinine values of 2 to 8 mg/dl, UD and UI were almost identical: UD = 0.358 +/- 0.976 UI +/- 0.87 ml/min, r = 0.990. However, PD overestimated UD by a large and variable extent: PD = 11.3 +/- 0.843 UD +/- 5.5 ml/min, r = 0.694, and was inconsistent in sequential measurements in individual patients. UC also overestimated urinary isotope clearance: UC = 4.2 + 0.95 UI +/- 3.9 ml/min, r = 0.865. Sequential measurements of GFR in five patients with severe but stable renal failure (mean GFR 5.9 ml/min) showed an average standard deviation of only 0.83 ml/min. Thus both UD and UI appear to be reliable and precise measures of GFR in severe renal failure.</description><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Iothalamic Acid</subject><subject>Kidney Failure, Chronic - diagnostic imaging</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Male</subject><subject>Organometallic Compounds</subject><subject>Pentetic Acid</subject><subject>Radioisotope Renography</subject><subject>Technetium Tc 99m Pentetate</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkE9LwzAchoMoc04_gpCTeCk0SfOnRxlOhYkwFY8lTX51GWkyk1bx21vZTu_hed738J6gOeGMF1wIeYrmJRGk4Lzk5-gi511ZlkIpNUMzVnJJaD1HHxttXXQ5DnHvDH4GnccEPYQBxw4_-NhDGr1OeOX8kPTgYsAbPQB2Ab_CNyTAy22KYepuIGiPV9r5aeESnXXaZ7g65gK9r-7flo_F-uXhaXm3LraU1UOhtGiJER0XlkkgdctsBcBNJzppK9syZVpKrFS0s9xw2VpFQdZQcWCGKssW6Oawu0_xa4Q8NL3LBrzXAeKYG6l4VZUVncTrozi2Pdhmn1yv029zfGLitwe-dZ_bH5egCaPxoNO_vAs9rRtCG1JTyf4Aih9qVw</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>LaFrance, Norman D</creator><creator>Drew, Helen H</creator><creator>Walser, Mackenzie</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Radioisotopic Measurement of Glomerular Filtration Rate in Severe Chronic Renal Failure</title><author>LaFrance, Norman D ; Drew, Helen H ; Walser, Mackenzie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h239t-8a6b1c6f56d37e19b3d4ee5cf6f7d4db38cb21d782fd5c57bd82e79e45e3c28d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Iothalamic Acid</topic><topic>Kidney Failure, Chronic - diagnostic imaging</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Male</topic><topic>Organometallic Compounds</topic><topic>Pentetic Acid</topic><topic>Radioisotope Renography</topic><topic>Technetium Tc 99m Pentetate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LaFrance, Norman D</creatorcontrib><creatorcontrib>Drew, Helen H</creatorcontrib><creatorcontrib>Walser, Mackenzie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LaFrance, Norman D</au><au>Drew, Helen H</au><au>Walser, Mackenzie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioisotopic Measurement of Glomerular Filtration Rate in Severe Chronic Renal Failure</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>29</volume><issue>12</issue><spage>1927</spage><epage>1930</epage><pages>1927-1930</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>In order to determine the best method for routine measurement of glomerular filtration rate (GFR) in severe renal failure, we compared simultaneously the urinary clearances of [99mTc] diethylenetriaminepentaacetic acid (DTPA) (UD), [125I]iothalamate (UI), 24-hr creatinine clearance (UC) and plasma clearance of [99mTc]DTPA (PD), based on three plasma samples. In 60 studies in 22 patients with serum creatinine values of 2 to 8 mg/dl, UD and UI were almost identical: UD = 0.358 +/- 0.976 UI +/- 0.87 ml/min, r = 0.990. However, PD overestimated UD by a large and variable extent: PD = 11.3 +/- 0.843 UD +/- 5.5 ml/min, r = 0.694, and was inconsistent in sequential measurements in individual patients. UC also overestimated urinary isotope clearance: UC = 4.2 + 0.95 UI +/- 3.9 ml/min, r = 0.865. Sequential measurements of GFR in five patients with severe but stable renal failure (mean GFR 5.9 ml/min) showed an average standard deviation of only 0.83 ml/min. Thus both UD and UI appear to be reliable and precise measures of GFR in severe renal failure.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>3057129</pmid><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1988-12, Vol.29 (12), p.1927-1930 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Female Glomerular Filtration Rate Humans Iodine Radioisotopes Iothalamic Acid Kidney Failure, Chronic - diagnostic imaging Kidney Failure, Chronic - physiopathology Male Organometallic Compounds Pentetic Acid Radioisotope Renography Technetium Tc 99m Pentetate |
| title | Radioisotopic Measurement of Glomerular Filtration Rate in Severe Chronic Renal Failure |
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