Glomerular disease during HCV infection in renal transplantation
In general nephrology, HCV infection has been associated with type I membranoproliferative glomerulonephritis (MPGN type I) associated with cryoglobulinaemia. In a cohort of 399 renal transplantation (RT) recipients, 117 of whom (29%) were HCV-positive, we selected all patients diagnosed as having m...
Gespeichert in:
| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 1996, Vol.11 (supp4), p.54-55 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 55 |
|---|---|
| container_issue | supp4 |
| container_start_page | 54 |
| container_title | Nephrology, dialysis, transplantation |
| container_volume | 11 |
| creator | HAMMOUD, H HAEM, J LAURENT, B ALAMARTINE, E DIAB, N DEFILIPPIS, J. P BERTHOUX, P BERTHOUX, F |
| description | In general nephrology, HCV infection has been associated with type I membranoproliferative glomerulonephritis (MPGN type I) associated with cryoglobulinaemia. In a cohort of 399 renal transplantation (RT) recipients, 117 of whom (29%) were HCV-positive, we selected all patients diagnosed as having membranous GN or type I MPGN by graft biopsy. The prevalence of MGN was 16/399 (4%) with three recurrences, and 13 de novo cases. Only 5/16 (31%) were HCV+, not different from the general RT population. Five patients had an outcome of graft failure after 43 months. Conversely, there were 15 cases of type I MPGN (two recurrences, 13 de novo) but with eight HCV+ recipients (53%, P = 0.02). Considering only the French patients, prevalence was 44% vs 12% in the French RT population (P = 0.006). Eight patients had graft rejection after 59 months (five HCV+). In this type I MPGN subgroup, there were two positive cryoglobulins, two rheumatoid factors and four hypocomplementaemias. In conclusion, there is a clear association between HCV infection and the occurrence of type I MPGN in the allograft in renal transplantation, with terminal renal failure as an outcome. |
| doi_str_mv | 10.1093/ndt/11.supp4.54 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78542856</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78542856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-88c1e6c516b8ddd5beb4fc55cd69444e98b01131710175649a88b5eca349f28e3</originalsourceid><addsrcrecordid>eNo9kD1PwzAQhi0EKqUwMyFlQGxpfbGd2BuoghapEguwWo59QUH5wk4G_j0urTrdSe9zr04PIbdAl0AVW3VuXAEswzQMfCn4GZkDz2maMSnOyTwSkFJB1SW5CuGbUqqyopiRmVQgC5HPyeOm6Vv0U2N84uqAJmDiJl93X8l2_ZnUXYV2rPsubonHzjTJ6E0XhsZ0o9kH1-SiMk3Am-NckI-X5_f1Nt29bV7XT7vUsjwbUyktYG4F5KV0zokSS15ZIazLFecclSwpAIMCKMTHuDJSlgKtYVxVmUS2IA-H3sH3PxOGUbd1sNjER7Cfgi6k4JkUeQRXB9D6PgSPlR583Rr_q4HqvTMdnWkA_e9MCx4v7o7VU9miO_FHSTG_P-YmWNNUUYCtwwljGaegGPsD5D92KA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78542856</pqid></control><display><type>article</type><title>Glomerular disease during HCV infection in renal transplantation</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>HAMMOUD, H ; HAEM, J ; LAURENT, B ; ALAMARTINE, E ; DIAB, N ; DEFILIPPIS, J. P ; BERTHOUX, P ; BERTHOUX, F</creator><creatorcontrib>HAMMOUD, H ; HAEM, J ; LAURENT, B ; ALAMARTINE, E ; DIAB, N ; DEFILIPPIS, J. P ; BERTHOUX, P ; BERTHOUX, F</creatorcontrib><description>In general nephrology, HCV infection has been associated with type I membranoproliferative glomerulonephritis (MPGN type I) associated with cryoglobulinaemia. In a cohort of 399 renal transplantation (RT) recipients, 117 of whom (29%) were HCV-positive, we selected all patients diagnosed as having membranous GN or type I MPGN by graft biopsy. The prevalence of MGN was 16/399 (4%) with three recurrences, and 13 de novo cases. Only 5/16 (31%) were HCV+, not different from the general RT population. Five patients had an outcome of graft failure after 43 months. Conversely, there were 15 cases of type I MPGN (two recurrences, 13 de novo) but with eight HCV+ recipients (53%, P = 0.02). Considering only the French patients, prevalence was 44% vs 12% in the French RT population (P = 0.006). Eight patients had graft rejection after 59 months (five HCV+). In this type I MPGN subgroup, there were two positive cryoglobulins, two rheumatoid factors and four hypocomplementaemias. In conclusion, there is a clear association between HCV infection and the occurrence of type I MPGN in the allograft in renal transplantation, with terminal renal failure as an outcome.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/11.supp4.54</identifier><identifier>PMID: 8918756</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies, Viral - analysis ; Biological and medical sciences ; Biopsy ; Child ; Cryoglobulinemia - epidemiology ; Cryoglobulinemia - etiology ; Cryoglobulinemia - pathology ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Glomerulonephritis, Membranoproliferative - epidemiology ; Glomerulonephritis, Membranoproliferative - etiology ; Glomerulonephritis, Membranoproliferative - pathology ; Hepacivirus - genetics ; Hepacivirus - immunology ; Hepatitis C - complications ; Humans ; Kidney Transplantation ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; Prevalence ; Prognosis ; Recurrence ; Renal Insufficiency - epidemiology ; Renal Insufficiency - etiology ; Retrospective Studies ; RNA, Viral - analysis ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system</subject><ispartof>Nephrology, dialysis, transplantation, 1996, Vol.11 (supp4), p.54-55</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-88c1e6c516b8ddd5beb4fc55cd69444e98b01131710175649a88b5eca349f28e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4009,4035,4036,23910,23911,25119,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3240193$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8918756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAMMOUD, H</creatorcontrib><creatorcontrib>HAEM, J</creatorcontrib><creatorcontrib>LAURENT, B</creatorcontrib><creatorcontrib>ALAMARTINE, E</creatorcontrib><creatorcontrib>DIAB, N</creatorcontrib><creatorcontrib>DEFILIPPIS, J. P</creatorcontrib><creatorcontrib>BERTHOUX, P</creatorcontrib><creatorcontrib>BERTHOUX, F</creatorcontrib><title>Glomerular disease during HCV infection in renal transplantation</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>In general nephrology, HCV infection has been associated with type I membranoproliferative glomerulonephritis (MPGN type I) associated with cryoglobulinaemia. In a cohort of 399 renal transplantation (RT) recipients, 117 of whom (29%) were HCV-positive, we selected all patients diagnosed as having membranous GN or type I MPGN by graft biopsy. The prevalence of MGN was 16/399 (4%) with three recurrences, and 13 de novo cases. Only 5/16 (31%) were HCV+, not different from the general RT population. Five patients had an outcome of graft failure after 43 months. Conversely, there were 15 cases of type I MPGN (two recurrences, 13 de novo) but with eight HCV+ recipients (53%, P = 0.02). Considering only the French patients, prevalence was 44% vs 12% in the French RT population (P = 0.006). Eight patients had graft rejection after 59 months (five HCV+). In this type I MPGN subgroup, there were two positive cryoglobulins, two rheumatoid factors and four hypocomplementaemias. In conclusion, there is a clear association between HCV infection and the occurrence of type I MPGN in the allograft in renal transplantation, with terminal renal failure as an outcome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Child</subject><subject>Cryoglobulinemia - epidemiology</subject><subject>Cryoglobulinemia - etiology</subject><subject>Cryoglobulinemia - pathology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerulonephritis, Membranoproliferative - epidemiology</subject><subject>Glomerulonephritis, Membranoproliferative - etiology</subject><subject>Glomerulonephritis, Membranoproliferative - pathology</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis C - complications</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Renal Insufficiency - epidemiology</subject><subject>Renal Insufficiency - etiology</subject><subject>Retrospective Studies</subject><subject>RNA, Viral - analysis</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAQhi0EKqUwMyFlQGxpfbGd2BuoghapEguwWo59QUH5wk4G_j0urTrdSe9zr04PIbdAl0AVW3VuXAEswzQMfCn4GZkDz2maMSnOyTwSkFJB1SW5CuGbUqqyopiRmVQgC5HPyeOm6Vv0U2N84uqAJmDiJl93X8l2_ZnUXYV2rPsubonHzjTJ6E0XhsZ0o9kH1-SiMk3Am-NckI-X5_f1Nt29bV7XT7vUsjwbUyktYG4F5KV0zokSS15ZIazLFecclSwpAIMCKMTHuDJSlgKtYVxVmUS2IA-H3sH3PxOGUbd1sNjER7Cfgi6k4JkUeQRXB9D6PgSPlR583Rr_q4HqvTMdnWkA_e9MCx4v7o7VU9miO_FHSTG_P-YmWNNUUYCtwwljGaegGPsD5D92KA</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>HAMMOUD, H</creator><creator>HAEM, J</creator><creator>LAURENT, B</creator><creator>ALAMARTINE, E</creator><creator>DIAB, N</creator><creator>DEFILIPPIS, J. P</creator><creator>BERTHOUX, P</creator><creator>BERTHOUX, F</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Glomerular disease during HCV infection in renal transplantation</title><author>HAMMOUD, H ; HAEM, J ; LAURENT, B ; ALAMARTINE, E ; DIAB, N ; DEFILIPPIS, J. P ; BERTHOUX, P ; BERTHOUX, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-88c1e6c516b8ddd5beb4fc55cd69444e98b01131710175649a88b5eca349f28e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Child</topic><topic>Cryoglobulinemia - epidemiology</topic><topic>Cryoglobulinemia - etiology</topic><topic>Cryoglobulinemia - pathology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerulonephritis, Membranoproliferative - epidemiology</topic><topic>Glomerulonephritis, Membranoproliferative - etiology</topic><topic>Glomerulonephritis, Membranoproliferative - pathology</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - immunology</topic><topic>Hepatitis C - complications</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Renal Insufficiency - epidemiology</topic><topic>Renal Insufficiency - etiology</topic><topic>Retrospective Studies</topic><topic>RNA, Viral - analysis</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAMMOUD, H</creatorcontrib><creatorcontrib>HAEM, J</creatorcontrib><creatorcontrib>LAURENT, B</creatorcontrib><creatorcontrib>ALAMARTINE, E</creatorcontrib><creatorcontrib>DIAB, N</creatorcontrib><creatorcontrib>DEFILIPPIS, J. P</creatorcontrib><creatorcontrib>BERTHOUX, P</creatorcontrib><creatorcontrib>BERTHOUX, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAMMOUD, H</au><au>HAEM, J</au><au>LAURENT, B</au><au>ALAMARTINE, E</au><au>DIAB, N</au><au>DEFILIPPIS, J. P</au><au>BERTHOUX, P</au><au>BERTHOUX, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glomerular disease during HCV infection in renal transplantation</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>1996</date><risdate>1996</risdate><volume>11</volume><issue>supp4</issue><spage>54</spage><epage>55</epage><pages>54-55</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>In general nephrology, HCV infection has been associated with type I membranoproliferative glomerulonephritis (MPGN type I) associated with cryoglobulinaemia. In a cohort of 399 renal transplantation (RT) recipients, 117 of whom (29%) were HCV-positive, we selected all patients diagnosed as having membranous GN or type I MPGN by graft biopsy. The prevalence of MGN was 16/399 (4%) with three recurrences, and 13 de novo cases. Only 5/16 (31%) were HCV+, not different from the general RT population. Five patients had an outcome of graft failure after 43 months. Conversely, there were 15 cases of type I MPGN (two recurrences, 13 de novo) but with eight HCV+ recipients (53%, P = 0.02). Considering only the French patients, prevalence was 44% vs 12% in the French RT population (P = 0.006). Eight patients had graft rejection after 59 months (five HCV+). In this type I MPGN subgroup, there were two positive cryoglobulins, two rheumatoid factors and four hypocomplementaemias. In conclusion, there is a clear association between HCV infection and the occurrence of type I MPGN in the allograft in renal transplantation, with terminal renal failure as an outcome.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8918756</pmid><doi>10.1093/ndt/11.supp4.54</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-0509 |
| ispartof | Nephrology, dialysis, transplantation, 1996, Vol.11 (supp4), p.54-55 |
| issn | 0931-0509 1460-2385 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78542856 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antibodies, Viral - analysis Biological and medical sciences Biopsy Child Cryoglobulinemia - epidemiology Cryoglobulinemia - etiology Cryoglobulinemia - pathology Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Glomerulonephritis, Membranoproliferative - epidemiology Glomerulonephritis, Membranoproliferative - etiology Glomerulonephritis, Membranoproliferative - pathology Hepacivirus - genetics Hepacivirus - immunology Hepatitis C - complications Humans Kidney Transplantation Male Medical sciences Middle Aged Polymerase Chain Reaction Prevalence Prognosis Recurrence Renal Insufficiency - epidemiology Renal Insufficiency - etiology Retrospective Studies RNA, Viral - analysis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system |
| title | Glomerular disease during HCV infection in renal transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T06%3A31%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glomerular%20disease%20during%20HCV%20infection%20in%20renal%20transplantation&rft.jtitle=Nephrology,%20dialysis,%20transplantation&rft.au=HAMMOUD,%20H&rft.date=1996&rft.volume=11&rft.issue=supp4&rft.spage=54&rft.epage=55&rft.pages=54-55&rft.issn=0931-0509&rft.eissn=1460-2385&rft.coden=NDTREA&rft_id=info:doi/10.1093/ndt/11.supp4.54&rft_dat=%3Cproquest_cross%3E78542856%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78542856&rft_id=info:pmid/8918756&rfr_iscdi=true |